SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0C1Q2

- PDE11_MOUSE

UniProt

P0C1Q2 - PDE11_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Gene
Pde11a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively By similarity.1 Publication

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Enzyme regulationi

Inhibited by 3-isobutyl-1-methylxanthine (IBMX), zaprinast and dipyridamole. cGMP acts as an allosteric activator By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei664 – 6641Proton donor By similarity
Metal bindingi668 – 6681Divalent metal cation 1 By similarity
Metal bindingi704 – 7041Divalent metal cation 1 By similarity
Metal bindingi705 – 7051Divalent metal cation 1 By similarity
Metal bindingi705 – 7051Divalent metal cation 2 By similarity
Metal bindingi708 – 7081Divalent metal cation 2 By similarity
Metal bindingi734 – 7341Divalent metal cation 2 By similarity
Metal bindingi816 – 8161Divalent metal cation 1 By similarity
Binding sitei869 – 8691cAMP or cGMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
  2. cAMP binding Source: Ensembl
  3. cGMP binding Source: UniProtKB
  4. cGMP-stimulated cyclic-nucleotide phosphodiesterase activity Source: UniProtKB
  5. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cAMP catabolic process Source: Ensembl
  2. cGMP catabolic process Source: Ensembl
  3. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC:3.1.4.17, EC:3.1.4.35)
Alternative name(s):
cAMP and cGMP phosphodiesterase 11A
Gene namesi
Name:Pde11a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:3036251. Pde11a.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB-SubCell
  2. perikaryon Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Mice live well and have no impaired fertility. They do however display reduced sperm concentration, rate of forward progression and percentage of live spermatozoa. Pre-ejaculated sperm display increased premature/spontaneous capacitance.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 933933Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11APRO_0000247041Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei239 – 2391Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP0C1Q2.

PTM databases

PhosphoSiteiP0C1Q2.

Expressioni

Tissue specificityi

Expressed in testis and developing spermatoza.1 Publication

Gene expression databases

BgeeiP0C1Q2.
CleanExiMM_PDE11A.
GenevestigatoriP0C1Q2.

Structurei

3D structure databases

ProteinModelPortaliP0C1Q2.
SMRiP0C1Q2. Positions 205-911.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini217 – 370154GAF 1Add
BLAST
Domaini402 – 558157GAF 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni640 – 905266Catalytic By similarityAdd
BLAST

Domaini

The tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP stimulates enzyme activity By similarity.

Sequence similaritiesi

Contains 2 GAF domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG270709.
GeneTreeiENSGT00750000117253.
HOGENOMiHOG000007068.
HOVERGENiHBG101207.
InParanoidiP0C1Q2.
KOiK13298.
OMAiDYSDLMQ.
OrthoDBiEOG7RRF69.
PhylomeDBiP0C1Q2.
TreeFamiTF316499.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 2 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 2 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C1Q2-1 [UniParc]FASTAAdd to Basket

« Hide

MAASRLDFGE VETFLDRHPE LFEDYLMRKG KQELVDKWLQ RHTSGQGASS    50
LRPALAGASS LAQSNAKGSP GIGGGAGPQG SAHSHPTPGG GESAGVPLSP 100
SWASGSRGDG SLQRRASQKE LRKSFARSKA IHVNRTYDEQ VTSRAQEPLS 150
SVRRRALLRK ASSLPPTTAH ILSALLESRV NLPQYPPTAI DYKCHLKKHN 200
ERQFFLELVK DISNDLDLTS LSYKILIFVC LMVDADRCSL FLVEGAAAGK 250
KTLVSKFFDV HAGTPLLPCS STENSNEVQV PWGKGIIGYV GEHGETVNIP 300
DAYQDRRFND EIDKLTGYKT KSLLCMPIRN SDGEIIGVAQ AINKVPEGAP 350
FTEDDEKVMQ MYLPFCGIAI SNAQLFAASR KEYERSRALL EVVNDLFEEQ 400
TDLEKIVKKI MHRAQTLLKC ERCSVLLLED IESPVVKFTK SFELMSPKCS 450
ADAENSFKES VEKSSYSDWL INNSIAELVA STGLPVNVSD AYQDPRFDAE 500
ADQISGFHIR SVLCVPIWNS NHQIIGVAQV LNRLDGKPFD DADQRLFEAF 550
VIFCGLGINN TIMYDQVKKS WAKQSVALDV LSYHATCSKA EVDKFKAANI 600
PLVSELAIDD IHFDDFSLDV DAMITAALRM FMELGMVQKF KIDYETLCRW 650
LLTVRKNYRM VLYHNWRHAF NVCQLMFAML TTAGFQEILT EVEILAVIVG 700
CLCHDLDHRG TNNAFQAKSD SALAQLYGTS ATLEHHHFNH AVMILQSEGH 750
NIFANLSSKE YSDLMQLLKQ SILATDLTLY FERRTEFFEL VRKGDYDWSI 800
TSHRDVFRSM LMTACDLGAV TKPWEISRQV AELVTSEFFE QGDRERSELK 850
LTPSAIFDRN RKDELPRLQL EWIDSICMPL YQALVKVNAK LKPMLDSVAA 900
NRRKWEELHQ KRLQVSAASP DPASPMVAGE DRL 933
Length:933
Mass (Da):104,563
Last modified:July 25, 2006 - v1
Checksum:i07B7CA1E4F905755
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL772341, AL845373, AL929133 Genomic DNA. Translation: CAM16587.1.
AL845373, AL772341, AL929133 Genomic DNA. Translation: CAM17618.1.
AL929133, AL772341, AL845373 Genomic DNA. Translation: CAM23980.1.
AL929589 Genomic DNA. No translation available.
CCDSiCCDS38152.1.
RefSeqiNP_001074502.1. NM_001081033.1.
UniGeneiMm.246613.

Genome annotation databases

EnsembliENSMUST00000099992; ENSMUSP00000097572; ENSMUSG00000075270.
GeneIDi241489.
KEGGimmu:241489.
UCSCiuc008kex.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL772341 , AL845373 , AL929133 Genomic DNA. Translation: CAM16587.1 .
AL845373 , AL772341 , AL929133 Genomic DNA. Translation: CAM17618.1 .
AL929133 , AL772341 , AL845373 Genomic DNA. Translation: CAM23980.1 .
AL929589 Genomic DNA. No translation available.
CCDSi CCDS38152.1.
RefSeqi NP_001074502.1. NM_001081033.1.
UniGenei Mm.246613.

3D structure databases

ProteinModelPortali P0C1Q2.
SMRi P0C1Q2. Positions 205-911.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P0C1Q2.

Proteomic databases

PRIDEi P0C1Q2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000099992 ; ENSMUSP00000097572 ; ENSMUSG00000075270 .
GeneIDi 241489.
KEGGi mmu:241489.
UCSCi uc008kex.1. mouse.

Organism-specific databases

CTDi 50940.
MGIi MGI:3036251. Pde11a.

Phylogenomic databases

eggNOGi NOG270709.
GeneTreei ENSGT00750000117253.
HOGENOMi HOG000007068.
HOVERGENi HBG101207.
InParanoidi P0C1Q2.
KOi K13298.
OMAi DYSDLMQ.
OrthoDBi EOG7RRF69.
PhylomeDBi P0C1Q2.
TreeFami TF316499.

Miscellaneous databases

NextBioi 385015.
PROi P0C1Q2.
SOURCEi Search...

Gene expression databases

Bgeei P0C1Q2.
CleanExi MM_PDE11A.
Genevestigatori P0C1Q2.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 2 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 2 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology."
    Wayman C., Phillips S., Lunny C., Webb T., Fawcett L., Baxendale R., Burgess G.
    Int. J. Impot. Res. 17:216-223(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiPDE11_MOUSE
AccessioniPrimary (citable) accession number: P0C1Q2
Secondary accession number(s): A2AKR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi