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P0C1G0

- DGK2_LACAC

UniProt

P0C1G0 - DGK2_LACAC

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Protein

Deoxyguanosine kinase

Gene

LBA1950

Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DGK/DAK plays an essential role in generating the deoxyribonucleotide precursors, dGTP and dATP, for DNA metabolism.By similarity

Catalytic activityi

ATP + deoxyguanosine = ADP + dGMP.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321SubstrateBy similarity
Binding sitei44 – 441SubstrateBy similarity
Binding sitei55 – 551SubstrateBy similarity
Active sitei78 – 781Proton acceptorSequence Analysis
Binding sitei79 – 791SubstrateBy similarity
Binding sitei84 – 841SubstrateBy similarity
Binding sitei149 – 1491SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. deoxyguanosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyguanosine kinase (EC:2.7.1.113)
Short name:
DGK
Short name:
DGUO kinase
Alternative name(s):
Deoxynucleoside kinase complex I F-component
Gene namesi
Ordered Locus Names:LBA1950
OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Taxonomic identifieri272621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006381: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 228227Deoxyguanosine kinasePRO_0000175096Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a deoxyadenosine (DAK) and a deoxyguanosine kinase (DGK).By similarity

Protein-protein interaction databases

STRINGi272621.LBA1950.

Structurei

3D structure databases

ProteinModelPortaliP0C1G0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DCK/DGK family.Curated

Phylogenomic databases

eggNOGiCOG1428.
HOGENOMiHOG000030092.
OMAiFERPQDN.
OrthoDBiEOG628F9B.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10513. PTHR10513. 1 hit.
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000705. DNK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C1G0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVIVLSGPI GAGKSSLTGI LSKYLGTKPF YESVDDNPVL PLFYADPKKY
60 70 80 90 100
AFLLQVYFLN TRFHSIKNAL TQDNNVLDRS IYEDALFFQM NADIGRATSE
110 120 130 140 150
EVDTYYELLH NMMGELDRMP KKNPDLLVHI NVSYDTMIKR IKKRGRPYEQ
160 170 180 190 200
LSYDSTLEDY YKRLLRYYKP WYEKYDYSPK MVIDGDKYDF MSSEADREIV
210 220
LDQIVDKLKE VGKLPMDWDK STDIQIEA
Length:228
Mass (Da):26,691
Last modified:January 23, 2007 - v2
Checksum:i6AD4F19B283B6C37
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000033 Genomic DNA. Translation: AAV43745.1.
RefSeqiYP_194776.1. NC_006814.3.

Genome annotation databases

EnsemblBacteriaiAAV43745; AAV43745; LBA1950.
GeneIDi3251915.
KEGGilac:LBA1950.
PATRICi22198905. VBILacAci7974_1854.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000033 Genomic DNA. Translation: AAV43745.1 .
RefSeqi YP_194776.1. NC_006814.3.

3D structure databases

ProteinModelPortali P0C1G0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272621.LBA1950.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV43745 ; AAV43745 ; LBA1950 .
GeneIDi 3251915.
KEGGi lac:LBA1950.
PATRICi 22198905. VBILacAci7974_1854.

Phylogenomic databases

eggNOGi COG1428.
HOGENOMi HOG000030092.
OMAi FERPQDN.
OrthoDBi EOG628F9B.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10513. PTHR10513. 1 hit.
Pfami PF01712. dNK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000705. DNK. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Entry informationi

Entry nameiDGK2_LACAC
AccessioniPrimary (citable) accession number: P0C1G0
Secondary accession number(s): Q59484, Q5FHS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3