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Protein

Cyclin-O

Gene

Ccno

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking (By similarity). May be involved in apoptosis in lymphoid cells; however, this result requires additional evidences in vivo. May be involved in oocyte meiotic resumption in oocytes.By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-O
Gene namesi
Name:Ccno
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2145534 Ccno

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002611561 – 352Cyclin-OAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0C242
PRIDEiP0C242

PTM databases

PhosphoSitePlusiP0C242

Expressioni

Tissue specificityi

Present in respiratory cells (at protein level). Expressed in multiciliated tissue in brain and fallopian tube (at protein level) (PubMed:26777464). Highly expressed in oocytes.3 Publications

Developmental stagei

Expressed in ependymal cells of the embryonic brain, but almost absent in the adult brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000042417
CleanExiMM_CCNO
ExpressionAtlasiP0C242 baseline and differential
GenevisibleiP0C242 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040083

Structurei

3D structure databases

ProteinModelPortaliP0C242
SMRiP0C242
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 68Poly-Ser6

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00760000118939
HOGENOMiHOG000060283
HOVERGENiHBG062171
InParanoidiP0C242
KOiK10861
OMAiLDLQTFR
OrthoDBiEOG091G0J8R
PhylomeDBiP0C242
TreeFamiTF332057

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR028864 Ccno
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PANTHERiPTHR10177:SF14 PTHR10177:SF14, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

Sequencei

Sequence statusi: Complete.

P0C242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTPCPASPG SPAAGAGRRD SHQNLRAPVK KSRRPCLRRK KPLRPLNACS
60 70 80 90 100
LPGDSGVCDL FESPSSSSDG ADSPAVSAAR DCSSLLNPAQ PLTALDLQTF
110 120 130 140 150
REYGQSCYDF RKAQENLFHP RESLARQPQV TAESRCKLLS WLLQVHRQFG
160 170 180 190 200
LSFESLCLTV NTLDRFLLTT PVAADCFQLL GVTCLLIACK QVEVHPPRLK
210 220 230 240 250
QLLALCGGAF SRQQLCNLEC IVLHKLHFSL GAPTINFFLE HFTQWRMEAG
260 270 280 290 300
QAEVTEALEA QTLARGVAEL SLTDYAFTTY TPSLMAICCL ALADGLLQHQ
310 320 330 340 350
HEMDLRLGEH PEATLQDCLG KLQTLVSINS SSLPRILPPQ IWERCSLPQS

WQ
Length:352
Mass (Da):38,822
Last modified:November 28, 2006 - v1
Checksum:i001F10138A890719
GO

Sequence cautioni

The sequence AK086507 differs from that shown. Reason: Frameshift at position 107.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK086507 mRNA No translation available.
CCDSiCCDS36782.1
RefSeqiNP_001074531.1, NM_001081062.1
UniGeneiMm.25457

Genome annotation databases

EnsembliENSMUST00000038404; ENSMUSP00000040083; ENSMUSG00000042417
GeneIDi218630
KEGGimmu:218630
UCSCiuc007rwz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCCNO_MOUSE
AccessioniPrimary (citable) accession number: P0C242
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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