P0C1G5 (MDH_KLEPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Malate dehydrogenase
EC=1.1.1.37

Gene names

Name:

mdh

Organism

Klebsiella pneumoniae subsp. rhinoscleromatis

Taxonomic identifier

39831 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella › Klebsiella pneumoniae

Protein attributes

Sequence length	114 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_01516
Catalytic activity	(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_01516
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the LDH/MDH superfamily. MDH type 1 family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	L-malate dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›114	›114	Malate dehydrogenase HAMAP-Rule MF_01516		PRO_0000240201
Regions
	Nucleotide binding	87 – 89	3	NAD By similarity
Sites
	Binding site	4	1	NAD By similarity
	Binding site	51	1	Substrate By similarity
	Binding site	57	1	Substrate By similarity
	Binding site	64	1	NAD By similarity
	Binding site	89	1	Substrate By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	114	1

Sequences

	Sequence		Length	Mass (Da)
	P0C1G5 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: D63AEB7FD35062AE	FASTA	114	11,913
	10 20 30 40 50 60 SLYDIAPVTP GVAVDLSHIP TDVKIKGFSG EDATPALEGA DVVLISAGVA RKPGMDRSDL 70 80 90 100 110 FNVNAGIVKN LVQQIAKTRP QACIGIITNP VNTTVAIAAE VLKKAGVYDK NKLF

References

[1]

"Diversity and evolution of the class A chromosomal beta-lactamase gene in Klebsiella pneumoniae." Haeggman S., Loefdahl S., Paauw A., Verhoef J., Brisse S. Antimicrob. Agents Chemother. 48:2400-2408(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 13884 / JCM 1664 / LMG 3184 / NCTC 5046 / R-70.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ635391 Genomic DNA. Translation: CAG25802.1.
3D structure databases
ProteinModelPortal	P0C1G5.
SMR	P0C1G5. Positions 1-114.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_01516. Malate_dehydrog_1.
InterPro	IPR001557. L-lactate/malate_DH. IPR001236. Lactate/malate_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11540. PTHR11540. 1 hit.
Pfam	PF00056. Ldh_1_N. 1 hit. [Graphical view]
PROSITE	PS00068. MDH. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MDH_KLEPR

Accession

Primary (citable) accession number: P0C1G5
Secondary accession number(s): P80535

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	June 13, 2006
Last modified:	March 6, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program