Reviewed, UniProtKB/Swiss-Prot P0C1E4 (P5CR_CORGL)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase
      Short name=P5C reductase
      Short name=P5CR
    EC=1.5.1.2

Gene names

Name:	proC
Ordered Locus Names:	Cgl0410, cg0490

Organism

Corynebacterium glutamicum (Brevibacterium flavum) [Complete proteome] [HAMAP]

Taxonomic identifier

1718 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Pyrroline-5-carboxylate reductase		PRO_0000187288

Sequences

	Sequence		Length	Mass (Da)
	P0C1E4-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 85F50E233D94158F	FASTA	270	28,242
	10 20 30 40 50 60 MTTIAVIGGG QIGEALVSGL IAANMNPQNI RVTNRSEERG QELRDRYGIL NMTDNSQAAD 70 80 90 100 110 120 EADVVFLCVK PKFIVEVLSE ITGTLDNNSA QSVVVSMAAG ISIAAMEESA SAGLPVVRVM 130 140 150 160 170 180 PNTPMLVGKG MSTVTKGRYV DAEQLEQVKD LLSTVGDVLE VAESDIDAVT AMSGSSPAYL 190 200 210 220 230 240 FLVTEALIEA GVNLGLPRAT AKKLAVASFE GAATMMKETG KEPSELRAGV SSPAGTTVAA 250 260 270 IRELEESGIR GAFYRAAQAC ADRSEELGKR

References

[1]

"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032." Nakagawa S. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

[2]

"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins." Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A. J. Biotechnol. 104:5-25(2003) [PubMed: 12948626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000036 Genomic DNA. Translation: BAB97803.1. BX927149 Genomic DNA. Translation: CAF19126.1.
RefSeq	NP_599658.1. YP_224712.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1021078. 3343255.
GenomeReviews	Gene locus cg0490 in contig BX927147_GR. Gene locus Cgl0410 in contig BA000036_GR.
KEGG	cgb:cg0490. cgl:NCgl0398.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P0C1E4.
Enzyme and pathway databases
BioCyc	CGLU196627-1:CG0490-MON.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR_CORGL

Accession

Primary (citable) accession number: P0C1E4
Secondary accession number(s): P46540

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	May 16, 2006
Last modified:	November 25, 2008
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)