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Protein

Malate dehydrogenase

Gene

mdh

Organism
Klebsiella pneumoniae subsp. rhinoscleromatis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei4 – 41NADBy similarity
Binding sitei51 – 511SubstratePROSITE-ProRule annotation
Binding sitei57 – 571SubstratePROSITE-ProRule annotation
Binding sitei64 – 641NADBy similarity
Binding sitei89 – 891SubstratePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi87 – 893NADBy similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
OrganismiKlebsiella pneumoniae subsp. rhinoscleromatis
Taxonomic identifieri39831 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›114›114Malate dehydrogenasePRO_0000240201Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0C1G5.
SMRiP0C1G5. Positions 1-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR001236. Lactate/malate_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF00056. Ldh_1_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P0C1G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SLYDIAPVTP GVAVDLSHIP TDVKIKGFSG EDATPALEGA DVVLISAGVA
60 70 80 90 100
RKPGMDRSDL FNVNAGIVKN LVQQIAKTRP QACIGIITNP VNTTVAIAAE
110
VLKKAGVYDK NKLF
Length:114
Mass (Da):11,913
Last modified:June 13, 2006 - v1
Checksum:iD63AEB7FD35062AE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei114 – 1141

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ635391 Genomic DNA. Translation: CAG25802.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ635391 Genomic DNA. Translation: CAG25802.1.

3D structure databases

ProteinModelPortaliP0C1G5.
SMRiP0C1G5. Positions 1-114.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR001236. Lactate/malate_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF00056. Ldh_1_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Diversity and evolution of the class A chromosomal beta-lactamase gene in Klebsiella pneumoniae."
    Haeggman S., Loefdahl S., Paauw A., Verhoef J., Brisse S.
    Antimicrob. Agents Chemother. 48:2400-2408(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13884 / JCM 1664 / LMG 3184 / NCTC 5046 / R-70.

Entry informationi

Entry nameiMDH_KLEPR
AccessioniPrimary (citable) accession number: P0C1G5
Secondary accession number(s): P80535
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: October 1, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.