P0C1I9 (CYP11_RHIOR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase cyp11
Short name=PPIase cyp11
EC=5.2.1.8

Alternative name(s):
Cyclophilin cyp11
Rotamase cyp11

Gene names

Name:	cyp11
ORF Names:	RO3G_13323

Organism

Rhizopus oryzae (Rhizopus delemar)

Taxonomic identifier

64495 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Fungi incertae sedis › Basal fungal lineages › Mucoromycotina › Mucorales › Mucoraceae › Rhizopus

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Sequence similarities	Belongs to the cyclophilin-type PPIase family. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Molecular function	Isomerase Rotamase
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Peptidyl-prolyl cis-trans isomerase cyp11		PRO_0000244722
Regions
	Domain	7 – 172	166	PPIase cyclophilin-type
	Compositional bias	217 – 220	4	Poly-Glu
	Compositional bias	234 – 241	8	Poly-Lys

Sequences

	Sequence		Length	Mass (Da)
	P0C1I9 [UniParc]. Last modified June 27, 2006. Version 1. Checksum: 4500A1482E987432	FASTA	338	39,077
	10 20 30 40 50 60 MINPRVFFDI DVDGNRIGRI VIELFADQVP KTAENFRALC TGEKGIGKVS NMPLHYKGSI 70 80 90 100 110 120 FHRIIKGFMC QGGDFTHRTG KGGESIYGAN FPDESFSRKH DTHGLLSMAN RGPNTQTSQF 130 140 150 160 170 180 FITTRPTPHL DGKHVVFGRV VSGYNVVEMM ENEPVDDQDR PLHNVMIANC GELVLKLPPG 190 200 210 220 230 240 ALLKKASAVS DESEDEIKNR KRSRSSDDDS SSDEDSEEEE RKRTKKKRSR KHSKKDKKKK 250 260 270 280 290 300 KRESSNRKRS PEANRHVSRE RRDISREKRD NSRERRLSRK EDDRRSPSDK RKEDRRSLSP 310 320 330 EKRSSERRVA RPVRPRLNYN DPNVEVKGRG RFKYRPTY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Rhizopus oryzae RA 99-880." Lander E.S., Birren B.W., Ma L.-J., Ibrahim A.S., Skory C.D., Wickes B.L., Lang F. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC 9543 / RA 99-880.
[2]	Pemberton T.J. Submitted (MAY-2006) to UniProtKB Cited for: REVISION OF GENE MODEL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACW02000245 Genomic DNA. No translation available.
3D structure databases
ProteinModelPortal	P0C1I9.
SMR	P0C1I9. Positions 3-173.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. IPR020892. Cyclophilin-type_PPIase_CS. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYP11_RHIOR

Accession

Primary (citable) accession number: P0C1I9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program