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Protein

Deoxyguanosine kinase

Gene

LBA1950

Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DGK/DAK plays an essential role in generating the deoxyribonucleotide precursors, dGTP and dATP, for DNA metabolism.By similarity

Catalytic activityi

ATP + deoxyguanosine = ADP + dGMP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32SubstrateBy similarity1
Binding sitei44SubstrateBy similarity1
Binding sitei55SubstrateBy similarity1
Active sitei78Proton acceptorSequence analysis1
Binding sitei79SubstrateBy similarity1
Binding sitei84SubstrateBy similarity1
Binding sitei149SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 16ATPBy similarity9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLACI272621:GJO8-1882-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyguanosine kinase (EC:2.7.1.113)
Short name:
DGK
Short name:
DGUO kinase
Alternative name(s):
Deoxynucleoside kinase complex I F-component
Gene namesi
Ordered Locus Names:LBA1950
OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Taxonomic identifieri272621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000006381 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001750962 – 228Deoxyguanosine kinaseAdd BLAST227

Interactioni

Subunit structurei

Heterodimer of a deoxyadenosine (DAK) and a deoxyguanosine kinase (DGK).By similarity

Protein-protein interaction databases

STRINGi272621.LBA1950.

Structurei

3D structure databases

ProteinModelPortaliP0C1G0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DCK/DGK family.Curated

Phylogenomic databases

eggNOGiENOG4105ZMH. Bacteria.
COG1428. LUCA.
HOGENOMiHOG000030092.
OMAiYRYIVVE.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DCK/DGK.
IPR031314. DNK_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000705. DNK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C1G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVIVLSGPI GAGKSSLTGI LSKYLGTKPF YESVDDNPVL PLFYADPKKY
60 70 80 90 100
AFLLQVYFLN TRFHSIKNAL TQDNNVLDRS IYEDALFFQM NADIGRATSE
110 120 130 140 150
EVDTYYELLH NMMGELDRMP KKNPDLLVHI NVSYDTMIKR IKKRGRPYEQ
160 170 180 190 200
LSYDSTLEDY YKRLLRYYKP WYEKYDYSPK MVIDGDKYDF MSSEADREIV
210 220
LDQIVDKLKE VGKLPMDWDK STDIQIEA
Length:228
Mass (Da):26,691
Last modified:January 23, 2007 - v2
Checksum:i6AD4F19B283B6C37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000033 Genomic DNA. Translation: AAV43745.1.
RefSeqiWP_003549464.1. NC_006814.3.
YP_194776.1. NC_006814.3.

Genome annotation databases

EnsemblBacteriaiAAV43745; AAV43745; LBA1950.
GeneIDi3251915.
KEGGilac:LBA1950.
PATRICi22198905. VBILacAci7974_1854.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000033 Genomic DNA. Translation: AAV43745.1.
RefSeqiWP_003549464.1. NC_006814.3.
YP_194776.1. NC_006814.3.

3D structure databases

ProteinModelPortaliP0C1G0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272621.LBA1950.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV43745; AAV43745; LBA1950.
GeneIDi3251915.
KEGGilac:LBA1950.
PATRICi22198905. VBILacAci7974_1854.

Phylogenomic databases

eggNOGiENOG4105ZMH. Bacteria.
COG1428. LUCA.
HOGENOMiHOG000030092.
OMAiYRYIVVE.

Enzyme and pathway databases

BioCyciLACI272621:GJO8-1882-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DCK/DGK.
IPR031314. DNK_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000705. DNK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDGK2_LACAC
AccessioniPrimary (citable) accession number: P0C1G0
Secondary accession number(s): Q59484, Q5FHS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.