P0C1X5 (KA182_TITDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Potassium channel toxin alpha-KTx 18.2 Alternative name(s): Toxin TdK2
Organism	Tityus discrepans (Venezuelan scorpion)
Taxonomic identifier	57059 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Tityus

Protein attributes

Sequence length	34 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Reversibly blocks Shaker B potassium channels.
Subcellular location	Secreted Ref.1.
Tissue specificity	Expressed by the venom gland. Ref.1
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 18 subfamily.
Mass spectrometry	Molecular mass is 3451.4 Da from positions 1 - 34. Determined by ESI. Ref.1

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Ion channel impairing toxin Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 34	34	Potassium channel toxin alpha-KTx 18.2		PRO_0000249964
Amino acid modifications
	Disulfide bond	7 ↔ 26		By similarity
	Disulfide bond	12 ↔ 31		By similarity
	Disulfide bond	16 ↔ 33		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C1X5 [UniParc]. Last modified September 19, 2006. Version 1. Checksum: 081F434A016D339E	FASTA	34	3,457
	10 20 30 TGPQTTCQAS TCEAGCKQIG KSMKSCQGDT CECA

References

[1]

"Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins." Batista C.V.F., D'Suze G., Gomez-Lagunas F., Zamudio F.Z., Encarnacion S., Sevcik C., Possani L.D. Proteomics 6:3718-3727(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Venom.

Cross-references

3D structure databases
ProteinModelPortal	P0C1X5.
SMR	P0C1X5. Positions 1-34.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
PROSITE	PS01138. SCORP_SHORT_TOXIN. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KA182_TITDI

Accession

Primary (citable) accession number: P0C1X5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	September 19, 2006
Last modified:	March 6, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program