Reviewed, UniProtKB/Swiss-Prot P0C1D5 (URE21_BRUAB)

Names and origin

Protein names

Recommended name:
    Urease subunit beta 1
    EC=3.5.1.5
Alternative name(s):
    Urea amidohydrolase subunit beta 1

Gene names

Name:	ureB1
Ordered Locus Names:	BruAb1_0295

Organism

Brucella abortus [Complete proteome] [HAMAP]

Taxonomic identifier

235 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Urea + H2O = CO2 + 2 NH3. HAMAP MF_01954
Pathway	Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. HAMAP MF_01954
Subunit structure	Heterotrimer of ureA (gamma), ureB (beta) and ureC (alpha) subunits. Three heterotrimers associate to form the active enzyme By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the urease beta subunit family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nickel ion binding Inferred from electronic annotation. Source: InterPro urease activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 101	101	Urease subunit beta 1 HAMAP MF_01954		PRO_0000234232

Sequences

	Sequence		Length	Mass (Da)
	P0C1D5-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: EC6F5DA786479D39	FASTA	101	11,337
	10 20 30 40 50 60 MIPGEIITLE GDIELNQGQP TVTMRVANTG DRPIQVGSHF HFYEVNAALS FDREKARGQR 70 80 90 100 LDIAAGTAVR FEPGQERDVT LVPIRGHREI YGFRQMIMGK L

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017223 Genomic DNA. Translation: AAX73698.1.
RefSeq	YP_221059.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3340849.
GenomeReviews	Gene locus BruAb1_0295 in contig AE017223_GR.
KEGG	bmb:BruAb1_0295.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P0C1D5.
OMA	PGELELN
Enzyme and pathway databases
BioCyc	BABO262698:BRUAB1_0295-MON.
BRENDA	3.5.1.5. 575.
Family and domain databases
HAMAP	MF_01954. [Tree]
InterPro	IPR002019. Urease_beta. [Graphical view]
Gene3D	G3DSA:2.10.150.10. Urease_beta. 1 hit.
Pfam	PF00699. Urease_beta. 1 hit. [Graphical view]
TIGRFAMs	TIGR00192. urease_beta. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URE21_BRUAB

Accession

Primary (citable) accession number: P0C1D5
Secondary accession number(s): Q57F86, Q93T82

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	May 16, 2006
Last modified:	November 24, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)