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Protein

U1-theraphotoxin-Pc1a

Gene
N/A
Organism
Psalmopoeus cambridgei (Trinidad chevron tarantula)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Possess strong antiplasmodial activity against the intra-erythrocyte stage of P.falciparum in vitro. IC50 for inhibiting P.falciparum growth is 1.59 µM. Interacts with infected and healthy erythrocytes. Does not lyse erythrocytes, is not cytotoxic to nucleated mammalian cells, and does not inhibit neuromuscular function. Has neither antibacterial nor antifungal activity.1 Publication

Keywordsi

Molecular functionToxin

Names & Taxonomyi

Protein namesi
Recommended name:
U1-theraphotoxin-Pc1a
Short name:
U1-TRTX-Pc1a
Alternative name(s):
Psalmopeotoxin I
Psalmopeotoxin-1
Psalmopoeus cambridgei Falciparum killer 1
Short name:
PcFK1
OrganismiPsalmopoeus cambridgei (Trinidad chevron tarantula)
Taxonomic identifieri179874 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeTheraphosidaePsalmopoeus

Organism-specific databases

ArachnoServeriAS000318. U1-theraphotoxin-Pc1a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000025669422 – 49Add BLAST28
ChainiPRO_000025669552 – 84U1-theraphotoxin-Pc1aAdd BLAST33

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 701 Publication
Disulfide bondi60 ↔ 751 Publication
Disulfide bondi69 ↔ 801 Publication
Modified residuei84Valine amide1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

186
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi64 – 66Combined sources3
Beta strandi73 – 76Combined sources4
Beta strandi78 – 82Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X5VNMR-A52-84[»]
ProteinModelPortaliP0C201.
SMRiP0C201.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C201.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Keywords - Domaini

Knottin, Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRVLIVTAV FTFFLVLTSS GHDEDNEQRN ILEGMFLDRA IETPKGLEEK
60 70 80
RACGILHDNC VYVPAQNPCC RGLQCRYGKC LVQVGR
Length:86
Mass (Da):9,719
Last modified:October 31, 2006 - v1
Checksum:i9E63221359955A21
GO

Mass spectrometryi

Molecular mass is 3615.60 Da from positions 52 - 84. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X5VNMR-A52-84[»]
ProteinModelPortaliP0C201.
SMRiP0C201.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS000318. U1-theraphotoxin-Pc1a.

Miscellaneous databases

EvolutionaryTraceiP0C201.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiTXFK1_PSACA
AccessioniPrimary (citable) accession number: P0C201
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 2, 2016
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.