Reviewed, UniProtKB/Swiss-Prot P0C1V5 (VHUU_METMP)

Names and origin

Protein names

Recommended name:
    F420-non-reducing hydrogenase vhu subunit U
    EC=1.12.99.-

Gene names

Name:	vhuU
Ordered Locus Names:	MMP1693

Organism

Methanococcus maripaludis [Complete proteome] [HAMAP]

Taxonomic identifier

39152 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	44 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Cofactor	Nickel Potential.
Subunit structure	The F420-non-reducing hydrogenase vhu is composed of four subunits; vhuA, vhuD, vhuG and vhuU By similarity.
Miscellaneous	The large subunit of vhu is split into vhuA and vhuU. Each contributes two ligands to the [NiFeSe] center.
Sequence similarities	Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

Ontologies

Keywords
Coding sequence diversity	Selenocysteine
Ligand	Metal-binding Nickel Selenium
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nickel ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW selenium binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 25	25	F420-non-reducing hydrogenase vhu subunit U		PRO_0000249592
	Propeptide	26 – 44	19	Removed in mature form By similarity		PRO_0000249593
Sites
	Metal binding	20	1	Nickel Potential
	Metal binding	23	1	Nickel Potential
Amino acid modifications
	Non-standard residue	20	1	Selenocysteine Probable

Sequences

	Sequence		Length	Mass (Da)
	P0C1V5-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: DC05EDF4147317EE	FASTA	44	5,083
	10 20 30 40 MVDEAKLNLI EIVLRAYDPU YSCAAHMIVK DEQGKVLLEV KKEE

References

[1]

"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis." Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A. J. Bacteriol. 186:6956-6969(2004) [PubMed: 15466049] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S2 / LL.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX950229 Genomic DNA. Translation: CAF31249.1.
RefSeq	NP_988813.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2762376.
GenomeReviews	Gene locus MMP1693 in contig BX950229_GR.
KEGG	mmp:MMP1693.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P0C1V5.
Family and domain databases
InterPro	IPR018194. Ni-dep_hyd_lsu_Ni_BS. [Graphical view]
PROSITE	PS00508. NI_HGENASE_L_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VHUU_METMP

Accession

Primary (citable) accession number: P0C1V5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	February 26, 2008
Last modified:	March 3, 2009
This is version 16 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)