Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Potassium channel toxin alpha-KTx 18.2

Gene
N/A
Organism
Tityus discrepans (Venezuelan scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Reversibly blocks Shaker B potassium channels.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei17 – 171Penetrates into Kv1.1 and Kv1.3 pores (when K-21 does not penetrate into it)1 Publication
Sitei21 – 211Penetrates into Kv1.1 and Kv1.3 pores (when K-17 does not penetrate into it)1 Publication

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 18.2
Alternative name(s):
Toxin TdK21 Publication
OrganismiTityus discrepans (Venezuelan scorpion)
Taxonomic identifieri57059 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3434Potassium channel toxin alpha-KTx 18.21 PublicationPRO_0000249964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi7 ↔ 26By similarity
Disulfide bondi12 ↔ 31By similarity
Disulfide bondi16 ↔ 33By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

3D structure databases

ProteinModelPortaliP0C1X5.
SMRiP0C1X5. Positions 1-34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).By similarity

Sequence similaritiesi

Sequencei

Sequence statusi: Complete.

P0C1X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
TGPQTTCQAS TCEAGCKQIG KSMKSCQGDT CECA
Length:34
Mass (Da):3,457
Last modified:September 19, 2006 - v1
Checksum:i081F434A016D339E
GO

Mass spectrometryi

Molecular mass is 3451.4 Da from positions 1 - 34. Determined by ESI. 1 Publication

Cross-referencesi

3D structure databases

ProteinModelPortaliP0C1X5.
SMRiP0C1X5. Positions 1-34.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins."
    Batista C.V.F., D'Suze G., Gomez-Lagunas F., Zamudio F.Z., Encarnacion S., Sevcik C., Possani L.D.
    Proteomics 6:3718-3727(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY, SUBCELLULAR LOCATION, FUNCTION.
    Tissue: Venom.
  2. "Looking over toxin-K(+) channel interactions. Clues from the structural and functional characterization of alpha-KTx toxin Tc32, a Kv1.3 channel blocker."
    Stehling E.G., Sforca M.L., Zanchin N.I., Oyama S. Jr., Pignatelli A., Belluzzi O., Polverini E., Corsini R., Spisni A., Pertinhez T.A.
    Biochemistry 51:1885-1894(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiKA182_TITDI
AccessioniPrimary (citable) accession number: P0C1X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: June 24, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Caution

Lacks the dyad motif characteristic of alpha-KTx and generally associated with channel blockage.Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.