P0C1Z6 (TFPT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
TCF3 fusion partner

Alternative name(s):
INO80 complex subunit F
Protein FB1

Gene names

Name:	TFPT
Synonyms:	INO80F

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Appears to promote apoptosis in a p53/TP53-independent manner. Ref.4 Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Ref.4
Subunit structure	Interacts with NOL3 By similarity. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.
Subcellular location	Nucleus Ref.7.
Involvement in disease	Note=A chromosomal aberration involving TFPT is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Inversion inv(19)(p13;q13) with TCF3.

Ontologies

Keywords
Biological process	Apoptosis DNA damage DNA recombination DNA repair Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Chromosomal rearrangement
Disease	Proto-oncogene
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW DNA repair Inferred from electronic annotation. Source: UniProtKB-KW apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW induction of apoptosis Inferred from direct assay Ref.4. Source: UniProtKB regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Ino80 complex Inferred from direct assay Ref.10. Source: UniProtKB cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	DNA binding Inferred from sequence or structural similarity. Source: UniProtKB protein binding Inferred from physical interaction Ref.7. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EAF2	Q96CJ1	4	EBI-1245626,EBI-1245604
UCHL5	Q9Y5K5	3	EBI-1245626,EBI-1051183

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	TCF3 fusion partner		PRO_0000254581
Amino acid modifications
	Modified residue	180	1	Phosphoserine Ref.5 Ref.6 Ref.8 Ref.9
	Modified residue	188	1	Phosphoserine Ref.8
	Modified residue	249	1	Phosphoserine Ref.5 Ref.8
	Modified residue	252	1	Phosphoserine Ref.5 Ref.8 Ref.9

Sequences

	Sequence		Length	Mass (Da)
	P0C1Z6 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: C57CC8436F963F36	FASTA	253	28,278
	10 20 30 40 50 60 MELEQREGTM AAVGFEEFSA PPGSELALPP LFGGHILESE LETEVEFVSG GLGGSGLRER 70 80 90 100 110 120 DEEEEAARGR RRRQRELNRR KYQALGRRCR EIEQVNERVL NRLHQVQRIT RRLQQERRFL 130 140 150 160 170 180 MRVLDSYGDD YRASQFTIVL EDEGSQGTDA PTPGNAENEP PEKETLSPPR RTPAPPEPGS 190 200 210 220 230 240 PAPGEGPSGR KRRRVPRDGR RAGNALTPEL APVQIKVEED FGFEADEALD SSWVSRGPDK 250 LLPYPTLASP ASD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel molecular partner of the E2A gene in childhood leukemia." Brambillasca F., Mosna G., Colombo M., Rivolta A., Caslini C., Minuzzo M., Giudici G., Mizzi L., Biondi A., Privitera E. Leukemia 13:369-375(1999) [PubMed: 10086727] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION WITH TCF3. Tissue: Leukemia.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin and Uterus.
[3]	"A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex." Jin J., Cai Y., Yao T., Gottschalk A.J., Florens L., Swanson S.K., Gutierrez J.L., Coleman M.K., Workman J.L., Mushegian A., Washburn M.P., Conaway R.C., Conaway J.W. J. Biol. Chem. 280:41207-41212(2005) [PubMed: 16230350] [Abstract] Cited for: IDENTIFICATION IN INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[4]	"Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner) appears p53 independent, cell type restricted and cell density influenced." Franchini C., Fontana F., Minuzzo M., Babbio F., Privitera E. Apoptosis 11:2217-2224(2006) [PubMed: 17041757] [Abstract] Cited for: POSSIBLE FUNCTION IN APOPTOSIS.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180; SER-249 AND SER-252, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex." Yao T., Song L., Jin J., Cai Y., Takahashi H., Swanson S.K., Washburn M.P., Florens L., Conaway R.C., Cohen R.E., Conaway J.W. Mol. Cell 31:909-917(2008) [PubMed: 18922472] [Abstract] Cited for: IDENTIFICATION IN THE INO80 COMPLEX, SUBCELLULAR LOCATION, MASS SPECTROMETRY.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180; SER-188; SER-249 AND SER-252, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180 AND SER-252, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[10]	"Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling." Chen L., Cai Y., Jin J., Florens L., Swanson S.K., Washburn M.P., Conaway J.W., Conaway R.C. J. Biol. Chem. 286:11283-11289(2011) [PubMed: 21303910] [Abstract] Cited for: IDENTIFICATION IN THE INO80 COMPLEX.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF052052 mRNA. Translation: AAD45182.1. BC004281 mRNA. Translation: AAH04281.1. BC007776 mRNA. Translation: AAH07776.1.
RefSeq	NP_037474.1. NM_013342.3.
UniGene	Hs.590939.
3D structure databases
ProteinModelPortal	P0C1Z6.
ModBase	Search...
Protein-protein interaction databases
IntAct	P0C1Z6. 11 interactions.
STRING	P0C1Z6.
PTM databases
PhosphoSite	P0C1Z6.
Polymorphism databases
DMDM	126352246.
Proteomic databases
PRIDE	P0C1Z6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339150; ENSP00000344343; ENSG00000105619. ENST00000391759; ENSP00000375639; ENSG00000105619.
GeneID	29844.
KEGG	hsa:29844.
UCSC	uc002qdg.1. human.
Organism-specific databases
CTD	29844.
GeneCards	GC19M054610.
H-InvDB	HIX0015430.
HGNC	HGNC:13630. TFPT.
HPA	HPA034958.
MIM	609519. gene.
neXtProt	NX_P0C1Z6.
PharmGKB	PA37802.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08742.
GeneTree	ENSGT00390000016605.
HOGENOM	HBG283373.
HOVERGEN	HBG056588.
InParanoid	P0C1Z6.
OMA	AGQFTIV.
OrthoDB	EOG48PMMP.
PhylomeDB	P0C1Z6.
Gene expression databases
ArrayExpress	P0C1Z6.
Bgee	P0C1Z6.
CleanEx	HS_TFPT.
Genevestigator	P0C1Z6.
Family and domain databases
KO	K11670.
ProtoNet	Search...
Other
NextBio	52383.
SOURCE	Search...

Entry information

Entry name

TFPT_HUMAN

Accession

Primary (citable) accession number: P0C1Z6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.