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Protein

Cyclin-O

Gene

Ccno

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking (By similarity). May be involved in apoptosis in lymphoid cells; however, this result requires additional evidences in vivo. May be involved in oocyte meiotic resumption in oocytes.By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-O
Gene namesi
Name:Ccno
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2145534. Ccno.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleoplasm Source: MGI

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002611561 – 352Cyclin-OAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0C242.
PRIDEiP0C242.

PTM databases

PhosphoSitePlusiP0C242.

Expressioni

Tissue specificityi

Present in respiratory cells (at protein level). Expressed in multiciliated tissue in brain and fallopian tube (at protein level) (PubMed:26777464). Highly expressed in oocytes.3 Publications

Developmental stagei

Expressed in ependymal cells of the embryonic brain, but almost absent in the adult brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000042417.
CleanExiMM_CCNO.
ExpressionAtlasiP0C242. baseline and differential.
GenevisibleiP0C242. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040083.

Structurei

3D structure databases

ProteinModelPortaliP0C242.
SMRiP0C242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 68Poly-Ser6

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000060283.
HOVERGENiHBG062171.
InParanoidiP0C242.
KOiK10861.
OMAiLDLQTFR.
OrthoDBiEOG091G0J8R.
PhylomeDBiP0C242.
TreeFamiTF332057.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR028864. Ccno.
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
PANTHERiPTHR10177:SF299. PTHR10177:SF299. 1 hit.
PfamiView protein in Pfam
PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequencei

Sequence statusi: Complete.

P0C242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTPCPASPG SPAAGAGRRD SHQNLRAPVK KSRRPCLRRK KPLRPLNACS
60 70 80 90 100
LPGDSGVCDL FESPSSSSDG ADSPAVSAAR DCSSLLNPAQ PLTALDLQTF
110 120 130 140 150
REYGQSCYDF RKAQENLFHP RESLARQPQV TAESRCKLLS WLLQVHRQFG
160 170 180 190 200
LSFESLCLTV NTLDRFLLTT PVAADCFQLL GVTCLLIACK QVEVHPPRLK
210 220 230 240 250
QLLALCGGAF SRQQLCNLEC IVLHKLHFSL GAPTINFFLE HFTQWRMEAG
260 270 280 290 300
QAEVTEALEA QTLARGVAEL SLTDYAFTTY TPSLMAICCL ALADGLLQHQ
310 320 330 340 350
HEMDLRLGEH PEATLQDCLG KLQTLVSINS SSLPRILPPQ IWERCSLPQS

WQ
Length:352
Mass (Da):38,822
Last modified:November 28, 2006 - v1
Checksum:i001F10138A890719
GO

Sequence cautioni

The sequence AK086507 differs from that shown. Reason: Frameshift at position 107.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK086507 mRNA. No translation available.
CCDSiCCDS36782.1.
RefSeqiNP_001074531.1. NM_001081062.1.
UniGeneiMm.25457.

Genome annotation databases

EnsembliENSMUST00000038404; ENSMUSP00000040083; ENSMUSG00000042417.
GeneIDi218630.
KEGGimmu:218630.
UCSCiuc007rwz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK086507 mRNA. No translation available.
CCDSiCCDS36782.1.
RefSeqiNP_001074531.1. NM_001081062.1.
UniGeneiMm.25457.

3D structure databases

ProteinModelPortaliP0C242.
SMRiP0C242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040083.

PTM databases

PhosphoSitePlusiP0C242.

Proteomic databases

PaxDbiP0C242.
PRIDEiP0C242.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038404; ENSMUSP00000040083; ENSMUSG00000042417.
GeneIDi218630.
KEGGimmu:218630.
UCSCiuc007rwz.1. mouse.

Organism-specific databases

CTDi10309.
MGIiMGI:2145534. Ccno.

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000060283.
HOVERGENiHBG062171.
InParanoidiP0C242.
KOiK10861.
OMAiLDLQTFR.
OrthoDBiEOG091G0J8R.
PhylomeDBiP0C242.
TreeFamiTF332057.

Miscellaneous databases

PROiP0C242.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042417.
CleanExiMM_CCNO.
ExpressionAtlasiP0C242. baseline and differential.
GenevisibleiP0C242. MM.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR028864. Ccno.
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
PANTHERiPTHR10177:SF299. PTHR10177:SF299. 1 hit.
PfamiView protein in Pfam
PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
SUPFAMiSSF47954. SSF47954. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCCNO_MOUSE
AccessioniPrimary (citable) accession number: P0C242
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: March 15, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.