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Protein

Histone H2B 1/2/3/4/6

Gene

H2B-I

more
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.1 Publication
Has broad-spectrum antibacterial activity. May be important in the antimicrobial defenses of chick reproductive system during follicle development in the ovary and egg formation in the oviduct.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-GGA-3214815. HDACs deacetylate histones.
R-GGA-3214847. HATs acetylate histones.
R-GGA-5689880. Ub-specific processing proteases.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2B 1/2/3/4/6
Alternative name(s):
H2B I
H2B II
H2B III
H2B IV
H2B VI
Gene namesi
Name:H2B-I
AND
Name:H2B-II
AND
Name:H2B-III
AND
Name:H2B-IV
AND
Name:H2B-VI
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000718462 – 126Histone H2B 1/2/3/4/6Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6N6-acetyllysine1 Publication1
Modified residuei13N6-acetyllysine1 Publication1
Modified residuei15Phosphoserine1 Publication1
Modified residuei16N6-acetyllysine1 Publication1
Modified residuei21N6-acetyllysine1 Publication1
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

Monoubiquitination of Lys-121 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.By similarity
Phosphorylated on Ser-15 during apoptosis; which facilitates apoptotic chromatin condensation.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP0C1H3.
PRIDEiP0C1H3.

PTM databases

iPTMnetiP0C1H3.

Expressioni

Gene expression databases

BgeeiENSGALG00000027174.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Protein-protein interaction databases

BioGridi679231. 3 interactors.
IntActiP0C1H3. 1 interactor.
STRINGi9031.ENSGALP00000037300.

Structurei

Secondary structure

1126
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi39 – 49Combined sources11
Helixi57 – 84Combined sources28
Beta strandi88 – 90Combined sources3
Helixi92 – 102Combined sources11
Helixi105 – 124Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AROX-ray2.10B/F1-126[»]
ProteinModelPortaliP0C1H3.
SMRiP0C1H3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C1H3.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00760000118976.
HOGENOMiHOG000231213.
HOVERGENiHBG007774.
InParanoidiP0C1H3.
KOiK11252.
OMAiNKSHEMP.
OrthoDBiEOG091G0XGD.
PhylomeDBiP0C1H3.
TreeFamiTF300212.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C1H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEPAKSAPA PKKGSKKAVT KTQKKGDKKR KKSRKESYSI YVYKVLKQVH
60 70 80 90 100
PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR
110 120
LLLPGELAKH AVSEGTKAVT KYTSSK
Length:126
Mass (Da):13,922
Last modified:January 23, 2007 - v2
Checksum:i908F039A02A3400D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14G → A in CAA28745 (PubMed:3822819).Curated1
Sequence conflicti36E → A in CAA28747 (PubMed:3822819).Curated1
Sequence conflicti62I → S AA sequence (PubMed:7074112).Curated1
Sequence conflicti123T → I in CAA28751 (PubMed:3822819).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00415 Genomic DNA. Translation: CAA23706.1.
X05094 Genomic DNA. Translation: CAA28745.1.
X05095 Genomic DNA. Translation: CAA28746.1.
X05096 Genomic DNA. Translation: CAA28747.1.
X05097 Genomic DNA. Translation: CAA28748.1.
X05098 Genomic DNA. Translation: CAA28749.1.
X05100 Genomic DNA. Translation: CAA28751.1.
X57263 Genomic DNA. Translation: CAA40537.1.
X07763 Genomic DNA. Translation: CAA30590.1.
X07766 Genomic DNA. Translation: CAA30596.1.
PIRiB26399.
S14510. HSCH22.
RefSeqiNP_001073188.1. NM_001079720.1.
XP_001232985.1. XM_001232984.3.
XP_001233227.1. XM_001233226.4.
XP_001233337.1. XM_001233336.4.
UniGeneiGga.39843.
Gga.40038.

Genome annotation databases

EnsembliENSGALT00000021778; ENSGALP00000021742; ENSGALG00000042263.
ENSGALT00000042841; ENSGALP00000042437; ENSGALG00000027594.
ENSGALT00000043224; ENSGALP00000042501; ENSGALG00000027571.
ENSGALT00000052037; ENSGALP00000053434; ENSGALG00000039722.
ENSGALT00000054609; ENSGALP00000054120; ENSGALG00000037934.
GeneIDi417956.
769973.
770188.
770267.
KEGGigga:417956.
gga:769973.
gga:770188.
gga:770267.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00415 Genomic DNA. Translation: CAA23706.1.
X05094 Genomic DNA. Translation: CAA28745.1.
X05095 Genomic DNA. Translation: CAA28746.1.
X05096 Genomic DNA. Translation: CAA28747.1.
X05097 Genomic DNA. Translation: CAA28748.1.
X05098 Genomic DNA. Translation: CAA28749.1.
X05100 Genomic DNA. Translation: CAA28751.1.
X57263 Genomic DNA. Translation: CAA40537.1.
X07763 Genomic DNA. Translation: CAA30590.1.
X07766 Genomic DNA. Translation: CAA30596.1.
PIRiB26399.
S14510. HSCH22.
RefSeqiNP_001073188.1. NM_001079720.1.
XP_001232985.1. XM_001232984.3.
XP_001233227.1. XM_001233226.4.
XP_001233337.1. XM_001233336.4.
UniGeneiGga.39843.
Gga.40038.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AROX-ray2.10B/F1-126[»]
ProteinModelPortaliP0C1H3.
SMRiP0C1H3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi679231. 3 interactors.
IntActiP0C1H3. 1 interactor.
STRINGi9031.ENSGALP00000037300.

PTM databases

iPTMnetiP0C1H3.

Proteomic databases

PaxDbiP0C1H3.
PRIDEiP0C1H3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000021778; ENSGALP00000021742; ENSGALG00000042263.
ENSGALT00000042841; ENSGALP00000042437; ENSGALG00000027594.
ENSGALT00000043224; ENSGALP00000042501; ENSGALG00000027571.
ENSGALT00000052037; ENSGALP00000053434; ENSGALG00000039722.
ENSGALT00000054609; ENSGALP00000054120; ENSGALG00000037934.
GeneIDi417956.
769973.
770188.
770267.
KEGGigga:417956.
gga:769973.
gga:770188.
gga:770267.

Organism-specific databases

CTDi417956.
770188.
770267.
8343.

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00760000118976.
HOGENOMiHOG000231213.
HOVERGENiHBG007774.
InParanoidiP0C1H3.
KOiK11252.
OMAiNKSHEMP.
OrthoDBiEOG091G0XGD.
PhylomeDBiP0C1H3.
TreeFamiTF300212.

Enzyme and pathway databases

ReactomeiR-GGA-3214815. HDACs deacetylate histones.
R-GGA-3214847. HATs acetylate histones.
R-GGA-5689880. Ub-specific processing proteases.

Miscellaneous databases

EvolutionaryTraceiP0C1H3.
PROiP0C1H3.

Gene expression databases

BgeeiENSGALG00000027174.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH2B1_CHICK
AccessioniPrimary (citable) accession number: P0C1H3
Secondary accession number(s): P02279, Q92067
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.