Potassium channel toxin kappa-KTx 2.2

Functionⁱ

OmTx1 decreases the amplitude of the potassium current of the rat channels Kv1.1/KCNA1 by 17% and Kv1.2/KCNA2 by 12% as well as human Kv1.3/KCNA3 by 24%.1 Publication

OmTx2 decreases the amplitude of the potassium current of the rat channels Kv1.1/KCNA1 by 8% and Kv1.2/KCNA2 by 10% as well as human Kv1.3/KCNA3 by 36%. Also alters glucose-induced insulin release from pancreatic islets.1 Publication

Keywordsⁱ

Molecular function	Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Molecular function

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Potassium channel toxin kappa-KTx 2.21 Publication Alternative name(s): Toxin OmTx21 Publication Cleaved into the following 2 chains: Potassium channel toxin kappa-KTx 2.11 Publication Alternative name(s): Toxin OmTx11 Publication Potassium channel toxin kappa-KTx 2.41 Publication Alternative name(s): Toxin OmTx41 Publication
Organismⁱ	Opisthacanthus madagascariensis (Scorpion)
Taxonomic identifierⁱ	167108 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Iurida › Scorpionoidea › Hemiscorpiidae › Liochelinae › Opisthacanthus

Subcellular locationⁱ

Secreted
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis."
  Chagot B., Pimentel C., Dai L., Pil J., Tytgat J., Nakajima T., Corzo G., Darbon H., Ferrat G.
  Biochem. J. 388:263-271(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: PROTEIN SEQUENCE, FUNCTION (OMTX1 AND OMTX2), SYNTHESIS (OMTX1; OMTX2 AND OMTX4), IDENTIFICATION BY MASS SPECTROMETRY, STRUCTURE BY NMR (OMTX1 AND OMTX2), DISULFIDE BONDS, SUBCELLULAR LOCATION.

GO - Cellular componentⁱ

extracellular region Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
PeptideⁱPRO_0000254058	1 – 27	Potassium channel toxin kappa-KTx 2.21 PublicationAdd BLAST	27
PeptideⁱPRO_0000254059	1 – 26	Potassium channel toxin kappa-KTx 2.11 PublicationAdd BLAST	26
PeptideⁱPRO_0000254060	1 – 24	Potassium channel toxin kappa-KTx 2.41 PublicationAdd BLAST	24

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	3 ↔ 21	1 Publication
Disulfide bondⁱ	7 ↔ 17	1 Publication

Keywords - PTMⁱ

Disulfide bond

Expressionⁱ

Tissue specificityⁱ

Expressed by the venom gland.1 Publication

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	2 – 10	Combined sources		9
Helixⁱ	15 – 22	Combined sources		8

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1WQC	NMR	-	A	1-26	[»]
	1WQD	NMR	-	A	1-27	[»]
ProteinModelPortalⁱ	P0C1Z3.
SMRⁱ	P0C1Z3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P0C1Z3.

EvolutionaryTraceⁱ

P0C1Z3.

Family & Domainsⁱ

Domainⁱ

Has the structural arrangement of two alpha-helices stabilized by two disulfide bonds (CSalpha/alpha 2(S-S)).1 Publication

Sequence similaritiesⁱ

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor kappa-KTx family. Kappa-KTx 2 subfamily.Curated

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P0C1Z3-1 [UniParc]FASTA Add to basket

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        10         20 
DPCYEVCLQQ HGNVKECEEA CKHPVEY

Length:27

Mass (Da):3,152

Last modified:October 31, 2006 - v1

Checksum:ⁱ888A2DA64298BC32

GO

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1WQC	NMR	-	A	1-26	[»]
	1WQD	NMR	-	A	1-27	[»]
ProteinModelPortalⁱ	P0C1Z3.
SMRⁱ	P0C1Z3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P0C1Z3.

EvolutionaryTraceⁱ

P0C1Z3.

Family and domain databases

ProtoNetⁱ	Search...

ProtoNetⁱ

Search...

Entry informationⁱ

Entry nameⁱ	KKX21_OPIMA
Accessionⁱ	P0C1Z3Primary (citable) accession number: P0C1Z3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
	Last sequence update:	October 31, 2006
	Last modified:	January 18, 2017
	This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Animal Toxin Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries
SIMILARITY comments
Index of protein domains and families

UniProtKB - P0C1Z3 (KKX21_OPIMA)

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Functionⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Expressionⁱ

Tissue specificityⁱ

Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

Family & Domainsⁱ

Domainⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Similar proteinsⁱ

Cross-referencesⁱ

3D structure databases

Protocols and materials databases

Miscellaneous databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0C1Z3 (KKX21_OPIMA)

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Potassium channel toxin kappa-KTx 2.2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Protocols and materials databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ