ID   P5CR_CORGL              Reviewed;         270 AA.
AC   P0C1E4; P46540;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Pyrroline-5-carboxylate reductase;
DE            Short=P5C reductase;
DE            Short=P5CR;
DE            EC=1.5.1.2;
GN   Name=proC; OrderedLocusNames=Cgl0410, cg0490;
OS   Corynebacterium glutamicum (Brevibacterium flavum).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Corynebacteriaceae; Corynebacterium.
OX   NCBI_TaxID=1718;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
RA   Nakagawa S.;
RT   "Complete genomic sequence of Corynebacterium glutamicum ATCC 13032.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
RX   MEDLINE=22830012; PubMed=12948626; DOI=10.1016/S0168-1656(03)00154-8;
RA   Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M.,
RA   Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L.,
RA   Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B.,
RA   McHardy A.C., Meyer F., Moeckel B., Pfefferle W., Puehler A.,
RA   Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I.,
RA   Tauch A.;
RT   "The complete Corynebacterium glutamicum ATCC 13032 genome sequence
RT   and its impact on the production of L-aspartate-derived amino acids
RT   and vitamins.";
RL   J. Biotechnol. 104:5-25(2003).
CC   -!- CATALYTIC ACTIVITY: L-proline + NAD(P)(+) = 1-pyrroline-5-
CC       carboxylate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       proline from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase
CC       family.
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DR   EMBL; BA000036; BAB97803.1; -; Genomic_DNA.
DR   EMBL; BX927149; CAF19126.1; -; Genomic_DNA.
DR   RefSeq; NP_599658.1; -.
DR   RefSeq; YP_224712.1; -.
DR   GeneID; 1021078; -.
DR   GeneID; 3343255; -.
DR   GenomeReviews; BA000036_GR; Cgl0410.
DR   GenomeReviews; BX927147_GR; cg0490.
DR   KEGG; cgb:cg0490; -.
DR   KEGG; cgl:NCgl0398; -.
DR   HOGENOM; P0C1E4; -.
DR   OMA; P0C1E4; LKQGYPA.
DR   BioCyc; CGLU196627-1:CG0490-MON; -.
DR   BRENDA; 1.5.1.2; 812.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR004455; NADP_OxRdtase_F420.
DR   InterPro; IPR000304; P5CR.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR11645; P5CR; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR   TIGRFAMs; TIGR00112; proC; 1.
DR   PROSITE; PS00521; P5CR; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP;
KW   Oxidoreductase; Proline biosynthesis.
FT   CHAIN         1    270       Pyrroline-5-carboxylate reductase.
FT                                /FTId=PRO_0000187288.
SQ   SEQUENCE   270 AA;  28242 MW;  85F50E233D94158F CRC64;
     MTTIAVIGGG QIGEALVSGL IAANMNPQNI RVTNRSEERG QELRDRYGIL NMTDNSQAAD
     EADVVFLCVK PKFIVEVLSE ITGTLDNNSA QSVVVSMAAG ISIAAMEESA SAGLPVVRVM
     PNTPMLVGKG MSTVTKGRYV DAEQLEQVKD LLSTVGDVLE VAESDIDAVT AMSGSSPAYL
     FLVTEALIEA GVNLGLPRAT AKKLAVASFE GAATMMKETG KEPSELRAGV SSPAGTTVAA
     IRELEESGIR GAFYRAAQAC ADRSEELGKR
//