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P0C1T1

- HXB2_MOUSE

UniProt

P0C1T1 - HXB2_MOUSE

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Protein

Homeobox protein Hox-B2

Gene

Hoxb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi141 – 20060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. dorsal/ventral pattern formation Source: MGI
  3. embryonic skeletal system morphogenesis Source: MGI
  4. facial nerve structural organization Source: MGI
  5. morphogenesis of an epithelial sheet Source: MGI
  6. neural nucleus development Source: MGI
  7. rhombomere 3 development Source: MGI
  8. rhombomere 4 development Source: MGI
  9. skeletal system morphogenesis Source: MGI
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B2
Alternative name(s):
Homeobox protein Hox-2.8
Gene namesi
Name:Hoxb2
Synonyms:Hox-2.8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96183. Hoxb2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Homeobox protein Hox-B2PRO_0000248841Add
BLAST

Proteomic databases

PRIDEiP0C1T1.

PTM databases

PhosphoSiteiP0C1T1.

Expressioni

Gene expression databases

BgeeiP0C1T1.
CleanExiMM_HOXB2.
GenevestigatoriP0C1T1.

Interactioni

Subunit structurei

Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098092.

Structurei

3D structure databases

ProteinModelPortaliP0C1T1.
SMRiP0C1T1. Positions 143-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi92 – 976Antp-type hexapeptide

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG295272.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000063664.
HOVERGENiHBG006088.
InParanoidiP0C1T1.
KOiK09302.
OMAiLEDICDP.
OrthoDBiEOG73RBBF.
PhylomeDBiP0C1T1.
TreeFamiTF317730.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C1T1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPLE
60 70 80 90 100
QTFPSLQLGA STLQRPGSQK QAGDGPALRS PPPLPVAPPA PEFPWMKEKK
110 120 130 140 150
STKKPSQSAA SPSPAASSVR ASEVGSPSDG PGLPECGGSG SRRLRTAYTN
160 170 180 190 200
TQLLELEKEF HFNKYLCRPR RVEIAALLDL TERQVKVWFQ NRRMKHKRQT
210 220 230 240 250
QHREPPEGEP GGPSAQDDAG EPAEEPTVSP GDVATHRLRE ACFHPAEAAQ
260 270 280 290 300
GPRGAPPSAL PATTLESVGA SSPGCTMLRA GGRQSEPLPE DACPERQDSP
310 320 330 340 350
FLPDLNFFAA DSCLQMSGGL SPSLQGSLDS PVPFSEEELD FFTSTLCAID

LQFP
Length:354
Mass (Da):38,096
Last modified:September 5, 2006 - v1
Checksum:iBA5EB460770DA045
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL606824 Genomic DNA. Translation: CAM27581.1.
BC138494 mRNA. Translation: AAI38495.1.
BC138495 mRNA. Translation: AAI38496.1.
CCDSiCCDS36290.1.
RefSeqiNP_598793.2. NM_134032.2.
UniGeneiMm.281153.

Genome annotation databases

EnsembliENSMUST00000100523; ENSMUSP00000098092; ENSMUSG00000075588.
GeneIDi103889.
KEGGimmu:103889.
UCSCiuc007lby.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL606824 Genomic DNA. Translation: CAM27581.1 .
BC138494 mRNA. Translation: AAI38495.1 .
BC138495 mRNA. Translation: AAI38496.1 .
CCDSi CCDS36290.1.
RefSeqi NP_598793.2. NM_134032.2.
UniGenei Mm.281153.

3D structure databases

ProteinModelPortali P0C1T1.
SMRi P0C1T1. Positions 143-199.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000098092.

PTM databases

PhosphoSitei P0C1T1.

Proteomic databases

PRIDEi P0C1T1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000100523 ; ENSMUSP00000098092 ; ENSMUSG00000075588 .
GeneIDi 103889.
KEGGi mmu:103889.
UCSCi uc007lby.1. mouse.

Organism-specific databases

CTDi 3212.
MGIi MGI:96183. Hoxb2.

Phylogenomic databases

eggNOGi NOG295272.
GeneTreei ENSGT00760000118940.
HOGENOMi HOG000063664.
HOVERGENi HBG006088.
InParanoidi P0C1T1.
KOi K09302.
OMAi LEDICDP.
OrthoDBi EOG73RBBF.
PhylomeDBi P0C1T1.
TreeFami TF317730.

Miscellaneous databases

NextBioi 356175.
PROi P0C1T1.
SOURCEi Search...

Gene expression databases

Bgeei P0C1T1.
CleanExi MM_HOXB2.
Genevestigatori P0C1T1.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiHXB2_MOUSE
AccessioniPrimary (citable) accession number: P0C1T1
Secondary accession number(s): A2A739, B9EHW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3