Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y

Gene

Pigy

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. May act by regulating the catalytic subunit PIGA (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class Y protein
Short name:
PIG-Y
Gene namesi
Name:Pigy
Synonyms:Pigyl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1913518. Pigyl.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55CytoplasmicSequence analysis
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Topological domaini27 – 4418LumenalSequence analysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence analysisAdd
BLAST
Topological domaini66 – 716CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7171Phosphatidylinositol N-acetylglucosaminyltransferase subunit YPRO_0000246312Add
BLAST

Proteomic databases

PaxDbiP0C1P0.

PTM databases

iPTMnetiP0C1P0.
PhosphoSiteiP0C1P0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000010607.
GenevisibleiP0C1P0. MM.

Interactioni

Subunit structurei

Interacts with the GPI-GnT complex composed of PIGA, PIGC, PIGH, PIGP, PIGQ and DPM2. Interacts directly with PIGA. Does not interact with Ras proteins (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116929.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JDU7. Eukaryota.
ENOG4111BVT. LUCA.
GeneTreeiENSGT00610000087446.
HOVERGENiHBG082140.
InParanoidiP0C1P0.
KOiK11001.
OMAiFPEGCTS.
OrthoDBiEOG091G15RT.

Family and domain databases

InterProiIPR029164. PIG-Y.
IPR033535. PIGY_ver.
[Graphical view]
PANTHERiPTHR39235. PTHR39235. 1 hit.
PfamiPF15159. PIG-Y. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C1P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRSLPTMTV LIPLVSLAGL LYSASVEEGF PEGCTSASSL CFYSLLLPVT
60 70
VPVYVFFHLW TWMGLKLFRH N
Length:71
Mass (Da):7,952
Last modified:July 25, 2006 - v1
Checksum:i88CC7F21C2CCF5B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021110 mRNA. No translation available.
AC159308 mRNA. No translation available.
CCDSiCCDS52742.1.
RefSeqiNP_001076001.1. NM_001082532.1.
UniGeneiMm.28924.

Genome annotation databases

EnsembliENSMUST00000123680; ENSMUSP00000116929; ENSMUSG00000010607.
ENSMUST00000148088; ENSMUSP00000116967; ENSMUSG00000010607.
GeneIDi66268.
KEGGimmu:66268.
UCSCiuc009ooc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021110 mRNA. No translation available.
AC159308 mRNA. No translation available.
CCDSiCCDS52742.1.
RefSeqiNP_001076001.1. NM_001082532.1.
UniGeneiMm.28924.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116929.

PTM databases

iPTMnetiP0C1P0.
PhosphoSiteiP0C1P0.

Proteomic databases

PaxDbiP0C1P0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000123680; ENSMUSP00000116929; ENSMUSG00000010607.
ENSMUST00000148088; ENSMUSP00000116967; ENSMUSG00000010607.
GeneIDi66268.
KEGGimmu:66268.
UCSCiuc009ooc.1. mouse.

Organism-specific databases

CTDi66268.
MGIiMGI:1913518. Pigyl.

Phylogenomic databases

eggNOGiENOG410JDU7. Eukaryota.
ENOG4111BVT. LUCA.
GeneTreeiENSGT00610000087446.
HOVERGENiHBG082140.
InParanoidiP0C1P0.
KOiK11001.
OMAiFPEGCTS.
OrthoDBiEOG091G15RT.

Enzyme and pathway databases

UniPathwayiUPA00196.

Miscellaneous databases

PROiP0C1P0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010607.
GenevisibleiP0C1P0. MM.

Family and domain databases

InterProiIPR029164. PIG-Y.
IPR033535. PIGY_ver.
[Graphical view]
PANTHERiPTHR39235. PTHR39235. 1 hit.
PfamiPF15159. PIG-Y. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIGY_MOUSE
AccessioniPrimary (citable) accession number: P0C1P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.