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P0C1G8

- PSA4A_ORYSJ

UniProt

P0C1G8 - PSA4A_ORYSJ

Protein

Proteasome subunit alpha type-4-1

Gene

PAC1

more
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Enzyme and pathway databases

    ReactomeiREACT_205610. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_205939. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_207219. APC/C:Cdc20 mediated degradation of Securin.
    REACT_212204. Separation of Sister Chromatids.
    REACT_214064. ER-Phagosome pathway.
    REACT_219834. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_223172. Antigen processing: Ubiquitination & Proteasome degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alpha type-4-1 (EC:3.4.25.1)
    Alternative name(s):
    20S proteasome alpha subunit C
    20S proteasome subunit alpha-3
    Gene namesi
    Name:PAC1
    Ordered Locus Names:Os06g0176000, LOC_Os06g07878
    ORF Names:OsJ_019497, P0015E04.21
    AND
    Ordered Locus Names:Os06g0177100, LOC_Os06g07978
    ORF Names:P0015E04.34
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 6

    Organism-specific databases

    GrameneiP0C1G8.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. proteasome core complex, alpha-subunit complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250Proteasome subunit alpha type-4-1PRO_0000124112Add
    BLAST

    Proteomic databases

    PRIDEiP0C1G8.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP0C1G8.
    SMRiP0C1G8. Positions 2-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    KOiK02728.
    OMAiKQEYKDD.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view]
    SMARTiSM00948. Proteasome_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C1G8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRRYDSRTT IFSPEGRLYQ VEYAMEAIGN AGSALGVLAA DGVVLVGEKK    50
    VTSKLLQTSR SAEKMYKIDS HLACAVAGIM SDANILLNTA RLHAQRYALS 100
    YQEPIPVEQL VQSLCDTKQG YTQFGGLRPF GVSFLFAGWD KHHGFQLYMS 150
    DPSGNYSGWK AAAVGANSQA AQSMLKQDYR DGMTREEAVA LALKVLSKTM 200
    DSTSLTAEKL ELAEVFLQPG TGEVQYQVCS PEAMGKLLAK AGLSQPAPEA 250
    Length:250
    Mass (Da):27,044
    Last modified:June 27, 2006 - v1
    Checksum:i00FDAD801A97ABD4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026560 mRNA. Translation: BAA96831.1.
    AP002069 Genomic DNA. Translation: BAA95822.1.
    AP002069 Genomic DNA. Translation: BAA95832.1.
    AP008212 Genomic DNA. Translation: BAF18867.1.
    CM000143 Genomic DNA. Translation: EAZ36014.1.
    RefSeqiNP_001056953.1. NM_001063488.2.
    UniGeneiOs.88355.

    Genome annotation databases

    EnsemblPlantsiOS06T0176000-01; OS06T0176000-01; OS06G0176000.
    OS06T0177100-01; OS06T0177100-01; OS06G0177100.
    GeneIDi4340285.
    KEGGiosa:4340285.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026560 mRNA. Translation: BAA96831.1 .
    AP002069 Genomic DNA. Translation: BAA95822.1 .
    AP002069 Genomic DNA. Translation: BAA95832.1 .
    AP008212 Genomic DNA. Translation: BAF18867.1 .
    CM000143 Genomic DNA. Translation: EAZ36014.1 .
    RefSeqi NP_001056953.1. NM_001063488.2.
    UniGenei Os.88355.

    3D structure databases

    ProteinModelPortali P0C1G8.
    SMRi P0C1G8. Positions 2-220.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P0C1G8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS06T0176000-01 ; OS06T0176000-01 ; OS06G0176000 .
    OS06T0177100-01 ; OS06T0177100-01 ; OS06G0177100 .
    GeneIDi 4340285.
    KEGGi osa:4340285.

    Organism-specific databases

    Gramenei P0C1G8.

    Phylogenomic databases

    eggNOGi COG0638.
    KOi K02728.
    OMAi KQEYKDD.

    Enzyme and pathway databases

    Reactomei REACT_205610. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_205939. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_207219. APC/C:Cdc20 mediated degradation of Securin.
    REACT_212204. Separation of Sister Chromatids.
    REACT_214064. ER-Phagosome pathway.
    REACT_219834. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_223172. Antigen processing: Ubiquitination & Proteasome degradation.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SMARTi SM00948. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structural features of the 20S proteasome subunits of rice (Oryza sativa)."
      Sassa H., Oguchi S., Inoue T., Hirano H.
      Gene 250:61-66(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    4. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiPSA4A_ORYSJ
    AccessioniPrimary (citable) accession number: P0C1G8
    Secondary accession number(s): Q0DE56, Q9LE92, Q9XIZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3