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Protein

N-acetylmuramoyl-L-alanine amidase sle1

Gene

sle1

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Peptidoglycan hydrolase involved in the splitting of the septum during cell division. Binds to both alpha and beta-chains of human fibrinogen as well as fibronectin, which suggests a role in the colonization of host factor-coated material or host tissue. Also exhibits lytic activity against S.carnosus and S.aureus cells but not against M.luteus cells.1 Publication

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Hydrolase
Biological processCell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
Gene namesi
Name:sle1
Synonyms:aaa
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000023162026 – 334N-acetylmuramoyl-L-alanine amidase sle1Add BLAST309

Structurei

3D structure databases

ProteinModelPortaliP0C1U7.
SMRiP0C1U7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 70LysM 1PROSITE-ProRule annotationAdd BLAST44
Domaini91 – 134LysM 2PROSITE-ProRule annotationAdd BLAST44
Domaini158 – 201LysM 3PROSITE-ProRule annotationAdd BLAST44
Domaini210 – 334Peptidase C51PROSITE-ProRule annotationAdd BLAST125

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG41068JE. Bacteria.
COG1388. LUCA.
COG3942. LUCA.

Family and domain databases

CDDicd00118. LysM. 3 hits.
InterProiView protein in InterPro
IPR007921. CHAP_dom.
IPR018392. LysM_dom.
PfamiView protein in Pfam
PF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
SMARTiView protein in SMART
SM00257. LysM. 3 hits.
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiView protein in PROSITE
PS50911. CHAP. 1 hit.
PS51782. LYSM. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C1U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKKVIAAII GTSAISAVAA TQANAATTHT VKPGESVWAI SNKYGISIAK
60 70 80 90 100
LKSLNNLTSN LIFPNQVLKV SGSSNSTSNS SRPSTNSGGG SYYTVQAGDS
110 120 130 140 150
LSLIASKYGT TYQNIMRLNG LNNFFIYPGQ KLKVSGTASS SNAASNSSRP
160 170 180 190 200
STNSGGGSYY TVQAGDSLSL IASKYGTTYQ KIMSLNGLNN FFIYPGQKLK
210 220 230 240 250
VTGNASTNSG SATTTNRGYN TPVFSHQNLY TWGQCTYHVF NRRAEIGKGI
260 270 280 290 300
STYWWNANNW DNAAAADGYT IDNRPTVGSI AQTDVGYYGH VMFVERVNND
310 320 330
GSILVSEMNY SAAPGILTYR TVPAYQVNNY RYIH
Length:334
Mass (Da):35,836
Last modified:September 5, 2006 - v1
Checksum:i4C1E30AD9DE61D36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250906 Genomic DNA. Translation: CAC80837.1.
RefSeqiWP_001170264.1. NZ_NARB01000001.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSLE1_STAAU
AccessioniPrimary (citable) accession number: P0C1U7
Secondary accession number(s): Q33E91, Q99WD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: July 5, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program