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Protein

Leukocyte-associated immunoglobulin-like receptor 1

Gene

Lair1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity).By similarity

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte-associated immunoglobulin-like receptor 1
Short name:
LAIR-1
Short name:
rLAIR1
Alternative name(s):
CD_antigen: CD305
Gene namesi
Name:Lair1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1560048. Lair1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei144 – 16421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 263242Leukocyte-associated immunoglobulin-like receptor 1PRO_0000250684Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 96By similarity
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Modified residuei227 – 2271PhosphotyrosineBy similarity
Modified residuei257 – 2571PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylation at Tyr-227 and Tyr-257 activates it. May be phosphorylated by LCK (By similarity).By similarity
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP0C1X9.
PRIDEiP0C1X9.

Expressioni

Tissue specificityi

Expressed in lymphoid and non-lymphoid organs.1 Publication

Interactioni

Subunit structurei

Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK. Binds with high affinity to extracellular matrix collagens, the interaction is functionally important (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037815.

Structurei

3D structure databases

ProteinModelPortaliP0C1X9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11286Ig-like C2-typeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi225 – 2306ITIM motif 1
Motifi255 – 2606ITIM motif 2

Domaini

ITIM (immunoreceptor tyrosine-based inhibitor motif) motif is a cytoplasmic motif present in 2 copies in the intracellular part of LAIR1. When phosphorylated, ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, leading to down-regulation of cell activation.1 Publication

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J37Q. Eukaryota.
ENOG41119RI. LUCA.
GeneTreeiENSGT00720000108843.
HOGENOMiHOG000015184.
HOVERGENiHBG081887.
InParanoidiP0C1X9.
KOiK06725.
OMAiFTICAEP.
OrthoDBiEOG7BCNCG.
PhylomeDBiP0C1X9.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C1X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLHSVIVLV LVLCLGWKSN TQEESLSDFT ICAEPGPVIP QGNFITIVCS
60 70 80 90 100
TSGEYDTVRL EKEGSTFMEK KTEPHGKQHR FRIGPVNETI TGYYNCIFEK
110 120 130 140 150
NYVWSQRSND LQLKVIKENV TQGLAPGPSM TSDTSWLKTY SIHILTVVSV
160 170 180 190 200
IFLLCLSLFL FCFLSHRQKK QGLPNNKSQH QRSQERLNLA TNGLEKTSDI
210 220 230 240 250
VMDDSLSEDR QTETWTPVAG DLQEVTYAQL DHDSLTQRTV KDVTPQNRVI
260
MAESSTYAAI MRC
Length:263
Mass (Da):29,724
Last modified:October 3, 2006 - v1
Checksum:i7385B80F2A7AA52B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY863023 mRNA. Translation: AAX55651.1.
RefSeqiNP_001025099.1. NM_001029928.1.
XP_008757196.1. XM_008758974.1.
UniGeneiRn.149608.

Genome annotation databases

EnsembliENSRNOT00000036413; ENSRNOP00000037815; ENSRNOG00000027733.
GeneIDi574531.
KEGGirno:574531.
UCSCiRGD:1560048. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY863023 mRNA. Translation: AAX55651.1.
RefSeqiNP_001025099.1. NM_001029928.1.
XP_008757196.1. XM_008758974.1.
UniGeneiRn.149608.

3D structure databases

ProteinModelPortaliP0C1X9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037815.

Proteomic databases

PaxDbiP0C1X9.
PRIDEiP0C1X9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036413; ENSRNOP00000037815; ENSRNOG00000027733.
GeneIDi574531.
KEGGirno:574531.
UCSCiRGD:1560048. rat.

Organism-specific databases

CTDi3903.
RGDi1560048. Lair1.

Phylogenomic databases

eggNOGiENOG410J37Q. Eukaryota.
ENOG41119RI. LUCA.
GeneTreeiENSGT00720000108843.
HOGENOMiHOG000015184.
HOVERGENiHBG081887.
InParanoidiP0C1X9.
KOiK06725.
OMAiFTICAEP.
OrthoDBiEOG7BCNCG.
PhylomeDBiP0C1X9.
TreeFamiTF336644.

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

PROiP0C1X9.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification and characterization of the rat homologue of LAIR-1."
    Lebbink R.J., de Ruiter T., Kaptijn G.J.A., Meyaard L.
    Immunogenetics 57:344-351(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DOMAIN ITIM MOTIF, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAIR1_RAT
AccessioniPrimary (citable) accession number: P0C1X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 8, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.