P0C1J0 (CYP15_RHIOR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase cyp15
Short name=PPIase cyp15
EC=5.2.1.8

Alternative name(s):
Cyclophilin cyp15
Rotamase cyp15

Gene names

Name:	cyp15
ORF Names:	RO3G_14919

Organism

Rhizopus oryzae (Rhizopus delemar)

Taxonomic identifier

64495 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Fungi incertae sedis › Basal fungal lineages › Mucoromycotina › Mucorales › Mucoraceae › Rhizopus

Protein attributes

Sequence length	630 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Sequence similarities	Belongs to the cyclophilin-type PPIase family. Contains 1 PPIase cyclophilin-type domain. Contains 5 WD repeats.

Ontologies

Keywords
Domain	Repeat WD repeat
Molecular function	Isomerase Rotamase
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 630	630	Peptidyl-prolyl cis-trans isomerase cyp15		PRO_0000244723
Regions
	Repeat	70 – 108	39	WD 1
	Repeat	113 – 152	40	WD 2
	Repeat	157 – 198	42	WD 3
	Repeat	203 – 242	40	WD 4
	Repeat	258 – 301	44	WD 5
	Domain	475 – 629	155	PPIase cyclophilin-type
	Compositional bias	34 – 37	4	Poly-Pro

Sequences

	Sequence		Length	Mass (Da)
	P0C1J0 [UniParc]. Last modified June 27, 2006. Version 1. Checksum: 1B357E58EDBDAD47	FASTA	630	71,282
	10 20 30 40 50 60 MPEDSNTNDN NKRPLEDNNA VDGESDDDIG PMLPPPPGED APRKKKRTLA HEKLYLDQLP 70 80 90 100 110 120 CADMYEKSYM HRDVLSQVAV TKKDFIITTS VDGHLKFWKK TASGIEFVKH YKSHLSSIVD 130 140 150 160 170 180 ISISANHELL ATISDDTTLK VYDITNFDMI NMIKLRYKPK SVCWIHQSGQ AQALVAVSEA 190 200 210 220 230 240 DNSNIHIYDG HADGKPLHTL SKMHSKPVHI IEFNSRFNCV VSVDAIGMIE YWSPEAPFAL 250 260 270 280 290 300 PDNLDFELKS QTDLYEFRKK KSVPTCLTFS PDGLSFATMS FPDRQVRLFK FLRGKMFREY 310 320 330 340 350 360 DESLQAVSEM QQAGTTIHHL DDMEFGRRLA VEKELEKSNQ ARFVNAVFDN SGNFIIYGSL 370 380 390 400 410 420 LGVKIVNIRT NKVVCLLGKS ESNRFVNVSL YQGAPKKKAV YTLAMIASEN AALKESQELD 430 440 450 460 470 480 PTLFCTAFNK NRFYMMTRRE PFDDINQKAE RDIFNEKPSR EEQTVAATQE RKQILGTSAI 490 500 510 520 530 540 IRTTSGDIHM RLFPDAAPKA VENFTTHAKN GYYDNLIFHR VIKGFMIQTG CPFGDGTGGE 550 560 570 580 590 600 SIWGDDFEDE FSREFRHDRP YTVSMANAGP NTNGSQFFIT VAPTTWLDNK HSVFGRVTAG 610 620 630 MDVVHSIESA KVDKTNKPLD DIKIINIDIR

References

[1]	"The genome sequence of Rhizopus oryzae RA 99-880." Lander E.S., Birren B.W., Ma L.-J., Ibrahim A.S., Skory C.D., Wickes B.L., Lang F. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC 9543 / RA 99-880.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACW02000274 Genomic DNA. No translation available.
3D structure databases
ProteinModelPortal	P0C1J0.
SMR	P0C1J0. Positions 478-630.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
PhylomeDB	P0C1J0.
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. IPR020892. Cyclophilin-type_PPIase_CS. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit. G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00160. Pro_isomerase. 1 hit. PF00400. WD40. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
SMART	SM00320. WD40. 4 hits. [Graphical view]
SUPFAM	SSF50891. CSA_PPIase. 1 hit. SSF50978. WD40_like. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYP15_RHIOR

Accession

Primary (citable) accession number: P0C1J0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program