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P0C1G0 (DGK2_LACAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyguanosine kinase

Short name=DGK
Short name=DGUO kinase
EC=2.7.1.113
Alternative name(s):
Deoxynucleoside kinase complex I F-component
Gene names
Ordered Locus Names:LBA1950
OrganismLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) [Complete proteome] [HAMAP]
Taxonomic identifier272621 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

DGK/DAK plays an essential role in generating the deoxyribonucleotide precursors, dGTP and dATP, for DNA metabolism By similarity.

Catalytic activity

ATP + deoxyguanosine = ADP + dGMP.

Subunit structure

Heterodimer of a deoxyadenosine (DAK) and a deoxyguanosine kinase (DGK) By similarity.

Sequence similarities

Belongs to the DCK/DGK family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 228227Deoxyguanosine kinase
PRO_0000175096

Regions

Nucleotide binding8 – 169ATP By similarity

Sites

Active site781Proton acceptor Potential
Binding site321Substrate By similarity
Binding site441Substrate By similarity
Binding site551Substrate By similarity
Binding site791Substrate By similarity
Binding site841Substrate By similarity
Binding site1491Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C1G0 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 6AD4F19B283B6C37

FASTA22826,691
        10         20         30         40         50         60 
MTVIVLSGPI GAGKSSLTGI LSKYLGTKPF YESVDDNPVL PLFYADPKKY AFLLQVYFLN 

        70         80         90        100        110        120 
TRFHSIKNAL TQDNNVLDRS IYEDALFFQM NADIGRATSE EVDTYYELLH NMMGELDRMP 

       130        140        150        160        170        180 
KKNPDLLVHI NVSYDTMIKR IKKRGRPYEQ LSYDSTLEDY YKRLLRYYKP WYEKYDYSPK 

       190        200        210        220 
MVIDGDKYDF MSSEADREIV LDQIVDKLKE VGKLPMDWDK STDIQIEA 

« Hide

References

[1]"Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM."
Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L., McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S., Hamrick A., Cano R., Klaenhammer T.R.
Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000033 Genomic DNA. Translation: AAV43745.1.
RefSeqYP_194776.1. NC_006814.3.

3D structure databases

ProteinModelPortalP0C1G0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272621.LBA1950.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV43745; AAV43745; LBA1950.
GeneID3251915.
KEGGlac:LBA1950.
PATRIC22198905. VBILacAci7974_1854.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1428.
HOGENOMHOG000030092.
OMAFERPQDN.
OrthoDBEOG628F9B.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR002624. Deoxynucleoside_kinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR10513. PTHR10513. 1 hit.
PfamPF01712. dNK. 1 hit.
[Graphical view]
PIRSFPIRSF000705. DNK. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDGK2_LACAC
AccessionPrimary (citable) accession number: P0C1G0
Secondary accession number(s): Q59484, Q5FHS9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families