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P0C1G5

- MDH_KLEPR

UniProt

P0C1G5 - MDH_KLEPR

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Protein

Malate dehydrogenase

Gene
mdh
Organism
Klebsiella pneumoniae subsp. rhinoscleromatis
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei4 – 41NAD By similarity
Binding sitei51 – 511Substrate By similarity
Binding sitei57 – 571Substrate By similarity
Binding sitei64 – 641NAD By similarity
Binding sitei89 – 891Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi87 – 893NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
OrganismiKlebsiella pneumoniae subsp. rhinoscleromatis
Taxonomic identifieri39831 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›114›114Malate dehydrogenasePRO_0000240201Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP0C1G5.
SMRiP0C1G5. Positions 1-114.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR001236. Lactate/malate_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF00056. Ldh_1_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P0C1G5-1 [UniParc]FASTAAdd to Basket

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SLYDIAPVTP GVAVDLSHIP TDVKIKGFSG EDATPALEGA DVVLISAGVA    50
RKPGMDRSDL FNVNAGIVKN LVQQIAKTRP QACIGIITNP VNTTVAIAAE 100
VLKKAGVYDK NKLF 114
Length:114
Mass (Da):11,913
Last modified:June 13, 2006 - v1
Checksum:iD63AEB7FD35062AE
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei114 – 1141

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ635391 Genomic DNA. Translation: CAG25802.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ635391 Genomic DNA. Translation: CAG25802.1 .

3D structure databases

ProteinModelPortali P0C1G5.
SMRi P0C1G5. Positions 1-114.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR001236. Lactate/malate_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Diversity and evolution of the class A chromosomal beta-lactamase gene in Klebsiella pneumoniae."
    Haeggman S., Loefdahl S., Paauw A., Verhoef J., Brisse S.
    Antimicrob. Agents Chemother. 48:2400-2408(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13884 / JCM 1664 / LMG 3184 / NCTC 5046 / R-70.

Entry informationi

Entry nameiMDH_KLEPR
AccessioniPrimary (citable) accession number: P0C1G5
Secondary accession number(s): P80535
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: February 19, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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