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P0C1G8

- PSA4A_ORYSJ

UniProt

P0C1G8 - PSA4A_ORYSJ

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Protein
Proteasome subunit alpha type-4-1
Gene
PAC1, Os06g0176000, LOC_Os06g07878, OsJ_019497, P0015E04.21
Os06g0177100, LOC_Os06g07978, P0015E04.34
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_205610. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_205939. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_207219. APC/C:Cdc20 mediated degradation of Securin.
REACT_212204. Separation of Sister Chromatids.
REACT_214064. ER-Phagosome pathway.
REACT_219834. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_223172. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
Proteasome subunit alpha type-4-1 (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit C
20S proteasome subunit alpha-3
Gene namesi
Name:PAC1
Ordered Locus Names:Os06g0176000, LOC_Os06g07878
ORF Names:OsJ_019497, P0015E04.21
AND
Ordered Locus Names:Os06g0177100, LOC_Os06g07978
ORF Names:P0015E04.34
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 6
GrameneiP0C1G8.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. proteasome core complex, alpha-subunit complex Source: InterPro

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Proteasome subunit alpha type-4-1
PRO_0000124112Add
BLAST

Proteomic databases

PRIDEiP0C1G8.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Structurei

3D structure databases

ProteinModelPortaliP0C1G8.
SMRiP0C1G8. Positions 2-220.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.

Phylogenomic databases

eggNOGiCOG0638.
KOiK02728.
OMAiKQEYKDD.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C1G8-1 [UniParc]FASTAAdd to Basket

« Hide

MSRRYDSRTT IFSPEGRLYQ VEYAMEAIGN AGSALGVLAA DGVVLVGEKK    50
VTSKLLQTSR SAEKMYKIDS HLACAVAGIM SDANILLNTA RLHAQRYALS 100
YQEPIPVEQL VQSLCDTKQG YTQFGGLRPF GVSFLFAGWD KHHGFQLYMS 150
DPSGNYSGWK AAAVGANSQA AQSMLKQDYR DGMTREEAVA LALKVLSKTM 200
DSTSLTAEKL ELAEVFLQPG TGEVQYQVCS PEAMGKLLAK AGLSQPAPEA 250
Length:250
Mass (Da):27,044
Last modified:June 27, 2006 - v1
Checksum:i00FDAD801A97ABD4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026560 mRNA. Translation: BAA96831.1.
AP002069 Genomic DNA. Translation: BAA95822.1.
AP002069 Genomic DNA. Translation: BAA95832.1.
AP008212 Genomic DNA. Translation: BAF18867.1.
CM000143 Genomic DNA. Translation: EAZ36014.1.
RefSeqiNP_001056953.1. NM_001063488.2.
UniGeneiOs.88355.

Genome annotation databases

EnsemblPlantsiOS06T0176000-01; OS06T0176000-01; OS06G0176000.
OS06T0177100-01; OS06T0177100-01; OS06G0177100.
GeneIDi4340285.
KEGGiosa:4340285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026560 mRNA. Translation: BAA96831.1 .
AP002069 Genomic DNA. Translation: BAA95822.1 .
AP002069 Genomic DNA. Translation: BAA95832.1 .
AP008212 Genomic DNA. Translation: BAF18867.1 .
CM000143 Genomic DNA. Translation: EAZ36014.1 .
RefSeqi NP_001056953.1. NM_001063488.2.
UniGenei Os.88355.

3D structure databases

ProteinModelPortali P0C1G8.
SMRi P0C1G8. Positions 2-220.
ModBasei Search...

Proteomic databases

PRIDEi P0C1G8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS06T0176000-01 ; OS06T0176000-01 ; OS06G0176000 .
OS06T0177100-01 ; OS06T0177100-01 ; OS06G0177100 .
GeneIDi 4340285.
KEGGi osa:4340285.

Organism-specific databases

Gramenei P0C1G8.

Phylogenomic databases

eggNOGi COG0638.
KOi K02728.
OMAi KQEYKDD.

Enzyme and pathway databases

Reactomei REACT_205610. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_205939. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_207219. APC/C:Cdc20 mediated degradation of Securin.
REACT_212204. Separation of Sister Chromatids.
REACT_214064. ER-Phagosome pathway.
REACT_219834. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_223172. Antigen processing: Ubiquitination & Proteasome degradation.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view ]
SMARTi SM00948. Proteasome_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structural features of the 20S proteasome subunits of rice (Oryza sativa)."
    Sassa H., Oguchi S., Inoue T., Hirano H.
    Gene 250:61-66(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiPSA4A_ORYSJ
AccessioniPrimary (citable) accession number: P0C1G8
Secondary accession number(s): Q0DE56, Q9LE92, Q9XIZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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