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Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y

Gene

Pigy

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. May act by regulating the catalytic subunit PIGA (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Biological processi

Keywordsi

Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class Y protein
Short name:
PIG-Y
Gene namesi
Name:Pigy
Synonyms:Pigyl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1913518. Pigyl.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5CytoplasmicSequence analysis5
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Topological domaini27 – 44LumenalSequence analysisAdd BLAST18
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 71CytoplasmicSequence analysis6

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002463121 – 71Phosphatidylinositol N-acetylglucosaminyltransferase subunit YAdd BLAST71

Proteomic databases

PaxDbiP0C1P0.
PRIDEiP0C1P0.

PTM databases

iPTMnetiP0C1P0.
PhosphoSitePlusiP0C1P0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000010607.
GenevisibleiP0C1P0. MM.

Interactioni

Subunit structurei

Interacts with the GPI-GnT complex composed of PIGA, PIGC, PIGH, PIGP, PIGQ and DPM2. Interacts directly with PIGA. Does not interact with Ras proteins (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116929.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JDU7. Eukaryota.
ENOG4111BVT. LUCA.
GeneTreeiENSGT00610000087446.
HOVERGENiHBG082140.
InParanoidiP0C1P0.
KOiK11001.
OMAiPQDCTST.
OrthoDBiEOG091G15RT.

Family and domain databases

InterProiView protein in InterPro
IPR029164. PIG-Y.
IPR033535. PIGY_chordates.
PANTHERiPTHR39235. PTHR39235. 1 hit.
PfamiView protein in Pfam
PF15159. PIG-Y. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C1P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRSLPTMTV LIPLVSLAGL LYSASVEEGF PEGCTSASSL CFYSLLLPVT
60 70
VPVYVFFHLW TWMGLKLFRH N
Length:71
Mass (Da):7,952
Last modified:July 25, 2006 - v1
Checksum:i88CC7F21C2CCF5B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021110 mRNA. No translation available.
AC159308 mRNA. No translation available.
CCDSiCCDS52742.1.
RefSeqiNP_001076001.1. NM_001082532.1.
UniGeneiMm.28924.

Genome annotation databases

EnsembliENSMUST00000123680; ENSMUSP00000116929; ENSMUSG00000010607.
ENSMUST00000148088; ENSMUSP00000116967; ENSMUSG00000010607.
GeneIDi66268.
KEGGimmu:66268.
UCSCiuc009ooc.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPIGY_MOUSE
AccessioniPrimary (citable) accession number: P0C1P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: July 5, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways