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P0C1G0

- DGK2_LACAC

UniProt

P0C1G0 - DGK2_LACAC

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Protein

Deoxyguanosine kinase

Gene
LBA1950
Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DGK/DAK plays an essential role in generating the deoxyribonucleotide precursors, dGTP and dATP, for DNA metabolism By similarity.

Catalytic activityi

ATP + deoxyguanosine = ADP + dGMP.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321Substrate By similarity
Binding sitei44 – 441Substrate By similarity
Binding sitei55 – 551Substrate By similarity
Active sitei78 – 781Proton acceptor Reviewed prediction
Binding sitei79 – 791Substrate By similarity
Binding sitei84 – 841Substrate By similarity
Binding sitei149 – 1491Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. deoxyguanosine kinase activity Source: UniProtKB-EC
  3. phosphotransferase activity, alcohol group as acceptor Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyguanosine kinase (EC:2.7.1.113)
Short name:
DGK
Short name:
DGUO kinase
Alternative name(s):
Deoxynucleoside kinase complex I F-component
Gene namesi
Ordered Locus Names:LBA1950
OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Taxonomic identifieri272621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006381: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 228227Deoxyguanosine kinasePRO_0000175096Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a deoxyadenosine (DAK) and a deoxyguanosine kinase (DGK) By similarity.

Protein-protein interaction databases

STRINGi272621.LBA1950.

Structurei

3D structure databases

ProteinModelPortaliP0C1G0.

Family & Domainsi

Sequence similaritiesi

Belongs to the DCK/DGK family.

Phylogenomic databases

eggNOGiCOG1428.
HOGENOMiHOG000030092.
OMAiFERPQDN.
OrthoDBiEOG628F9B.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10513. PTHR10513. 1 hit.
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000705. DNK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C1G0-1 [UniParc]FASTAAdd to Basket

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MTVIVLSGPI GAGKSSLTGI LSKYLGTKPF YESVDDNPVL PLFYADPKKY    50
AFLLQVYFLN TRFHSIKNAL TQDNNVLDRS IYEDALFFQM NADIGRATSE 100
EVDTYYELLH NMMGELDRMP KKNPDLLVHI NVSYDTMIKR IKKRGRPYEQ 150
LSYDSTLEDY YKRLLRYYKP WYEKYDYSPK MVIDGDKYDF MSSEADREIV 200
LDQIVDKLKE VGKLPMDWDK STDIQIEA 228
Length:228
Mass (Da):26,691
Last modified:January 23, 2007 - v2
Checksum:i6AD4F19B283B6C37
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000033 Genomic DNA. Translation: AAV43745.1.
RefSeqiYP_194776.1. NC_006814.3.

Genome annotation databases

EnsemblBacteriaiAAV43745; AAV43745; LBA1950.
GeneIDi3251915.
KEGGilac:LBA1950.
PATRICi22198905. VBILacAci7974_1854.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000033 Genomic DNA. Translation: AAV43745.1 .
RefSeqi YP_194776.1. NC_006814.3.

3D structure databases

ProteinModelPortali P0C1G0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272621.LBA1950.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV43745 ; AAV43745 ; LBA1950 .
GeneIDi 3251915.
KEGGi lac:LBA1950.
PATRICi 22198905. VBILacAci7974_1854.

Phylogenomic databases

eggNOGi COG1428.
HOGENOMi HOG000030092.
OMAi FERPQDN.
OrthoDBi EOG628F9B.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10513. PTHR10513. 1 hit.
Pfami PF01712. dNK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000705. DNK. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Entry informationi

Entry nameiDGK2_LACAC
AccessioniPrimary (citable) accession number: P0C1G0
Secondary accession number(s): Q59484, Q5FHS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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