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P0C1Z6 (TFPT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
TCF3 fusion partner
Alternative name(s):
INO80 complex subunit F
Protein FB1
Gene names
Name:TFPT
Synonyms:INO80F
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Appears to promote apoptosis in a p53/TP53-independent manner. Ref.4

Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Ref.4

Subunit structure

Interacts with NOL3 By similarity. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.

Subcellular location

Nucleus Ref.7.

Involvement in disease

Note=A chromosomal aberration involving TFPT is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Inversion inv(19)(p13;q13) with TCF3.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 253253TCF3 fusion partner
PRO_0000254581

Amino acid modifications

Modified residue1801Phosphoserine Ref.5 Ref.6 Ref.8 Ref.9
Modified residue1881Phosphoserine Ref.8
Modified residue2491Phosphoserine Ref.5 Ref.8
Modified residue2521Phosphoserine Ref.5 Ref.8 Ref.9

Sequences

Sequence LengthMass (Da)Tools
P0C1Z6 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: C57CC8436F963F36

FASTA25328,278
        10         20         30         40         50         60 
MELEQREGTM AAVGFEEFSA PPGSELALPP LFGGHILESE LETEVEFVSG GLGGSGLRER 

        70         80         90        100        110        120 
DEEEEAARGR RRRQRELNRR KYQALGRRCR EIEQVNERVL NRLHQVQRIT RRLQQERRFL 

       130        140        150        160        170        180 
MRVLDSYGDD YRASQFTIVL EDEGSQGTDA PTPGNAENEP PEKETLSPPR RTPAPPEPGS 

       190        200        210        220        230        240 
PAPGEGPSGR KRRRVPRDGR RAGNALTPEL APVQIKVEED FGFEADEALD SSWVSRGPDK 

       250 
LLPYPTLASP ASD 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel molecular partner of the E2A gene in childhood leukemia."
Brambillasca F., Mosna G., Colombo M., Rivolta A., Caslini C., Minuzzo M., Giudici G., Mizzi L., Biondi A., Privitera E.
Leukemia 13:369-375(1999) [PubMed: 10086727] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION WITH TCF3.
Tissue: Leukemia.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin and Uterus.
[3]"A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex."
Jin J., Cai Y., Yao T., Gottschalk A.J., Florens L., Swanson S.K., Gutierrez J.L., Coleman M.K., Workman J.L., Mushegian A., Washburn M.P., Conaway R.C., Conaway J.W.
J. Biol. Chem. 280:41207-41212(2005) [PubMed: 16230350] [Abstract]
Cited for: IDENTIFICATION IN INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[4]"Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner) appears p53 independent, cell type restricted and cell density influenced."
Franchini C., Fontana F., Minuzzo M., Babbio F., Privitera E.
Apoptosis 11:2217-2224(2006) [PubMed: 17041757] [Abstract]
Cited for: POSSIBLE FUNCTION IN APOPTOSIS.
[5]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180; SER-249 AND SER-252, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[6]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[7]"Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex."
Yao T., Song L., Jin J., Cai Y., Takahashi H., Swanson S.K., Washburn M.P., Florens L., Conaway R.C., Cohen R.E., Conaway J.W.
Mol. Cell 31:909-917(2008) [PubMed: 18922472] [Abstract]
Cited for: IDENTIFICATION IN THE INO80 COMPLEX, SUBCELLULAR LOCATION, MASS SPECTROMETRY.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180; SER-188; SER-249 AND SER-252, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[9]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180 AND SER-252, MASS SPECTROMETRY.
Tissue: Embryonic kidney.
[10]"Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling."
Chen L., Cai Y., Jin J., Florens L., Swanson S.K., Washburn M.P., Conaway J.W., Conaway R.C.
J. Biol. Chem. 286:11283-11289(2011) [PubMed: 21303910] [Abstract]
Cited for: IDENTIFICATION IN THE INO80 COMPLEX.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF052052 mRNA. Translation: AAD45182.1.
BC004281 mRNA. Translation: AAH04281.1.
BC007776 mRNA. Translation: AAH07776.1.
RefSeqNP_037474.1. NM_013342.3.
UniGeneHs.590939.

3D structure databases

ProteinModelPortalP0C1Z6.
ModBaseSearch...

Protein-protein interaction databases

IntActP0C1Z6. 11 interactions.
STRINGP0C1Z6.

PTM databases

PhosphoSiteP0C1Z6.

Polymorphism databases

DMDM126352246.

Proteomic databases

PRIDEP0C1Z6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339150; ENSP00000344343; ENSG00000105619.
ENST00000391759; ENSP00000375639; ENSG00000105619.
GeneID29844.
KEGGhsa:29844.
UCSCuc002qdg.1. human.

Organism-specific databases

CTD29844.
GeneCardsGC19M054610.
H-InvDBHIX0015430.
HGNCHGNC:13630. TFPT.
HPAHPA034958.
MIM609519. gene.
neXtProtNX_P0C1Z6.
PharmGKBPA37802.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG08742.
GeneTreeENSGT00390000016605.
HOGENOMHBG283373.
HOVERGENHBG056588.
InParanoidP0C1Z6.
OMAAGQFTIV.
OrthoDBEOG48PMMP.
PhylomeDBP0C1Z6.

Gene expression databases

ArrayExpressP0C1Z6.
BgeeP0C1Z6.
CleanExHS_TFPT.
GenevestigatorP0C1Z6.

Family and domain databases

KOK11670.
ProtoNetSearch...

Other

NextBio52383.
SOURCESearch...

Entry information

Entry nameTFPT_HUMAN
AccessionPrimary (citable) accession number: P0C1Z6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot