Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0C1T1

- HXB2_MOUSE

UniProt

P0C1T1 - HXB2_MOUSE

Protein

Homeobox protein Hox-B2

Gene

Hoxb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi141 – 20060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. dorsal/ventral pattern formation Source: MGI
    3. embryonic skeletal system morphogenesis Source: MGI
    4. facial nerve structural organization Source: MGI
    5. morphogenesis of an epithelial sheet Source: MGI
    6. neural nucleus development Source: MGI
    7. rhombomere 3 development Source: MGI
    8. rhombomere 4 development Source: MGI
    9. skeletal system morphogenesis Source: MGI
    10. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B2
    Alternative name(s):
    Homeobox protein Hox-2.8
    Gene namesi
    Name:Hoxb2
    Synonyms:Hox-2.8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96183. Hoxb2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354Homeobox protein Hox-B2PRO_0000248841Add
    BLAST

    Proteomic databases

    PRIDEiP0C1T1.

    PTM databases

    PhosphoSiteiP0C1T1.

    Expressioni

    Gene expression databases

    BgeeiP0C1T1.
    CleanExiMM_HOXB2.
    GenevestigatoriP0C1T1.

    Interactioni

    Subunit structurei

    Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000098092.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C1T1.
    SMRiP0C1T1. Positions 143-199.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi92 – 976Antp-type hexapeptide

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG295272.
    GeneTreeiENSGT00750000117389.
    HOGENOMiHOG000063664.
    HOVERGENiHBG006088.
    InParanoidiP0C1T1.
    KOiK09302.
    OMAiLEDICDP.
    OrthoDBiEOG73RBBF.
    PhylomeDBiP0C1T1.
    TreeFamiTF317730.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C1T1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPLE    50
    QTFPSLQLGA STLQRPGSQK QAGDGPALRS PPPLPVAPPA PEFPWMKEKK 100
    STKKPSQSAA SPSPAASSVR ASEVGSPSDG PGLPECGGSG SRRLRTAYTN 150
    TQLLELEKEF HFNKYLCRPR RVEIAALLDL TERQVKVWFQ NRRMKHKRQT 200
    QHREPPEGEP GGPSAQDDAG EPAEEPTVSP GDVATHRLRE ACFHPAEAAQ 250
    GPRGAPPSAL PATTLESVGA SSPGCTMLRA GGRQSEPLPE DACPERQDSP 300
    FLPDLNFFAA DSCLQMSGGL SPSLQGSLDS PVPFSEEELD FFTSTLCAID 350
    LQFP 354
    Length:354
    Mass (Da):38,096
    Last modified:September 5, 2006 - v1
    Checksum:iBA5EB460770DA045
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL606824 Genomic DNA. Translation: CAM27581.1.
    BC138494 mRNA. Translation: AAI38495.1.
    BC138495 mRNA. Translation: AAI38496.1.
    CCDSiCCDS36290.1.
    RefSeqiNP_598793.2. NM_134032.2.
    UniGeneiMm.281153.

    Genome annotation databases

    EnsembliENSMUST00000100523; ENSMUSP00000098092; ENSMUSG00000075588.
    GeneIDi103889.
    KEGGimmu:103889.
    UCSCiuc007lby.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL606824 Genomic DNA. Translation: CAM27581.1 .
    BC138494 mRNA. Translation: AAI38495.1 .
    BC138495 mRNA. Translation: AAI38496.1 .
    CCDSi CCDS36290.1.
    RefSeqi NP_598793.2. NM_134032.2.
    UniGenei Mm.281153.

    3D structure databases

    ProteinModelPortali P0C1T1.
    SMRi P0C1T1. Positions 143-199.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000098092.

    PTM databases

    PhosphoSitei P0C1T1.

    Proteomic databases

    PRIDEi P0C1T1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000100523 ; ENSMUSP00000098092 ; ENSMUSG00000075588 .
    GeneIDi 103889.
    KEGGi mmu:103889.
    UCSCi uc007lby.1. mouse.

    Organism-specific databases

    CTDi 3212.
    MGIi MGI:96183. Hoxb2.

    Phylogenomic databases

    eggNOGi NOG295272.
    GeneTreei ENSGT00750000117389.
    HOGENOMi HOG000063664.
    HOVERGENi HBG006088.
    InParanoidi P0C1T1.
    KOi K09302.
    OMAi LEDICDP.
    OrthoDBi EOG73RBBF.
    PhylomeDBi P0C1T1.
    TreeFami TF317730.

    Miscellaneous databases

    NextBioi 356175.
    PROi P0C1T1.
    SOURCEi Search...

    Gene expression databases

    Bgeei P0C1T1.
    CleanExi MM_HOXB2.
    Genevestigatori P0C1T1.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiHXB2_MOUSE
    AccessioniPrimary (citable) accession number: P0C1T1
    Secondary accession number(s): A2A739, B9EHW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3