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Protein

Serine/threonine-protein kinase SBK2

Gene

SBK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911ATPPROSITE-ProRule annotation
Active sitei183 – 1831Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 769ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP0C263.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SBK2 (EC:2.7.11.1)
Alternative name(s):
SH3-binding domain kinase family member 2
Sugen kinase 69
Short name:
SgK069
Gene namesi
Name:SBK2
Synonyms:SGK069
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:34416. SBK2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiSBK2.
DMDMi254763329.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Serine/threonine-protein kinase SBK2PRO_0000262994Add
BLAST

Proteomic databases

PaxDbiP0C263.
PRIDEiP0C263.

Expressioni

Gene expression databases

BgeeiP0C263.

Organism-specific databases

HPAiHPA030631.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000345044.

Structurei

3D structure databases

ProteinModelPortaliP0C263.
SMRiP0C263. Positions 13-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 330269Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1345. Eukaryota.
ENOG41112JR. LUCA.
GeneTreeiENSGT00680000099954.
HOGENOMiHOG000063666.
InParanoidiP0C263.
KOiK08858.
OMAiWRQREGE.
OrthoDBiEOG7SBNPJ.
PhylomeDBiP0C263.
TreeFamiTF326736.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGKQSEEGP AEAGASEDSE EEGLGGLTLE ELQQGQEAAR ALEDMMTLSA
60 70 80 90 100
QTLVRAEVDE LYEEVRPLGQ GCYGRVLLVT HRQKGTPLAL KQLPKPRTSL
110 120 130 140 150
RGFLYEFCVG LSLGAHSAIV TAYGIGIESA HSYSFLTEPV LHGDLMAFIQ
160 170 180 190 200
PKVGLPQPAV HRCAAQLASA LEYIHARGLV YRDLKPENVL VCDPACRRFK
210 220 230 240 250
LTDFGHTRPR GTLLRLAGPP IPYTAPELCA PPPLPEGLPI QPALDAWALG
260 270 280 290 300
VLLFCLLTGY FPWDRPLAEA DPFYEDFLIW QASGQPRDRP QPWFGLAAAA
310 320 330 340
DALLRGLLDP HPRRRSAVIA IREHLGRPWR QREGEAEAVG AVEEEAGQ
Length:348
Mass (Da):38,088
Last modified:July 28, 2009 - v2
Checksum:i2A7E12C4289AC2C7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201E → K.1 Publication
Corresponds to variant rs34316437 [ dbSNP | Ensembl ].
VAR_041077
Natural varianti41 – 411A → E.1 Publication
VAR_041078
Natural varianti102 – 1021G → D.1 Publication
Corresponds to variant rs56158623 [ dbSNP | Ensembl ].
VAR_041079

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008735 Genomic DNA. No translation available.
CCDSiCCDS42631.1.
RefSeqiNP_001094871.2. NM_001101401.2.
XP_006723390.1. XM_006723327.2.
UniGeneiHs.532676.

Genome annotation databases

EnsembliENST00000344158; ENSP00000345044; ENSG00000187550.
ENST00000413299; ENSP00000389015; ENSG00000187550.
GeneIDi646643.
KEGGihsa:646643.
UCSCiuc032ifw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008735 Genomic DNA. No translation available.
CCDSiCCDS42631.1.
RefSeqiNP_001094871.2. NM_001101401.2.
XP_006723390.1. XM_006723327.2.
UniGeneiHs.532676.

3D structure databases

ProteinModelPortaliP0C263.
SMRiP0C263. Positions 13-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000345044.

Polymorphism and mutation databases

BioMutaiSBK2.
DMDMi254763329.

Proteomic databases

PaxDbiP0C263.
PRIDEiP0C263.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344158; ENSP00000345044; ENSG00000187550.
ENST00000413299; ENSP00000389015; ENSG00000187550.
GeneIDi646643.
KEGGihsa:646643.
UCSCiuc032ifw.2. human.

Organism-specific databases

CTDi646643.
GeneCardsiSBK2.
HGNCiHGNC:34416. SBK2.
HPAiHPA030631.
neXtProtiNX_P0C263.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1345. Eukaryota.
ENOG41112JR. LUCA.
GeneTreeiENSGT00680000099954.
HOGENOMiHOG000063666.
InParanoidiP0C263.
KOiK08858.
OMAiWRQREGE.
OrthoDBiEOG7SBNPJ.
PhylomeDBiP0C263.
TreeFamiTF326736.

Enzyme and pathway databases

SignaLinkiP0C263.

Miscellaneous databases

GenomeRNAii646643.
PROiP0C263.

Gene expression databases

BgeeiP0C263.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-20; GLU-41 AND ASP-102.

Entry informationi

Entry nameiSBK2_HUMAN
AccessioniPrimary (citable) accession number: P0C263
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 28, 2009
Last modified: June 8, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.