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P0C1U7 (SLE1_STAAU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-acetylmuramoyl-L-alanine amidase sle1

EC=3.5.1.28
Gene names
Name:sle1
Synonyms:aaa
OrganismStaphylococcus aureus
Taxonomic identifier1280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existencePredicted

General annotation (Comments)

Function

Peptidoglycan hydrolase involved in the splitting of the septum during cell division. Binds to both alpha and beta-chains of human fibrinogen as well as fibronectin, which suggests a role in the colonization of host factor-coated material or host tissue. Also exhibits lytic activity against S.carnosus and S.aureus cells but not against M.luteus cells. Ref.1

Catalytic activity

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Subcellular location

Secreted. Cell surface Ref.1.

Sequence similarities

Contains 3 LysM repeats.

Contains 1 peptidase C51 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 334309N-acetylmuramoyl-L-alanine amidase sle1
PRO_0000231620

Regions

Repeat29 – 7143LysM 1
Repeat93 – 13543LysM 2
Repeat160 – 20243LysM 3
Domain210 – 334125Peptidase C51

Sequences

Sequence LengthMass (Da)Tools
P0C1U7 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 4C1E30AD9DE61D36

FASTA33435,836
        10         20         30         40         50         60 
MQKKVIAAII GTSAISAVAA TQANAATTHT VKPGESVWAI SNKYGISIAK LKSLNNLTSN 

        70         80         90        100        110        120 
LIFPNQVLKV SGSSNSTSNS SRPSTNSGGG SYYTVQAGDS LSLIASKYGT TYQNIMRLNG 

       130        140        150        160        170        180 
LNNFFIYPGQ KLKVSGTASS SNAASNSSRP STNSGGGSYY TVQAGDSLSL IASKYGTTYQ 

       190        200        210        220        230        240 
KIMSLNGLNN FFIYPGQKLK VTGNASTNSG SATTTNRGYN TPVFSHQNLY TWGQCTYHVF 

       250        260        270        280        290        300 
NRRAEIGKGI STYWWNANNW DNAAAADGYT IDNRPTVGSI AQTDVGYYGH VMFVERVNND 

       310        320        330 
GSILVSEMNY SAAPGILTYR TVPAYQVNNY RYIH 

« Hide

References

[1]"The multifunctional Staphylococcus aureus autolysin aaa mediates adherence to immobilized fibrinogen and fibronectin."
Heilmann C., Hartleib J., Hussain M.S., Peters G.
Infect. Immun. 73:4793-4802(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
Strain: 4074.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ250906 Genomic DNA. Translation: CAC80837.1.

3D structure databases

ProteinModelPortalP0C1U7.
SMRP0C1U7. Positions 26-207, 228-334.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.10.350.10. 3 hits.
InterProIPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view]
PfamPF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTSM00257. LysM. 3 hits.
[Graphical view]
SUPFAMSSF54106. SSF54106. 3 hits.
PROSITEPS50911. CHAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSLE1_STAAU
AccessionPrimary (citable) accession number: P0C1U7
Secondary accession number(s): Q33E91, Q99WD8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: April 16, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries