P0C1J2 (CWC27_RHIOR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl isomerase cwc27
Short name=PPIase cwc27
EC=5.2.1.8

Alternative name(s):
Rotamase cwc27

Gene names

Name:	cwc27
ORF Names:	RO3G_04513

Organism

Rhizopus oryzae (Rhizopus delemar)

Taxonomic identifier

64495 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Fungi incertae sedis › Basal fungal lineages › Mucoromycotina › Mucorales › Mucoraceae › Rhizopus

Protein attributes

Sequence length	524 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subunit structure	Associated with the spliceosome By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the cyclophilin-type PPIase family. CWC27 subfamily. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Cytoplasm Nucleus Spliceosome
Molecular function	Isomerase Rotamase
Gene Ontology (GO)
Biological process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell spliceosomal complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 524	524	Peptidyl-prolyl isomerase cwc27		PRO_0000244725
Regions
	Domain	11 – 166	156	PPIase cyclophilin-type
	Compositional bias	183 – 389	207	Glu/Lys-rich
	Compositional bias	482 – 486	5	Poly-Ser
	Compositional bias	488 – 524	37	Arg-rich

Sequences

	Sequence		Length	Mass (Da)
	P0C1J2 [UniParc]. Last modified June 27, 2006. Version 1. Checksum: 087BDD7CF342A2D5	FASTA	524	61,050
	10 20 30 40 50 60 MSNIYALEPH TNAKVILHTT SGDIEIELWG KEAPRATRNF IQLCLEGYYD NTIFHRIVPG 70 80 90 100 110 120 FLVQGGDPTG TGQGGESVYE DGFPDEFHSR LRFNRRGLVG VANTGQNDNG SQFFITLDRA 130 140 150 160 170 180 DELTKRHTLF GRVAGDTLFN VMKMTELEID ENERPLYPPR IKRTEIVINP FDDILPRITE 190 200 210 220 230 240 REKRQQKELE KKKMLEEAKK KKAPKKKQLN LLSFGEEAAE LEPPSHTVEK TKMKSAYDFM 250 260 270 280 290 300 ETSAPTPTEL IEELKKPVKE ESTVISEKKD DAKQEEENKK AEEEERKRKK ALEEERKRQK 310 320 330 340 350 360 EEEKKKMQEN TSESRASAIE KLKQDIRNLS KTSSNTSDEL IPKKDKKRSL VELEREKYAS 370 380 390 400 410 420 QKRKKMKKGD DTDVFNKLMS FQKKLSTAKE DEDAAAAKRD QPPCEIHGIP GCESCRDTTQ 430 440 450 460 470 480 DAEEDVSDAG WISHKLIFEK DLKGKDLMKR RETVDDYVVI DPRDREAKAK QEEYERKKGI 490 500 510 520 KSSSSSQRRD RMDHDDKRYR TEKRSRSDRH RRSRSRDRYD DRRR

References

[1]	"The genome sequence of Rhizopus oryzae RA 99-880." Lander E.S., Birren B.W., Ma L.-J., Ibrahim A.S., Skory C.D., Wickes B.L., Lang F. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC 9543 / RA 99-880.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACW02000073 Genomic DNA. No translation available.
3D structure databases
ProteinModelPortal	P0C1J2.
SMR	P0C1J2. Positions 8-172.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
PhylomeDB	P0C1J2.
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. IPR020892. Cyclophilin-type_PPIase_CS. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CWC27_RHIOR

Accession

Primary (citable) accession number: P0C1J2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program