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P0C1G5

- MDH_KLEPR

UniProt

P0C1G5 - MDH_KLEPR

Protein

Malate dehydrogenase

Gene

mdh

Organism
Klebsiella pneumoniae subsp. rhinoscleromatis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei4 – 41NADBy similarity
    Binding sitei51 – 511SubstratePROSITE-ProRule annotation
    Binding sitei57 – 571SubstratePROSITE-ProRule annotation
    Binding sitei64 – 641NADBy similarity
    Binding sitei89 – 891SubstratePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi87 – 893NADBy similarity

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase (EC:1.1.1.37)
    Gene namesi
    Name:mdh
    OrganismiKlebsiella pneumoniae subsp. rhinoscleromatis
    Taxonomic identifieri39831 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›114›114Malate dehydrogenasePRO_0000240201Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP0C1G5.
    SMRiP0C1G5. Positions 1-114.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR001236. Lactate/malate_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF00056. Ldh_1_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P0C1G5-1 [UniParc]FASTAAdd to Basket

    « Hide

    SLYDIAPVTP GVAVDLSHIP TDVKIKGFSG EDATPALEGA DVVLISAGVA    50
    RKPGMDRSDL FNVNAGIVKN LVQQIAKTRP QACIGIITNP VNTTVAIAAE 100
    VLKKAGVYDK NKLF 114
    Length:114
    Mass (Da):11,913
    Last modified:June 13, 2006 - v1
    Checksum:iD63AEB7FD35062AE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei114 – 1141

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ635391 Genomic DNA. Translation: CAG25802.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ635391 Genomic DNA. Translation: CAG25802.1 .

    3D structure databases

    ProteinModelPortali P0C1G5.
    SMRi P0C1G5. Positions 1-114.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR001236. Lactate/malate_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Diversity and evolution of the class A chromosomal beta-lactamase gene in Klebsiella pneumoniae."
      Haeggman S., Loefdahl S., Paauw A., Verhoef J., Brisse S.
      Antimicrob. Agents Chemother. 48:2400-2408(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 13884 / JCM 1664 / LMG 3184 / NCTC 5046 / R-70.

    Entry informationi

    Entry nameiMDH_KLEPR
    AccessioniPrimary (citable) accession number: P0C1G5
    Secondary accession number(s): P80535
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3