Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0C1X5

- KA182_TITDI

UniProt

P0C1X5 - KA182_TITDI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Potassium channel toxin alpha-KTx 18.2

Gene
N/A
Organism
Tityus discrepans (Venezuelan scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Reversibly blocks Shaker B potassium channels.

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 18.2
Alternative name(s):
Toxin TdK2
OrganismiTityus discrepans (Venezuelan scorpion)
Taxonomic identifieri57059 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3434Potassium channel toxin alpha-KTx 18.2PRO_0000249964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi7 ↔ 26By similarity
Disulfide bondi12 ↔ 31By similarity
Disulfide bondi16 ↔ 33By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP0C1X5.
SMRiP0C1X5. Positions 1-34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Sequencei

Sequence statusi: Complete.

P0C1X5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30 
TGPQTTCQAS TCEAGCKQIG KSMKSCQGDT CECA
Length:34
Mass (Da):3,457
Last modified:September 19, 2006 - v1
Checksum:i081F434A016D339E
GO

Mass spectrometryi

Molecular mass is 3451.4 Da from positions 1 - 34. Determined by ESI. 1 Publication

Cross-referencesi

3D structure databases

ProteinModelPortali P0C1X5.
SMRi P0C1X5. Positions 1-34.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins."
    Batista C.V.F., D'Suze G., Gomez-Lagunas F., Zamudio F.Z., Encarnacion S., Sevcik C., Possani L.D.
    Proteomics 6:3718-3727(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Venom.

Entry informationi

Entry nameiKA182_TITDI
AccessioniPrimary (citable) accession number: P0C1X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: October 29, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3