P0C1F9 (DGK1_LACAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyadenosine kinase
Short name=DADO kinase
Short name=DAK
EC=2.7.1.76

Alternative name(s):
Deoxynucleoside kinase complex I S-component

Gene names

Ordered Locus Names:

LBA1949

Organism

Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) [Complete proteome] [HAMAP]

Taxonomic identifier

272621 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus acidophilus

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DGK/DAK plays an essential role in generating the deoxyribonucleotide precursors, dGTP and dATP, for DNA metabolism By similarity.
Catalytic activity	ATP + deoxyadenosine = ADP + dAMP.
Subunit structure	Heterodimer of a deoxyadenosine (DAK) and a deoxyguanosine kinase (DGK) By similarity.
Sequence similarities	Belongs to the DCK/DGK family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dAMP biosynthetic process Inferred from electronic annotation. Source: GOC
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW deoxyadenosine kinase activity Inferred from electronic annotation. Source: EC phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 215	214	Deoxyadenosine kinase		PRO_0000175095
Regions
	Nucleotide binding	9 – 17	9	ATP By similarity
Sites
	Active site	79	1	Proton acceptor Potential
	Binding site	33	1	Substrate By similarity
	Binding site	45	1	Substrate By similarity
	Binding site	56	1	Substrate By similarity
	Binding site	80	1	Substrate By similarity
	Binding site	85	1	Substrate By similarity
	Binding site	150	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C1F9 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: D809444D93676648	FASTA	215	24,780
	10 20 30 40 50 60 MIQVIVLSGP IGAGKSSLTS ILAEHLGTQA FYEGVDSNPV LPLYYKDMKR YTFLLNTYLL 70 80 90 100 110 120 NHRLAQINQA IQEKNSVSDR SIYEDALFFK MNADSSVADP TEFKIYNDLL ENMMEDTPGN 130 140 150 160 170 180 PSKKPDLLIY IHVSLDTMLK RIKKRGRSFE QISTDPSLKD YYARLLKYYE PWYENYNASP 190 200 210 KIMINGDKLD FVTNMNAQKE VLKEIDEKLR EIGNL

References

[1]

"Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM." Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L., McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S., Hamrick A., Cano R., Klaenhammer T.R. Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000033 Genomic DNA. Translation: AAV43744.1.
RefSeq	YP_194775.1. NC_006814.3.
3D structure databases
ProteinModelPortal	P0C1F9.
ModBase	Search...
Protein-protein interaction databases
STRING	272621.LBA1949.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAV43744; AAV43744; LBA1949.
GeneID	3251913.
KEGG	lac:LBA1949.
PATRIC	22198903. VBILacAci7974_1853.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1428.
HOGENOM	HOG000030092.
OMA	TYLLNHR.
ProtClustDB	CLSK925552.
Family and domain databases
InterPro	IPR002624. Deoxynucleoside_kinase. [Graphical view]
PANTHER	PTHR10513. PTHR10513. 1 hit.
Pfam	PF01712. dNK. 1 hit. [Graphical view]
PIRSF	PIRSF000705. DNK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DGK1_LACAC

Accession

Primary (citable) accession number: P0C1F9
Secondary accession number(s): Q59483, Q5FHT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program