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Protein

Histone H2B 7

Gene

H2B-VII

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-GGA-171306 Packaging Of Telomere Ends
R-GGA-201722 Formation of the beta-catenin:TCF transactivating complex
R-GGA-212300 PRC2 methylates histones and DNA
R-GGA-2299718 Condensation of Prophase Chromosomes
R-GGA-2559580 Oxidative Stress Induced Senescence
R-GGA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-GGA-3214847 HATs acetylate histones
R-GGA-5250924 B-WICH complex positively regulates rRNA expression
R-GGA-5578749 Transcriptional regulation by small RNAs
R-GGA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-GGA-5693571 Nonhomologous End-Joining (NHEJ)
R-GGA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-GGA-69473 G2/M DNA damage checkpoint
R-GGA-73728 RNA Polymerase I Promoter Opening
R-GGA-73777 RNA Polymerase I Chain Elongation
R-GGA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-GGA-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2B 7
Alternative name(s):
H2B VII
Gene namesi
Name:H2B-VII
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002448652 – 126Histone H2B 7Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6N6-acetyllysine1 Publication1
Modified residuei13N6-acetyllysine1 Publication1
Modified residuei15Phosphoserine1 Publication1
Modified residuei16N6-acetyllysine1 Publication1
Modified residuei21N6-acetyllysine1 Publication1
Glycosylationi113O-linked (GlcNAc) serineBy similarity1
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

Monoubiquitination of Lys-121 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.By similarity
Phosphorylated on Ser-15 during apoptosis; which facilitates apoptotic chromatin condensation.1 Publication
GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiP0C1H5

PTM databases

iPTMnetiP0C1H5

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiP0C1H5, 1 interactor

Structurei

Secondary structure

1126
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi39 – 49Combined sources11
Helixi57 – 84Combined sources28
Beta strandi88 – 90Combined sources3
Helixi92 – 102Combined sources11
Helixi105 – 124Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EQZX-ray2.50B/F1-126[»]
1HIOX-ray3.10B37-126[»]
1HQ3X-ray2.15B/F1-126[»]
1TZYX-ray1.90B/F1-126[»]
2HIOX-ray3.10B2-126[»]
3C9Kelectron microscopy20.00B/F2-126[»]
ProteinModelPortaliP0C1H5
SMRiP0C1H5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C1H5

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGiKOG1744 Eukaryota
ENOG4111NV5 LUCA
GeneTreeiENSGT00760000118976
HOVERGENiHBG007774
InParanoidiP0C1H5

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000558 Histone_H2B
PANTHERiPTHR23428 PTHR23428, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00621 HISTONEH2B
SMARTiView protein in SMART
SM00427 H2B, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00357 HISTONE_H2B, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C1H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEPAKSAPA PKKGSKKAVT KTQKKGDKKR KRARKESYSI YVYKVLKQVH
60 70 80 90 100
PDTGISSKAM SIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR
110 120
LLLPGELAKH AVSEGTKAVT KYTSSK
Length:126
Mass (Da):13,964
Last modified:January 23, 2007 - v2
Checksum:iB14EC3822B5DAA97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05099 Genomic DNA Translation: CAA28750.1
U37575 Genomic DNA Translation: AAC60000.1
RefSeqiXP_015144978.1, XM_015289492.1
UniGeneiGga.39843

Genome annotation databases

EnsembliENSGALT00000073535; ENSGALP00000055900; ENSGALG00000036908
GeneIDi107053803
KEGGigga:107053803

Similar proteinsi

Entry informationi

Entry nameiH2B7_CHICK
AccessioniPrimary (citable) accession number: P0C1H5
Secondary accession number(s): P02279
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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