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Protein

Histone H2B type F-M

Gene

H2BFM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2B type F-M
Alternative name(s):
Histone H2B.s
Short name:
H2B/s
Gene namesi
Name:H2BFM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:27867. H2BFM.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi286436.
OpenTargetsiENSG00000101812.
PharmGKBiPA142671702.

Polymorphism and mutation databases

DMDMi110279004.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002448271 – 154Histone H2B type F-MAdd BLAST154

Proteomic databases

PaxDbiP0C1H6.
PeptideAtlasiP0C1H6.
PRIDEiP0C1H6.

PTM databases

PhosphoSitePlusiP0C1H6.

Expressioni

Gene expression databases

BgeeiENSG00000101812.
CleanExiHS_H2BFM.
ExpressionAtlasiP0C1H6. baseline and differential.
GenevisibleiP0C1H6. HS.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Protein-protein interaction databases

BioGridi130376. 1 interactor.
STRINGi9606.ENSP00000347119.

Structurei

3D structure databases

ProteinModelPortaliP0C1H6.
SMRiP0C1H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00860000133714.
HOGENOMiHOG000112843.
HOVERGENiHBG081589.
InParanoidiP0C1H6.
KOiK11252.
OMAiPKEANSM.
OrthoDBiEOG091G0WZB.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C1H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAASAMAEA SSETTSEEGQ SIQEPKEANS TKAQKQKRRG CRGSRRRHAN
60 70 80 90 100
RRGDSFGDSF TPYFPRVLKQ VHQGLSLSQE AVSVMDSMIH DILDRIATEA
110 120 130 140 150
GQLAHYTKRV TITSRDIQMA VRLLLPGKMG KLAEAQGTNA ALRTSLCAIW

QQRK
Length:154
Mass (Da):17,001
Last modified:April 16, 2014 - v2
Checksum:i700C131F5F5818B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093522 mRNA. No translation available.
Z73497 Genomic DNA. No translation available.
CCDSiCCDS55468.1.
RefSeqiNP_001157888.1. NM_001164416.1.
XP_006724703.1. XM_006724640.2.
XP_011529224.1. XM_011530922.2.
UniGeneiHs.376474.

Genome annotation databases

EnsembliENST00000355016; ENSP00000347119; ENSG00000101812.
ENST00000598335; ENSP00000482611; ENSG00000101812.
GeneIDi286436.
KEGGihsa:286436.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093522 mRNA. No translation available.
Z73497 Genomic DNA. No translation available.
CCDSiCCDS55468.1.
RefSeqiNP_001157888.1. NM_001164416.1.
XP_006724703.1. XM_006724640.2.
XP_011529224.1. XM_011530922.2.
UniGeneiHs.376474.

3D structure databases

ProteinModelPortaliP0C1H6.
SMRiP0C1H6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130376. 1 interactor.
STRINGi9606.ENSP00000347119.

PTM databases

PhosphoSitePlusiP0C1H6.

Polymorphism and mutation databases

DMDMi110279004.

Proteomic databases

PaxDbiP0C1H6.
PeptideAtlasiP0C1H6.
PRIDEiP0C1H6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355016; ENSP00000347119; ENSG00000101812.
ENST00000598335; ENSP00000482611; ENSG00000101812.
GeneIDi286436.
KEGGihsa:286436.

Organism-specific databases

CTDi286436.
DisGeNETi286436.
GeneCardsiH2BFM.
HGNCiHGNC:27867. H2BFM.
neXtProtiNX_P0C1H6.
OpenTargetsiENSG00000101812.
PharmGKBiPA142671702.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00860000133714.
HOGENOMiHOG000112843.
HOVERGENiHBG081589.
InParanoidiP0C1H6.
KOiK11252.
OMAiPKEANSM.
OrthoDBiEOG091G0WZB.

Miscellaneous databases

GeneWikiiH2BFM.
GenomeRNAii286436.
PROiP0C1H6.

Gene expression databases

BgeeiENSG00000101812.
CleanExiHS_H2BFM.
ExpressionAtlasiP0C1H6. baseline and differential.
GenevisibleiP0C1H6. HS.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiH2BFM_HUMAN
AccessioniPrimary (citable) accession number: P0C1H6
Secondary accession number(s): A6NP82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: April 16, 2014
Last modified: November 30, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In contrast to other H2B histones, it does not contain the conserved residue in C-terminus that is the target of monoubiquitination.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.