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P0C1Z2

- CISY_MACFA

UniProt

P0C1Z2 - CISY_MACFA

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Protein

Citrate synthase, mitochondrial

Gene
CS, QtrA-16253
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei301 – 3011 By similarity
Active sitei347 – 3471 By similarity
Active sitei402 – 4021 By similarity

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB
  2. cellular carbohydrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.1)
Alternative name(s):
Citrate (Si)-synthase
Gene namesi
Name:CS
ORF Names:QtrA-16253
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727Mitochondrion By similarityAdd
BLAST
Chaini28 – 466439Citrate synthase, mitochondrialPRO_0000235795Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei57 – 571N6-succinyllysine By similarity
Modified residuei76 – 761N6-acetyllysine; alternate By similarity
Modified residuei76 – 761N6-succinyllysine; alternate By similarity
Modified residuei103 – 1031N6-succinyllysine By similarity
Modified residuei193 – 1931N6-succinyllysine By similarity
Modified residuei321 – 3211N6-acetyllysine; alternate By similarity
Modified residuei321 – 3211N6-succinyllysine; alternate By similarity
Modified residuei327 – 3271N6-acetyllysine; alternate By similarity
Modified residuei327 – 3271N6-succinyllysine; alternate By similarity
Modified residuei375 – 3751N6-acetyllysine; alternate By similarity
Modified residuei375 – 3751N6-succinyllysine; alternate By similarity
Modified residuei382 – 3821N6-acetyllysine By similarity
Modified residuei393 – 3931N6-acetyllysine; alternate By similarity
Modified residuei393 – 3931N6-succinyllysine; alternate By similarity
Modified residuei395 – 3951N6,N6,N6-trimethyllysine By similarity
Modified residuei450 – 4501N6-succinyllysine By similarity
Modified residuei459 – 4591N6-acetyllysine; alternate By similarity
Modified residuei459 – 4591N6-succinyllysine; alternate By similarity

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PRIDEiP0C1Z2.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP0C1Z2.
SMRiP0C1Z2. Positions 28-464.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG005336.
KOiK01647.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C1Z2-1 [UniParc]FASTAAdd to Basket

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MALLTAAARL LGTKNASCLV LAARHASASS TNLKDILADL IPKEQARIKT    50
FRQQHGKTVV GQITVDMMYG GMRGMKGLVY ETSVLDPDEG IRFRGFSIPE 100
CQKLLPKAKG GEEPLPEGLF WLLVTGQIPT EEQVSWLSKE WAKRAALPSH 150
VVTMLDNFPT NLHPMSQLSA AVTALNSESN FARAYAEGIS RTKYWELIYE 200
DSMDLIAKLP CIAAKIYRNL YREGSGIGAI DSNLDWSHNF TNMLGYTDSQ 250
FTELMRLYLT IHSDHEGGNV SAHTSHLVGS ALSDPYLSFA AAMNGLAGPL 300
HGLANQEVLV WLTQLQKEVG KDVSDEKLRD YIWNTLNSGR VVPGYGHAVL 350
RKTDPRYTCQ REFALKHLPN DPMFKLVAQL YKIVPNVLLE QGKAKNPWPN 400
VDAHSGVLLQ YYGMTEMNYY TVLFGVSRAL GVLAQLIWSR ALGFPLERPK 450
SMSTEGLMKF VDSKSG 466
Length:466
Mass (Da):51,698
Last modified:October 17, 2006 - v1
Checksum:iEFECCDC06EAC4E00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB174355 mRNA. Translation: BAE91417.1.
RefSeqiNP_001272053.1. NM_001285124.1.
UniGeneiMfa.10768.

Genome annotation databases

GeneIDi101926620.
KEGGimcf:101926620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB174355 mRNA. Translation: BAE91417.1 .
RefSeqi NP_001272053.1. NM_001285124.1.
UniGenei Mfa.10768.

3D structure databases

ProteinModelPortali P0C1Z2.
SMRi P0C1Z2. Positions 28-464.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P0C1Z2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101926620.
KEGGi mcf:101926620.

Organism-specific databases

CTDi 1431.

Phylogenomic databases

HOVERGENi HBG005336.
KOi K01647.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
    International consortium for macaque cDNA sequencing and analysis
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Temporal cortex.

Entry informationi

Entry nameiCISY_MACFA
AccessioniPrimary (citable) accession number: P0C1Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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