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Protein

Conotoxin Ep11.1

Gene
N/A
Organism
Conus episcopatus (Bishop's cone)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Ep11.1
OrganismiConus episcopatus (Bishop's cone)
Taxonomic identifieri88764 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1453. Ep11.1 precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000026267720 – 32Sequence analysisAdd BLAST13
ChainiPRO_000026267834 – 72Conotoxin Ep11.1Add BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 53By similarity
Disulfide bondi46 ↔ 58By similarity
Disulfide bondi52 ↔ 63By similarity
Disulfide bondi57 ↔ 70By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiP0C253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I1 superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR013141. Conotoxin-I_CS.
PROSITEiView protein in PROSITE
PS60019. I_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C253-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLCVTFLLI LVILPSVTGE KSSKRTLSGA ALRGDWGMCS GIGQGCGQDS
60 70
NCCGDMCCYG QICAMTFAAC GP
Length:72
Mass (Da):7,431
Last modified:November 28, 2006 - v1
Checksum:i891842A2474F92BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ959109 Genomic DNA. Translation: ADB93079.1.

Similar proteinsi

Entry informationi

Entry nameiCI1B1_CONEP
AccessioniPrimary (citable) accession number: P0C253
Secondary accession number(s): D6C4G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: November 22, 2017
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families