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Protein

Potassium channel toxin alpha-KTx 18.2

Gene
N/A
Organism
Tityus discrepans (Venezuelan scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Reversibly blocks Shaker B potassium channels.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei17Penetrates into Kv1.1 and Kv1.3 pores (when K-21 does not penetrate into it)1 Publication1
Sitei21Penetrates into Kv1.1 and Kv1.3 pores (when K-17 does not penetrate into it)1 Publication1

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 18.2
Alternative name(s):
Toxin TdK21 Publication
OrganismiTityus discrepans (Venezuelan scorpion)
Taxonomic identifieri57059 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00002499641 – 34Potassium channel toxin alpha-KTx 18.21 PublicationAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 26By similarity
Disulfide bondi12 ↔ 31By similarity
Disulfide bondi16 ↔ 33By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

3D structure databases

ProteinModelPortaliP0C1X5.
SMRiP0C1X5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).By similarity

Sequence similaritiesi

Sequencei

Sequence statusi: Complete.

P0C1X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
TGPQTTCQAS TCEAGCKQIG KSMKSCQGDT CECA
Length:34
Mass (Da):3,457
Last modified:September 19, 2006 - v1
Checksum:i081F434A016D339E
GO

Mass spectrometryi

Molecular mass is 3451.4 Da from positions 1 - 34. Determined by ESI. 1 Publication

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKA182_TITDI
AccessioniPrimary (citable) accession number: P0C1X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: May 10, 2017
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Caution

Lacks the dyad motif characteristic of alpha-KTx and generally associated with channel blockage.Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families