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P0C1G0

- DGK2_LACAC

UniProt

P0C1G0 - DGK2_LACAC

Protein

Deoxyguanosine kinase

Gene

LBA1950

Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    DGK/DAK plays an essential role in generating the deoxyribonucleotide precursors, dGTP and dATP, for DNA metabolism.By similarity

    Catalytic activityi

    ATP + deoxyguanosine = ADP + dGMP.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei32 – 321SubstrateBy similarity
    Binding sitei44 – 441SubstrateBy similarity
    Binding sitei55 – 551SubstrateBy similarity
    Active sitei78 – 781Proton acceptorSequence Analysis
    Binding sitei79 – 791SubstrateBy similarity
    Binding sitei84 – 841SubstrateBy similarity
    Binding sitei149 – 1491SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 169ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. deoxyguanosine kinase activity Source: UniProtKB-EC
    3. phosphotransferase activity, alcohol group as acceptor Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyguanosine kinase (EC:2.7.1.113)
    Short name:
    DGK
    Short name:
    DGUO kinase
    Alternative name(s):
    Deoxynucleoside kinase complex I F-component
    Gene namesi
    Ordered Locus Names:LBA1950
    OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
    Taxonomic identifieri272621 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000006381: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 228227Deoxyguanosine kinasePRO_0000175096Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a deoxyadenosine (DAK) and a deoxyguanosine kinase (DGK).By similarity

    Protein-protein interaction databases

    STRINGi272621.LBA1950.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C1G0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DCK/DGK family.Curated

    Phylogenomic databases

    eggNOGiCOG1428.
    HOGENOMiHOG000030092.
    OMAiFERPQDN.
    OrthoDBiEOG628F9B.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR002624. DNK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10513. PTHR10513. 1 hit.
    PfamiPF01712. dNK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000705. DNK. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C1G0-1 [UniParc]FASTAAdd to Basket

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    MTVIVLSGPI GAGKSSLTGI LSKYLGTKPF YESVDDNPVL PLFYADPKKY    50
    AFLLQVYFLN TRFHSIKNAL TQDNNVLDRS IYEDALFFQM NADIGRATSE 100
    EVDTYYELLH NMMGELDRMP KKNPDLLVHI NVSYDTMIKR IKKRGRPYEQ 150
    LSYDSTLEDY YKRLLRYYKP WYEKYDYSPK MVIDGDKYDF MSSEADREIV 200
    LDQIVDKLKE VGKLPMDWDK STDIQIEA 228
    Length:228
    Mass (Da):26,691
    Last modified:January 23, 2007 - v2
    Checksum:i6AD4F19B283B6C37
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000033 Genomic DNA. Translation: AAV43745.1.
    RefSeqiYP_194776.1. NC_006814.3.

    Genome annotation databases

    EnsemblBacteriaiAAV43745; AAV43745; LBA1950.
    GeneIDi3251915.
    KEGGilac:LBA1950.
    PATRICi22198905. VBILacAci7974_1854.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000033 Genomic DNA. Translation: AAV43745.1 .
    RefSeqi YP_194776.1. NC_006814.3.

    3D structure databases

    ProteinModelPortali P0C1G0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272621.LBA1950.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV43745 ; AAV43745 ; LBA1950 .
    GeneIDi 3251915.
    KEGGi lac:LBA1950.
    PATRICi 22198905. VBILacAci7974_1854.

    Phylogenomic databases

    eggNOGi COG1428.
    HOGENOMi HOG000030092.
    OMAi FERPQDN.
    OrthoDBi EOG628F9B.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR002624. DNK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10513. PTHR10513. 1 hit.
    Pfami PF01712. dNK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000705. DNK. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700396 / NCK56 / N2 / NCFM.

    Entry informationi

    Entry nameiDGK2_LACAC
    AccessioniPrimary (citable) accession number: P0C1G0
    Secondary accession number(s): Q59484, Q5FHS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3