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P0C1X5 (KA182_TITDI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 18.2
Alternative name(s):
Toxin TdK2
OrganismTityus discrepans (Venezuelan scorpion)
Taxonomic identifier57059 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Protein attributes

Sequence length34 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Reversibly blocks Shaker B potassium channels.

Subcellular location

Secreted Ref.1.

Tissue specificity

Expressed by the venom gland. Ref.1

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 18 subfamily.

Mass spectrometry

Molecular mass is 3451.4 Da from positions 1 - 34. Determined by ESI. Ref.1

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionIon channel impairing toxin
Neurotoxin
Potassium channel impairing toxin
Toxin
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3434Potassium channel toxin alpha-KTx 18.2
PRO_0000249964

Amino acid modifications

Disulfide bond7 ↔ 26 By similarity
Disulfide bond12 ↔ 31 By similarity
Disulfide bond16 ↔ 33 By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C1X5 [UniParc].

Last modified September 19, 2006. Version 1.
Checksum: 081F434A016D339E

FASTA343,457
        10         20         30 
TGPQTTCQAS TCEAGCKQIG KSMKSCQGDT CECA 

« Hide

References

[1]"Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins."
Batista C.V.F., D'Suze G., Gomez-Lagunas F., Zamudio F.Z., Encarnacion S., Sevcik C., Possani L.D.
Proteomics 6:3718-3727(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Venom.

Cross-references

3D structure databases

ProteinModelPortalP0C1X5.
SMRP0C1X5. Positions 1-34.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameKA182_TITDI
AccessionPrimary (citable) accession number: P0C1X5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: February 19, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries