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P0C1X5

- KA182_TITDI

UniProt

P0C1X5 - KA182_TITDI

Protein

Potassium channel toxin alpha-KTx 18.2

Gene
N/A
Organism
Tityus discrepans (Venezuelan scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Reversibly blocks Shaker B potassium channels.

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin alpha-KTx 18.2
    Alternative name(s):
    Toxin TdK2
    OrganismiTityus discrepans (Venezuelan scorpion)
    Taxonomic identifieri57059 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 3434Potassium channel toxin alpha-KTx 18.2PRO_0000249964Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi7 ↔ 26By similarity
    Disulfide bondi12 ↔ 31By similarity
    Disulfide bondi16 ↔ 33By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP0C1X5.
    SMRiP0C1X5. Positions 1-34.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Sequencei

    Sequence statusi: Complete.

    P0C1X5-1 [UniParc]FASTAAdd to Basket

    « Hide

    TGPQTTCQAS TCEAGCKQIG KSMKSCQGDT CECA                    34
    Length:34
    Mass (Da):3,457
    Last modified:September 19, 2006 - v1
    Checksum:i081F434A016D339E
    GO

    Mass spectrometryi

    Molecular mass is 3451.4 Da from positions 1 - 34. Determined by ESI. 1 Publication

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P0C1X5.
    SMRi P0C1X5. Positions 1-34.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins."
      Batista C.V.F., D'Suze G., Gomez-Lagunas F., Zamudio F.Z., Encarnacion S., Sevcik C., Possani L.D.
      Proteomics 6:3718-3727(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Venom.

    Entry informationi

    Entry nameiKA182_TITDI
    AccessioniPrimary (citable) accession number: P0C1X5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: September 19, 2006
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3