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Protein

Histone H2B 1/2/3/4/6

Gene

H2B-I

more
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.1 Publication
Has broad-spectrum antibacterial activity. May be important in the antimicrobial defenses of chick reproductive system during follicle development in the ovary and egg formation in the oviduct.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, DNA-binding

Enzyme and pathway databases

ReactomeiR-GGA-3214847. HATs acetylate histones.
R-GGA-5689880. Ub-specific processing proteases.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2B 1/2/3/4/6
Alternative name(s):
H2B I
H2B II
H2B III
H2B IV
H2B VI
Gene namesi
Name:H2B-I
AND
Name:H2B-II
AND
Name:H2B-III
AND
Name:H2B-IV
AND
Name:H2B-VI
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000718462 – 126Histone H2B 1/2/3/4/6Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6N6-acetyllysine1 Publication1
Modified residuei13N6-acetyllysine1 Publication1
Modified residuei15Phosphoserine1 Publication1
Modified residuei16N6-acetyllysine1 Publication1
Modified residuei21N6-acetyllysine1 Publication1
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

Monoubiquitination of Lys-121 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.By similarity
Phosphorylated on Ser-15 during apoptosis; which facilitates apoptotic chromatin condensation.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP0C1H3.
PRIDEiP0C1H3.

PTM databases

iPTMnetiP0C1H3.

Expressioni

Gene expression databases

BgeeiENSGALG00000027174.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi679231. 3 interactors.
IntActiP0C1H3. 1 interactor.
STRINGi9031.ENSGALP00000037300.

Structurei

Secondary structure

1126
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi39 – 49Combined sources11
Helixi57 – 84Combined sources28
Beta strandi88 – 90Combined sources3
Helixi92 – 102Combined sources11
Helixi105 – 124Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AROX-ray2.10B/F1-126[»]
ProteinModelPortaliP0C1H3.
SMRiP0C1H3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C1H3.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00760000118976.
HOGENOMiHOG000231213.
HOVERGENiHBG007774.
InParanoidiP0C1H3.
KOiK11252.
OMAiNKSHEMP.
OrthoDBiEOG091G0XGD.
PhylomeDBiP0C1H3.
TreeFamiTF300212.

Family and domain databases

InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PRINTSiPR00621. HISTONEH2B.
SMARTiView protein in SMART
SM00427. H2B. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00357. HISTONE_H2B. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C1H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEPAKSAPA PKKGSKKAVT KTQKKGDKKR KKSRKESYSI YVYKVLKQVH
60 70 80 90 100
PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR
110 120
LLLPGELAKH AVSEGTKAVT KYTSSK
Length:126
Mass (Da):13,922
Last modified:January 23, 2007 - v2
Checksum:i908F039A02A3400D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14G → A in CAA28745 (PubMed:3822819).Curated1
Sequence conflicti36E → A in CAA28747 (PubMed:3822819).Curated1
Sequence conflicti62I → S AA sequence (PubMed:7074112).Curated1
Sequence conflicti123T → I in CAA28751 (PubMed:3822819).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00415 Genomic DNA. Translation: CAA23706.1.
X05094 Genomic DNA. Translation: CAA28745.1.
X05095 Genomic DNA. Translation: CAA28746.1.
X05096 Genomic DNA. Translation: CAA28747.1.
X05097 Genomic DNA. Translation: CAA28748.1.
X05098 Genomic DNA. Translation: CAA28749.1.
X05100 Genomic DNA. Translation: CAA28751.1.
X57263 Genomic DNA. Translation: CAA40537.1.
X07763 Genomic DNA. Translation: CAA30590.1.
X07766 Genomic DNA. Translation: CAA30596.1.
PIRiB26399.
S14510. HSCH22.
RefSeqiNP_001073188.1. NM_001079720.1.
XP_001232985.1. XM_001232984.3.
XP_001233227.1. XM_001233226.4.
XP_001233337.1. XM_001233336.4.
UniGeneiGga.39843.
Gga.40038.

Genome annotation databases

EnsembliENSGALT00000021778; ENSGALP00000021742; ENSGALG00000042263.
ENSGALT00000042841; ENSGALP00000042437; ENSGALG00000027594.
ENSGALT00000043224; ENSGALP00000042501; ENSGALG00000027571.
ENSGALT00000052037; ENSGALP00000053434; ENSGALG00000039722.
ENSGALT00000054609; ENSGALP00000054120; ENSGALG00000037934.
GeneIDi417956.
769973.
770188.
770267.
KEGGigga:417956.
gga:769973.
gga:770188.
gga:770267.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00415 Genomic DNA. Translation: CAA23706.1.
X05094 Genomic DNA. Translation: CAA28745.1.
X05095 Genomic DNA. Translation: CAA28746.1.
X05096 Genomic DNA. Translation: CAA28747.1.
X05097 Genomic DNA. Translation: CAA28748.1.
X05098 Genomic DNA. Translation: CAA28749.1.
X05100 Genomic DNA. Translation: CAA28751.1.
X57263 Genomic DNA. Translation: CAA40537.1.
X07763 Genomic DNA. Translation: CAA30590.1.
X07766 Genomic DNA. Translation: CAA30596.1.
PIRiB26399.
S14510. HSCH22.
RefSeqiNP_001073188.1. NM_001079720.1.
XP_001232985.1. XM_001232984.3.
XP_001233227.1. XM_001233226.4.
XP_001233337.1. XM_001233336.4.
UniGeneiGga.39843.
Gga.40038.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AROX-ray2.10B/F1-126[»]
ProteinModelPortaliP0C1H3.
SMRiP0C1H3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi679231. 3 interactors.
IntActiP0C1H3. 1 interactor.
STRINGi9031.ENSGALP00000037300.

PTM databases

iPTMnetiP0C1H3.

Proteomic databases

PaxDbiP0C1H3.
PRIDEiP0C1H3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000021778; ENSGALP00000021742; ENSGALG00000042263.
ENSGALT00000042841; ENSGALP00000042437; ENSGALG00000027594.
ENSGALT00000043224; ENSGALP00000042501; ENSGALG00000027571.
ENSGALT00000052037; ENSGALP00000053434; ENSGALG00000039722.
ENSGALT00000054609; ENSGALP00000054120; ENSGALG00000037934.
GeneIDi417956.
769973.
770188.
770267.
KEGGigga:417956.
gga:769973.
gga:770188.
gga:770267.

Organism-specific databases

CTDi417956.
770188.
770267.
8343.

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00760000118976.
HOGENOMiHOG000231213.
HOVERGENiHBG007774.
InParanoidiP0C1H3.
KOiK11252.
OMAiNKSHEMP.
OrthoDBiEOG091G0XGD.
PhylomeDBiP0C1H3.
TreeFamiTF300212.

Enzyme and pathway databases

ReactomeiR-GGA-3214847. HATs acetylate histones.
R-GGA-5689880. Ub-specific processing proteases.

Miscellaneous databases

EvolutionaryTraceiP0C1H3.
PROiPR:P0C1H3.

Gene expression databases

BgeeiENSGALG00000027174.

Family and domain databases

InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PRINTSiPR00621. HISTONEH2B.
SMARTiView protein in SMART
SM00427. H2B. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00357. HISTONE_H2B. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiH2B1_CHICK
AccessioniPrimary (citable) accession number: P0C1H3
Secondary accession number(s): P02279, Q92067
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.