Reviewed, UniProtKB/Swiss-Prot P0C1Z6 (TFPT_HUMAN)

Names and origin

Protein names

Recommended name:
    TCF3 fusion partner
Alternative name(s):
    Protein FB1
    INO80 complex subunit F

Gene names

Name:	TFPT
Synonyms:	INO80F

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts with NOL3 By similarity. Component of the chromatin-remodeling INO80 complex, at least composed of ACTL6A, ACTR5, ACTR8, RVBL1, RVBL2, INO80, INO80B, INO80C, INO80D and INO80E.
Subcellular location	Nucleus By similarity.
Involvement in disease	A chromosomal aberration involving TFPT is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Inversion inv(19)(p13;q13) with TCF3.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Chromosomal rearrangement
Disease	Proto-oncogene
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	induction of apoptosis Traceable author statement. Source: ProtInc
Cellular component	nucleus Traceable author statement. Source: ProtInc
Molecular function	nuclear localization sequence binding Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EAF1	Q96JC9	1	EBI-1245626,EBI-769261
EAF2	Q96CJ1	3	EBI-1245626,EBI-1245604
ELL	P55199	1	EBI-1245626,EBI-1245868

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	TCF3 fusion partner		PRO_0000254581
Amino acid modifications
	Modified residue	180	1	Phosphoserine Ref.4 Ref.5 Ref.6 Ref.7
	Modified residue	188	1	Phosphoserine Ref.6
	Modified residue	249	1	Phosphoserine Ref.4 Ref.6
	Modified residue	252	1	Phosphoserine Ref.4 Ref.6 Ref.7

Sequences

	Sequence		Length	Mass (Da)
	P0C1Z6-1 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: C57CC8436F963F36	FASTA	253	28,278
	10 20 30 40 50 60 MELEQREGTM AAVGFEEFSA PPGSELALPP LFGGHILESE LETEVEFVSG GLGGSGLRER 70 80 90 100 110 120 DEEEEAARGR RRRQRELNRR KYQALGRRCR EIEQVNERVL NRLHQVQRIT RRLQQERRFL 130 140 150 160 170 180 MRVLDSYGDD YRASQFTIVL EDEGSQGTDA PTPGNAENEP PEKETLSPPR RTPAPPEPGS 190 200 210 220 230 240 PAPGEGPSGR KRRRVPRDGR RAGNALTPEL APVQIKVEED FGFEADEALD SSWVSRGPDK 250 LLPYPTLASP ASD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel molecular partner of the E2A gene in childhood leukemia." Brambillasca F., Mosna G., Colombo M., Rivolta A., Caslini C., Minuzzo M., Giudici G., Mizzi L., Biondi A., Privitera E. Leukemia 13:369-375(1999) [PubMed: 10086727] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION WITH TCF3. Tissue: Leukemia.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin and Uterus.
[3]	"A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex." Jin J., Cai Y., Yao T., Gottschalk A.J., Florens L., Swanson S.K., Gutierrez J.L., Coleman M.K., Workman J.L., Mushegian A., Washburn M.P., Conaway R.C., Conaway J.W. J. Biol. Chem. 280:41207-41212(2005) [PubMed: 16230350] [Abstract] Cited for: IDENTIFICATION IN INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180; SER-249 AND SER-252, MASS SPECTROMETRY. Tissue: Epithelium.
[5]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180, MASS SPECTROMETRY.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180; SER-188; SER-249 AND SER-252, MASS SPECTROMETRY.
[7]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180 AND SER-252, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF052052 mRNA. Translation: AAD45182.1. BC004281 mRNA. Translation: AAH04281.1. BC007776 mRNA. Translation: AAH07776.1.
RefSeq	NP_037474.1.
UniGene	Hs.590939
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P0C1Z6. 3 interactions.
STRING	P0C1Z6.
PTM databases
PhosphoSite	P0C1Z6.
Proteomic databases
PRIDE	P0C1Z6.
Genome annotation databases
Ensembl	ENST00000339150; ENSP00000344343; ENSG00000105619; Homo sapiens. [Genome view] ENST00000391759; ENSP00000375639; ENSG00000105619; Homo sapiens. [Genome view]
GeneID	29844.
KEGG	hsa:29844.
UCSC	uc002qdg.1. human.
Organism-specific databases
CTD	29844.
GeneCards	GC19M059302.
HGNC	HGNC:13630. TFPT.
MIM	609519. gene.
PharmGKB	PA37802.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08742.
HOGENOM	HBG283373.
HOVERGEN	P0C1Z6.
InParanoid	P0C1Z6.
OMA	KSQFTIV.
OrthoDB	EOG9TQPWD.
PhylomeDB	P0C1Z6.
Gene expression databases
ArrayExpress	P0C1Z6.
Bgee	P0C1Z6.
CleanEx	HS_TFPT.
Genevestigator	P0C1Z6.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	52383.
SOURCE	Search...

Entry information

Entry name

TFPT_HUMAN

Accession

Primary (citable) accession number: P0C1Z6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	February 9, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.