P0C1T1 (HXB2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-B2

Alternative name(s):
Homeobox protein Hox-2.8

Gene names

Name:	Hoxb2
Synonyms:	Hox-2.8

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subunit structure	Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2 By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Proboscipedia subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from mutant phenotype PubMed 9012503. Source: MGI dorsal/ventral pattern formation Inferred from genetic interaction PubMed 10230789. Source: MGI embryonic skeletal system morphogenesis Inferred from genetic interaction PubMed 10885747. Source: MGI facial nerve structural organization Inferred from mutant phenotype PubMed 9012503. Source: MGI morphogenesis of an epithelial sheet Inferred from genetic interaction PubMed 11518511. Source: MGI neural nucleus development Inferred from mutant phenotype PubMed 9012503. Source: MGI rhombomere 3 development Inferred from genetic interaction PubMed 10230789. Source: MGI rhombomere 4 development Inferred from genetic interaction PubMed 10230789. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Homeobox protein Hox-B2		PRO_0000248841
Regions
	DNA binding	141 – 200	60	Homeobox
	Motif	92 – 97	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	P0C1T1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: BA5EB460770DA045	FASTA	354	38,096
	10 20 30 40 50 60 MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPLE QTFPSLQLGA 70 80 90 100 110 120 STLQRPGSQK QAGDGPALRS PPPLPVAPPA PEFPWMKEKK STKKPSQSAA SPSPAASSVR 130 140 150 160 170 180 ASEVGSPSDG PGLPECGGSG SRRLRTAYTN TQLLELEKEF HFNKYLCRPR RVEIAALLDL 190 200 210 220 230 240 TERQVKVWFQ NRRMKHKRQT QHREPPEGEP GGPSAQDDAG EPAEEPTVSP GDVATHRLRE 250 260 270 280 290 300 ACFHPAEAAQ GPRGAPPSAL PATTLESVGA SSPGCTMLRA GGRQSEPLPE DACPERQDSP 310 320 330 340 350 FLPDLNFFAA DSCLQMSGGL SPSLQGSLDS PVPFSEEELD FFTSTLCAID LQFP

References

[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL606824 Genomic DNA. Translation: CAM27581.1. BC138494 mRNA. Translation: AAI38495.1. BC138495 mRNA. Translation: AAI38496.1.
IPI	IPI00124385.
RefSeq	NP_598793.2. NM_134032.2.
UniGene	Mm.281153.
3D structure databases
ProteinModelPortal	P0C1T1.
SMR	P0C1T1. Positions 143-199.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000098092.
PTM databases
PhosphoSite	P0C1T1.
Proteomic databases
PRIDE	P0C1T1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000100523; ENSMUSP00000098092; ENSMUSG00000075588.
GeneID	103889.
KEGG	mmu:103889.
UCSC	uc007lby.1. mouse.
Organism-specific databases
CTD	3212.
MGI	MGI:96183. Hoxb2.
Phylogenomic databases
eggNOG	NOG295272.
GeneTree	ENSGT00700000104446.
HOGENOM	HOG000063664.
HOVERGEN	HBG006088.
InParanoid	P0C1T1.
KO	K09302.
OMA	RAAWEAC.
OrthoDB	EOG4QC167.
Gene expression databases
Bgee	P0C1T1.
CleanEx	MM_HOXB2.
Genevestigator	P0C1T1.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	356175.
SOURCE	Search...

Entry information

Entry name

HXB2_MOUSE

Accession

Primary (citable) accession number: P0C1T1
Secondary accession number(s): A2A739, B9EHW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program