P0C1E5 (P5CR_CORML) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrroline-5-carboxylate reductase
Short name=P5C reductase
Short name=P5CR
EC=1.5.1.2

Gene names

Name:

proC

Organism

Corynebacterium melassecola

Taxonomic identifier

41643 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Pyrroline-5-carboxylate reductase		PRO_0000236038

Sequences

	Sequence		Length	Mass (Da)
	P0C1E5 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 90150E233D94158F	FASTA	270	28,223
	10 20 30 40 50 60 MTTIAVIGGG QIGEALVSGL IAANMNPQNI RVTNRSEERG QELRDRYGIL NMTDNSQAAD 70 80 90 100 110 120 EADVVFLCVK PKFIVEVLSE ITGTLDNNSA QSVVVSMAAG ISIAAMEESA SAGLPVVRVM 130 140 150 160 170 180 PNTPMLVGKG MSTVTKGRYV DAEQLEQVKD LLSTVGDVLE VAESDIDAVT AMSGSSPAYL 190 200 210 220 230 240 FLVTEALIEA GVNLGLPRAT AKKLAVASFE GAATMMKETG KEPSELRAGV SSPAGTTVAA 250 260 270 IRELEESGIR GAFYRAAQAC ADRSEELGKH

References

[1]	"Mutations in the Corynebacterium glutamicum proline biosynthetic pathway: a natural bypass of the proA step." Ankri S., Serebrijski I., Reyes O., Leblon G. J. Bacteriol. 178:4412-4419(1996) [PubMed: 8755867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 17965 / AS B-4821.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U31225 Genomic DNA. Translation: AAC44172.1.
3D structure databases
ProteinModelPortal	P0C1E5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. Pyrroline-COOH_reductase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00112. ProC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR_CORML

Accession

Primary (citable) accession number: P0C1E5
Secondary accession number(s): P46540

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	May 16, 2006
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program