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Protein

Transcription factor SOX-11

Gene

Sox11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi49 – 11769HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-11
Gene namesi
Name:Sox11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi69351. Sox11.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationBy similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Transcription factor SOX-11PRO_0000244267Add
BLAST

Proteomic databases

PaxDbiP0C1G9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000030034.
GenevisibleiP0C1G9. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040127.

Structurei

3D structure databases

ProteinModelPortaliP0C1G9.
SMRiP0C1G9. Positions 49-125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi188 – 21427Asp/Glu-rich (highly acidic)Add
BLAST
Compositional biasi297 – 30812Poly-SerAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0527. Eukaryota.
ENOG410XT0K. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231874.
HOVERGENiHBG005040.
InParanoidiP0C1G9.
KOiK09268.
OMAiTVKCVFM.
OrthoDBiEOG091G0F15.
PhylomeDBiP0C1G9.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR029551. SOX-11.
[Graphical view]
PANTHERiPTHR10270:SF113. PTHR10270:SF113. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C1G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQQAESSEA ESNLPRDALD TEEGEFMACS PVALDESDPD WCKTASGHIK
60 70 80 90 100
RPMNAFMVWS KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR
110 120 130 140 150
EAERLRLKHM ADYPDYKYRP RKKPKTDPAA KPSAGQSPDK SAAGAKAAKG
160 170 180 190 200
PGKKCAKLKA PAGKAGAGKA AQPGDCGAGK AAKCVFLDDD DEEDDEDDEL
210 220 230 240 250
QLRPKPDADD DDDEPAHSHL LPPPAQQQPP QLLRRYSVAK VPASPTLSSA
260 270 280 290 300
AESPEGASLY DEVRAGGRLY YSFKNITKQQ PPPAPPALSP ASSRCVSTSS
310 320 330 340 350
SSGSSSGSGA EDADDLMFDL SLNFSQGAHS ACEQPLGAGA AGNLSLSLVD
360 370 380 390
KDLDSFSEGS LGSHFEFPDY CTPELSEMIA GDWLEANFSD LVFTY
Length:395
Mass (Da):42,599
Last modified:June 27, 2006 - v1
Checksum:i0AE6CBF6CE991D58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ004858 mRNA. Translation: CAA06166.1.
RefSeqiNP_445801.1. NM_053349.1.
UniGeneiRn.162854.

Genome annotation databases

EnsembliENSRNOT00000045963; ENSRNOP00000040127; ENSRNOG00000030034.
GeneIDi84046.
KEGGirno:84046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ004858 mRNA. Translation: CAA06166.1.
RefSeqiNP_445801.1. NM_053349.1.
UniGeneiRn.162854.

3D structure databases

ProteinModelPortaliP0C1G9.
SMRiP0C1G9. Positions 49-125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040127.

Proteomic databases

PaxDbiP0C1G9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045963; ENSRNOP00000040127; ENSRNOG00000030034.
GeneIDi84046.
KEGGirno:84046.

Organism-specific databases

CTDi6664.
RGDi69351. Sox11.

Phylogenomic databases

eggNOGiKOG0527. Eukaryota.
ENOG410XT0K. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231874.
HOVERGENiHBG005040.
InParanoidiP0C1G9.
KOiK09268.
OMAiTVKCVFM.
OrthoDBiEOG091G0F15.
PhylomeDBiP0C1G9.
TreeFamiTF351735.

Miscellaneous databases

PROiP0C1G9.

Gene expression databases

BgeeiENSRNOG00000030034.
GenevisibleiP0C1G9. RN.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR029551. SOX-11.
[Graphical view]
PANTHERiPTHR10270:SF113. PTHR10270:SF113. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSOX11_RAT
AccessioniPrimary (citable) accession number: P0C1G9
Secondary accession number(s): O35178, O89036, Q04889
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.