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Protein

TCF3 fusion partner

Gene

TFPT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Appears to promote apoptosis in a p53/TP53-independent manner.
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5689603. UCH proteinases.
R-HSA-5696394. DNA Damage Recognition in GG-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
TCF3 fusion partner
Alternative name(s):
INO80 complex subunit F
Protein FB1
Gene namesi
Name:TFPT
Synonyms:INO80F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13630. TFPT.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • Ino80 complex Source: UniProtKB
  • nuclear membrane Source: HPA
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving TFPT is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Inversion inv(19)(p13;q13) with TCF3.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi29844.
OpenTargetsiENSG00000105619.
ENSG00000273833.
ENSG00000274073.
ENSG00000275086.
ENSG00000276022.
ENSG00000276263.
ENSG00000276296.
ENSG00000276323.
ENSG00000276504.
ENSG00000278161.
PharmGKBiPA37802.

Polymorphism and mutation databases

BioMutaiTFPT.
DMDMi126352246.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002545811 – 253TCF3 fusion partnerAdd BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167PhosphoserineCombined sources1
Modified residuei172PhosphothreonineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Modified residuei207PhosphothreonineCombined sources1
Modified residuei249PhosphoserineCombined sources1
Modified residuei252PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP0C1Z6.
MaxQBiP0C1Z6.
PaxDbiP0C1Z6.
PeptideAtlasiP0C1Z6.
PRIDEiP0C1Z6.

PTM databases

iPTMnetiP0C1Z6.
PhosphoSitePlusiP0C1Z6.

Expressioni

Gene expression databases

BgeeiENSG00000105619.
CleanExiHS_TFPT.
ExpressionAtlasiP0C1Z6. baseline and differential.
GenevisibleiP0C1Z6. HS.

Organism-specific databases

HPAiHPA034958.
HPA058534.

Interactioni

Subunit structurei

Interacts with NOL3; translocates NOL3 into the nucleus and negatively regulated TFPT-induced cell death (By similarity). Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EAF2Q96CJ14EBI-1245626,EBI-1245604
UCHL5Q9Y5K53EBI-1245626,EBI-1051183

Protein-protein interaction databases

BioGridi118931. 42 interactors.
IntActiP0C1Z6. 13 interactors.
STRINGi9606.ENSP00000375639.

Structurei

3D structure databases

ProteinModelPortaliP0C1Z6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IY8E. Eukaryota.
ENOG4111UBX. LUCA.
GeneTreeiENSGT00390000016605.
HOGENOMiHOG000139148.
HOVERGENiHBG056588.
InParanoidiP0C1Z6.
KOiK11670.
OMAiMRVLDAY.
OrthoDBiEOG091G0WHN.
PhylomeDBiP0C1Z6.
TreeFamiTF338152.

Family and domain databases

InterProiIPR033555. TFPT.
[Graphical view]
PANTHERiPTHR35084. PTHR35084. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C1Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELEQREGTM AAVGFEEFSA PPGSELALPP LFGGHILESE LETEVEFVSG
60 70 80 90 100
GLGGSGLRER DEEEEAARGR RRRQRELNRR KYQALGRRCR EIEQVNERVL
110 120 130 140 150
NRLHQVQRIT RRLQQERRFL MRVLDSYGDD YRASQFTIVL EDEGSQGTDA
160 170 180 190 200
PTPGNAENEP PEKETLSPPR RTPAPPEPGS PAPGEGPSGR KRRRVPRDGR
210 220 230 240 250
RAGNALTPEL APVQIKVEED FGFEADEALD SSWVSRGPDK LLPYPTLASP

ASD
Length:253
Mass (Da):28,278
Last modified:October 31, 2006 - v1
Checksum:iC57CC8436F963F36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052052 mRNA. Translation: AAD45182.1.
BC004281 mRNA. Translation: AAH04281.1.
BC007776 mRNA. Translation: AAH07776.1.
CCDSiCCDS12878.1.
RefSeqiNP_037474.1. NM_013342.3.
UniGeneiHs.590939.
Hs.745267.

Genome annotation databases

EnsembliENST00000391759; ENSP00000375639; ENSG00000105619.
ENST00000611514; ENSP00000481443; ENSG00000278161.
ENST00000611935; ENSP00000482185; ENSG00000276022.
ENST00000614788; ENSP00000482785; ENSG00000273833.
ENST00000615534; ENSP00000480353; ENSG00000274073.
ENST00000615620; ENSP00000483971; ENSG00000276263.
ENST00000616277; ENSP00000483417; ENSG00000276296.
ENST00000616798; ENSP00000480169; ENSG00000276504.
ENST00000617348; ENSP00000477775; ENSG00000275086.
ENST00000619581; ENSP00000484685; ENSG00000276323.
GeneIDi29844.
KEGGihsa:29844.
UCSCiuc010yej.1. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052052 mRNA. Translation: AAD45182.1.
BC004281 mRNA. Translation: AAH04281.1.
BC007776 mRNA. Translation: AAH07776.1.
CCDSiCCDS12878.1.
RefSeqiNP_037474.1. NM_013342.3.
UniGeneiHs.590939.
Hs.745267.

3D structure databases

ProteinModelPortaliP0C1Z6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118931. 42 interactors.
IntActiP0C1Z6. 13 interactors.
STRINGi9606.ENSP00000375639.

PTM databases

iPTMnetiP0C1Z6.
PhosphoSitePlusiP0C1Z6.

Polymorphism and mutation databases

BioMutaiTFPT.
DMDMi126352246.

Proteomic databases

EPDiP0C1Z6.
MaxQBiP0C1Z6.
PaxDbiP0C1Z6.
PeptideAtlasiP0C1Z6.
PRIDEiP0C1Z6.

Protocols and materials databases

DNASUi29844.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391759; ENSP00000375639; ENSG00000105619.
ENST00000611514; ENSP00000481443; ENSG00000278161.
ENST00000611935; ENSP00000482185; ENSG00000276022.
ENST00000614788; ENSP00000482785; ENSG00000273833.
ENST00000615534; ENSP00000480353; ENSG00000274073.
ENST00000615620; ENSP00000483971; ENSG00000276263.
ENST00000616277; ENSP00000483417; ENSG00000276296.
ENST00000616798; ENSP00000480169; ENSG00000276504.
ENST00000617348; ENSP00000477775; ENSG00000275086.
ENST00000619581; ENSP00000484685; ENSG00000276323.
GeneIDi29844.
KEGGihsa:29844.
UCSCiuc010yej.1. human.

Organism-specific databases

CTDi29844.
DisGeNETi29844.
GeneCardsiTFPT.
HGNCiHGNC:13630. TFPT.
HPAiHPA034958.
HPA058534.
MIMi609519. gene.
neXtProtiNX_P0C1Z6.
OpenTargetsiENSG00000105619.
ENSG00000273833.
ENSG00000274073.
ENSG00000275086.
ENSG00000276022.
ENSG00000276263.
ENSG00000276296.
ENSG00000276323.
ENSG00000276504.
ENSG00000278161.
PharmGKBiPA37802.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY8E. Eukaryota.
ENOG4111UBX. LUCA.
GeneTreeiENSGT00390000016605.
HOGENOMiHOG000139148.
HOVERGENiHBG056588.
InParanoidiP0C1Z6.
KOiK11670.
OMAiMRVLDAY.
OrthoDBiEOG091G0WHN.
PhylomeDBiP0C1Z6.
TreeFamiTF338152.

Enzyme and pathway databases

ReactomeiR-HSA-5689603. UCH proteinases.
R-HSA-5696394. DNA Damage Recognition in GG-NER.

Miscellaneous databases

ChiTaRSiTFPT. human.
GeneWikiiTFPT.
GenomeRNAii29844.
PROiP0C1Z6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105619.
CleanExiHS_TFPT.
ExpressionAtlasiP0C1Z6. baseline and differential.
GenevisibleiP0C1Z6. HS.

Family and domain databases

InterProiIPR033555. TFPT.
[Graphical view]
PANTHERiPTHR35084. PTHR35084. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTFPT_HUMAN
AccessioniPrimary (citable) accession number: P0C1Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.