Reviewed, UniProtKB/Swiss-Prot P0C1I8 (CYP6_RHIOR)

Names and origin

Protein names

Recommended name:
    Peptidyl-prolyl cis-trans isomerase cyp6
      Short name=PPIase cyp6
      Short name=Rotamase cyp6
    EC=5.2.1.8
Alternative name(s):
    Cyclophilin cyp6

Gene names

Name:	cyp6
ORF Names:	RO3G_10072

Organism

Rhizopus oryzae (Rhizopus delemar)

Taxonomic identifier

64495 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Fungi incertae sedis › Basal fungal lineages › Mucoromycotina › Mucorales › Mucoraceae › Rhizopus

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Sequence similarities	Belongs to the cyclophilin-type PPIase family. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Molecular function	Isomerase Rotamase
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 176	176	Peptidyl-prolyl cis-trans isomerase cyp6		PRO_0000244721
Regions
	Domain	10 – 173	164	PPIase cyclophilin-type

Sequences

	Sequence		Length	Mass (Da)
	P0C1I8-1 [UniParc]. Last modified June 27, 2006. Version 1. Checksum: 099AE41C28FDFD73	FASTA	176	19,198
	10 20 30 40 50 60 MAAKNLPKVF FDIAVNGQHS GRMTFKLFSD TVPKTAENFR ALCTGEKGKG ISGKPLHYKN 70 80 90 100 110 120 SYFHRIIPGF MAQGGDFTMG DGRGGESIYG RTFKDENFTL KHKGKGLLSM ANAGPNTNGS 130 140 150 160 170 QFFITFVDTP WLDGNHTVFG QIVDGSKVLD LLEQHGSRSG MPSAKIEITD CGELKD

References

[1]	"The genome sequence of Rhizopus oryzae RA 99-880." Lander E.S., Birren B.W., Ma L.-J., Ibrahim A.S., Skory C.D., Wickes B.L., Lang F. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC 9543 / RA 99-880.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACW02000177 Genomic DNA. No translation available.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	5.2.1.8. 141574.
Family and domain databases
InterPro	IPR002130. PPIase_cyclophilin. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYP6_RHIOR

Accession

Primary (citable) accession number: P0C1I8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	June 16, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)