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P0C1U7

- SLE1_STAAU

UniProt

P0C1U7 - SLE1_STAAU

Protein

N-acetylmuramoyl-L-alanine amidase sle1

Gene

sle1

Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Peptidoglycan hydrolase involved in the splitting of the septum during cell division. Binds to both alpha and beta-chains of human fibrinogen as well as fibronectin, which suggests a role in the colonization of host factor-coated material or host tissue. Also exhibits lytic activity against S.carnosus and S.aureus cells but not against M.luteus cells.1 Publication

    Catalytic activityi

    Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

    GO - Molecular functioni

    1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. barrier septum assembly Source: UniProtKB-KW
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW
    4. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Hydrolase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
    Gene namesi
    Name:sle1
    Synonyms:aaa
    OrganismiStaphylococcus aureus
    Taxonomic identifieri1280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

    Subcellular locationi

    Secreted 1 Publication. Cell surface 1 Publication

    GO - Cellular componenti

    1. cell surface Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 334309N-acetylmuramoyl-L-alanine amidase sle1PRO_0000231620Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0C1U7.
    SMRiP0C1U7. Positions 228-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati29 – 7143LysM 1Add
    BLAST
    Repeati93 – 13543LysM 2Add
    BLAST
    Repeati160 – 20243LysM 3Add
    BLAST
    Domaini210 – 334125Peptidase C51PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 LysM repeats.Curated
    Contains 1 peptidase C51 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di3.10.350.10. 3 hits.
    InterProiIPR007921. CHAP_dom.
    IPR018392. LysM_dom.
    [Graphical view]
    PfamiPF05257. CHAP. 1 hit.
    PF01476. LysM. 3 hits.
    [Graphical view]
    SMARTiSM00257. LysM. 3 hits.
    [Graphical view]
    SUPFAMiSSF54106. SSF54106. 3 hits.
    PROSITEiPS50911. CHAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C1U7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKKVIAAII GTSAISAVAA TQANAATTHT VKPGESVWAI SNKYGISIAK    50
    LKSLNNLTSN LIFPNQVLKV SGSSNSTSNS SRPSTNSGGG SYYTVQAGDS 100
    LSLIASKYGT TYQNIMRLNG LNNFFIYPGQ KLKVSGTASS SNAASNSSRP 150
    STNSGGGSYY TVQAGDSLSL IASKYGTTYQ KIMSLNGLNN FFIYPGQKLK 200
    VTGNASTNSG SATTTNRGYN TPVFSHQNLY TWGQCTYHVF NRRAEIGKGI 250
    STYWWNANNW DNAAAADGYT IDNRPTVGSI AQTDVGYYGH VMFVERVNND 300
    GSILVSEMNY SAAPGILTYR TVPAYQVNNY RYIH 334
    Length:334
    Mass (Da):35,836
    Last modified:September 5, 2006 - v1
    Checksum:i4C1E30AD9DE61D36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250906 Genomic DNA. Translation: CAC80837.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250906 Genomic DNA. Translation: CAC80837.1 .

    3D structure databases

    ProteinModelPortali P0C1U7.
    SMRi P0C1U7. Positions 228-334.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.10.350.10. 3 hits.
    InterProi IPR007921. CHAP_dom.
    IPR018392. LysM_dom.
    [Graphical view ]
    Pfami PF05257. CHAP. 1 hit.
    PF01476. LysM. 3 hits.
    [Graphical view ]
    SMARTi SM00257. LysM. 3 hits.
    [Graphical view ]
    SUPFAMi SSF54106. SSF54106. 3 hits.
    PROSITEi PS50911. CHAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The multifunctional Staphylococcus aureus autolysin aaa mediates adherence to immobilized fibrinogen and fibronectin."
      Heilmann C., Hartleib J., Hussain M.S., Peters G.
      Infect. Immun. 73:4793-4802(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
      Strain: 4074.

    Entry informationi

    Entry nameiSLE1_STAAU
    AccessioniPrimary (citable) accession number: P0C1U7
    Secondary accession number(s): Q33E91, Q99WD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3