Reviewed,
UniProtKB/Swiss-Prot P0C1Z6 (TFPT_HUMAN)
Last modified
November 25, 2008.
Version 21.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: TCF3 fusion partner Alternative name(s): Protein FB1 INO80 complex subunit F | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 253 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subunit structure | Interacts with NOL3 By similarity. Component of the chromatin-remodeling INO80 complex, at least composed of ACTL6A, ACTR5, ACTR8, RVBL1, RVBL2, INO80, INO80B, INO80C, INO80D and INO80E. |
| Subcellular location | NucleusBy similarity. |
| Involvement in disease | A chromosomal aberration involving TFPT is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Inversion inv(19)(p13;q13) with TCF3. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Nucleus |
| Coding sequence diversity | Chromosomal rearrangement |
| Disease | Proto-oncogene |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| EAF1 | Q96JC9 | 1 | EBI-1245626,EBI-769261 | |
| EAF2 | Q96CJ1 | 3 | EBI-1245626,EBI-1245604 | |
| ELL | P55199 | 1 | EBI-1245626,EBI-1245868 |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of a novel molecular partner of the E2A gene in childhood leukemia." Brambillasca F., Mosna G., Colombo M., Rivolta A., Caslini C., Minuzzo M., Giudici G., Mizzi L., Biondi A., Privitera E. Leukemia 13:369-375(1999) [PubMed: 10086727] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION WITH TCF3. Tissue: Leukemia. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin and Uterus. |
| [3] | "A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex." Jin J., Cai Y., Yao T., Gottschalk A.J., Florens L., Swanson S.K., Gutierrez J.L., Coleman M.K., Workman J.L., Mushegian A., Washburn M.P., Conaway R.C., Conaway J.W. J. Biol. Chem. 280:41207-41212(2005) [PubMed: 16230350] [Abstract] Cited for: IDENTIFICATION IN INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY. |
| [4] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180; SER-249 AND SER-252, MASS SPECTROMETRY. Tissue: Epithelium. |
| [5] | "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AF052052 mRNA. Translation: AAD45182.1. BC004281 mRNA. Translation: AAH04281.1. BC007776 mRNA. Translation: AAH07776.1. | |
| RefSeq | NP_037474.1. |
| UniGene | Hs.590939 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P0C1Z6. |
PTM databases | |
| PhosphoSite | P0C1Z6. |
Genome annotation databases | |
| Ensembl | ENSG00000105619. Homo sapiens. [Contig view] |
| GeneID | 29844. |
| KEGG | hsa:29844. |
Organism-specific databases | |
| HGNC | HGNC:13630. TFPT. |
| MIM | 609519. gene. |
| PharmGKB | PA37802. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | P0C1Z6. |
Gene expression databases | |
| ArrayExpress | P0C1Z6. |
| CleanEx | HS_TFPT. |
Family and domain databases | |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 52383. |
| SOURCE | Search... |
Entry information
| Entry name | TFPT_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P0C1Z6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |

Clusters with


