ID SBK2_HUMAN Reviewed; 348 AA. AC P0C263; DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot. DT 28-JUL-2009, sequence version 2. DT 13-JUN-2012, entry version 48. DE RecName: Full=Serine/threonine-protein kinase SBK2; DE EC=2.7.11.1; DE AltName: Full=SH3-binding domain kinase family member 2; DE AltName: Full=Sugen kinase 69; DE Short=SgK069; GN Name=SBK2; Synonyms=SGK069; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] RP IDENTIFICATION. RX PubMed=12471243; DOI=10.1126/science.1075762; RA Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S.; RT "The protein kinase complement of the human genome."; RL Science 298:1912-1934(2002). RN [3] RP VARIANTS [LARGE SCALE ANALYSIS] LYS-20; GLU-41 AND ASP-102. RX PubMed=17344846; DOI=10.1038/nature05610; RA Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., RA Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., RA O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., RA Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E., RA Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., RA Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., RA Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., RA West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., RA Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., RA DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., RA Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., RA Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.; RT "Patterns of somatic mutation in human cancer genomes."; RL Nature 446:153-158(2007). CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr CC protein kinase family. STKL subfamily. CC -!- SIMILARITY: Contains 1 protein kinase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC008735; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR IPI; IPI00927133; -. DR RefSeq; NP_001094871.2; NM_001101401.2. DR UniGene; Hs.532676; -. DR ProteinModelPortal; P0C263; -. DR SMR; P0C263; 55-332. DR DMDM; 254763329; -. DR PRIDE; P0C263; -. DR Ensembl; ENST00000344158; ENSP00000345044; ENSG00000187550. DR Ensembl; ENST00000413299; ENSP00000389015; ENSG00000187550. DR GeneID; 646643; -. DR KEGG; hsa:646643; -. DR UCSC; uc010ygc.2; human. DR CTD; 646643; -. DR GeneCards; GC19M056041; -. DR HGNC; HGNC:34416; SBK2. DR HPA; HPA030631; -. DR neXtProt; NX_P0C263; -. DR eggNOG; COG0515; -. DR GeneTree; ENSGT00650000093335; -. DR HOGENOM; HOG000063666; -. DR InParanoid; P0C263; -. DR OMA; LEDMMAL; -. DR OrthoDB; EOG4NVZM1; -. DR NextBio; 119153; -. DR Genevestigator; P0C263; -. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. DR InterPro; IPR011009; Kinase-like_dom. DR InterPro; IPR000719; Prot_kinase_cat_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR Pfam; PF00069; Pkinase; 1. DR SUPFAM; SSF56112; Kinase_like; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 3: Inferred from homology; KW ATP-binding; Complete proteome; Kinase; Nucleotide-binding; KW Polymorphism; Reference proteome; Serine/threonine-protein kinase; KW Transferase. FT CHAIN 1 348 Serine/threonine-protein kinase SBK2. FT /FTId=PRO_0000262994. FT DOMAIN 62 330 Protein kinase. FT NP_BIND 68 76 ATP (By similarity). FT ACT_SITE 183 183 Proton acceptor (By similarity). FT BINDING 91 91 ATP (By similarity). FT VARIANT 20 20 E -> K. FT /FTId=VAR_041077. FT VARIANT 41 41 A -> E. FT /FTId=VAR_041078. FT VARIANT 102 102 G -> D. FT /FTId=VAR_041079. SQ SEQUENCE 348 AA; 38088 MW; 2A7E12C4289AC2C7 CRC64; MPGKQSEEGP AEAGASEDSE EEGLGGLTLE ELQQGQEAAR ALEDMMTLSA QTLVRAEVDE LYEEVRPLGQ GCYGRVLLVT HRQKGTPLAL KQLPKPRTSL RGFLYEFCVG LSLGAHSAIV TAYGIGIESA HSYSFLTEPV LHGDLMAFIQ PKVGLPQPAV HRCAAQLASA LEYIHARGLV YRDLKPENVL VCDPACRRFK LTDFGHTRPR GTLLRLAGPP IPYTAPELCA PPPLPEGLPI QPALDAWALG VLLFCLLTGY FPWDRPLAEA DPFYEDFLIW QASGQPRDRP QPWFGLAAAA DALLRGLLDP HPRRRSAVIA IREHLGRPWR QREGEAEAVG AVEEEAGQ //