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P0C1T1 (HXB2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B2
Alternative name(s):
Homeobox protein Hox-2.8
Gene names
Name:Hoxb2
Synonyms:Hox-2.8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Subunit structure

Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Antp homeobox family. Proboscipedia subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from mutant phenotype PubMed 9012503. Source: MGI

dorsal/ventral pattern formation

Inferred from genetic interaction PubMed 10230789. Source: MGI

embryonic skeletal system morphogenesis

Inferred from genetic interaction PubMed 10885747. Source: MGI

facial nerve structural organization

Inferred from mutant phenotype PubMed 9012503. Source: MGI

morphogenesis of an epithelial sheet

Inferred from genetic interaction PubMed 11518511. Source: MGI

neural nucleus development

Inferred from mutant phenotype PubMed 9012503. Source: MGI

rhombomere 3 development

Inferred from genetic interaction PubMed 10230789. Source: MGI

rhombomere 4 development

Inferred from genetic interaction PubMed 10230789. Source: MGI

skeletal system morphogenesis

Inferred from mutant phenotype PubMed 9012503. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Homeobox protein Hox-B2
PRO_0000248841

Regions

DNA binding141 – 20060Homeobox
Motif92 – 976Antp-type hexapeptide

Sequences

Sequence LengthMass (Da)Tools
P0C1T1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: BA5EB460770DA045

FASTA35438,096
        10         20         30         40         50         60 
MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPLE QTFPSLQLGA 

        70         80         90        100        110        120 
STLQRPGSQK QAGDGPALRS PPPLPVAPPA PEFPWMKEKK STKKPSQSAA SPSPAASSVR 

       130        140        150        160        170        180 
ASEVGSPSDG PGLPECGGSG SRRLRTAYTN TQLLELEKEF HFNKYLCRPR RVEIAALLDL 

       190        200        210        220        230        240 
TERQVKVWFQ NRRMKHKRQT QHREPPEGEP GGPSAQDDAG EPAEEPTVSP GDVATHRLRE 

       250        260        270        280        290        300 
ACFHPAEAAQ GPRGAPPSAL PATTLESVGA SSPGCTMLRA GGRQSEPLPE DACPERQDSP 

       310        320        330        340        350 
FLPDLNFFAA DSCLQMSGGL SPSLQGSLDS PVPFSEEELD FFTSTLCAID LQFP 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL606824 Genomic DNA. Translation: CAM27581.1.
BC138494 mRNA. Translation: AAI38495.1.
BC138495 mRNA. Translation: AAI38496.1.
CCDSCCDS36290.1.
RefSeqNP_598793.2. NM_134032.2.
UniGeneMm.281153.

3D structure databases

ProteinModelPortalP0C1T1.
SMRP0C1T1. Positions 143-199.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000098092.

PTM databases

PhosphoSiteP0C1T1.

Proteomic databases

PRIDEP0C1T1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000100523; ENSMUSP00000098092; ENSMUSG00000075588.
GeneID103889.
KEGGmmu:103889.
UCSCuc007lby.1. mouse.

Organism-specific databases

CTD3212.
MGIMGI:96183. Hoxb2.

Phylogenomic databases

eggNOGNOG295272.
GeneTreeENSGT00750000117389.
HOGENOMHOG000063664.
HOVERGENHBG006088.
InParanoidP0C1T1.
KOK09302.
OMALEDICDP.
OrthoDBEOG73RBBF.
PhylomeDBP0C1T1.
TreeFamTF317730.

Gene expression databases

BgeeP0C1T1.
CleanExMM_HOXB2.
GenevestigatorP0C1T1.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio356175.
PROP0C1T1.
SOURCESearch...

Entry information

Entry nameHXB2_MOUSE
AccessionPrimary (citable) accession number: P0C1T1
Secondary accession number(s): A2A739, B9EHW9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries