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Protein

Protein W

Gene

P/V/C

Organism
Nipah virus
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Prevent the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta). Interacts with host STAT1 protein in the nucleus, blocking it's phosphorylation by IFN-alpha/beta. Also blocks antiviral state induced by Toll-like receptor 3/TLR3 binding to dsRNA.

Miscellaneous

The P/V/C gene has two overlapping open reading frames. One encodes the P/V/W proteins and the other the C protein.

GO - Biological processi

Keywordsi

Biological processInterferon antiviral system evasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein W
Gene namesi
Name:P/V/C
OrganismiNipah virus
Taxonomic identifieri121791 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeHenipavirus
Virus hostiCynopterus brachyotis (Lesser short-nosed fruit bat) (Pachysoma brachyotis) [TaxID: 58060]
Eonycteris spelaea (Lesser dawn bat) (Macroglossus spelaeus) [TaxID: 58065]
Homo sapiens (Human) [TaxID: 9606]
Pteropus hypomelanus (Island flying fox) (Variable flying fox) [TaxID: 9405]
Pteropus vampyrus (Large flying fox) [TaxID: 132908]
Scotophilus kuhlii (Lesser asiatic yellow bat) [TaxID: 153297]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000002330 Componenti: Genome
  • UP000008676 Componenti: Genome
  • UP000007527 Componenti: Genome
  • UP000170143 Componenti: Genome
  • UP000100567 Componenti: Genome
  • UP000130871 Componenti: Genome
  • UP000110983 Componenti: Genome

Subcellular locationi

  • Host nucleus 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi418 – 419RK → AA: No effect on nuclear localization. 1 Publication2
Mutagenesisi424 – 425RR → AA: No effect on nuclear localization. 1 Publication2
Mutagenesisi439 – 442KKAR → AAAA: Complete loss of nuclear localization. 1 Publication4
Mutagenesisi446 – 447RR → AA: No effect on nuclear localization. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002360171 – 450Protein WAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei257Phosphoserine; by hostBy similarity1
Modified residuei350Phosphoserine; by hostBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with host STAT1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ChukQ606802EBI-6151115,EBI-646245From Mus musculus.

Protein-protein interaction databases

IntActiP0C1C7. 30 interactors.

Structurei

3D structure databases

SMRiP0C1C7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi439 – 442Nuclear localization signal4

Phylogenomic databases

OrthoDBiVOG090002DB.

Family and domain databases

InterProiView protein in InterPro
IPR035430. Paramyxo_PNT.
IPR025909. Soyouz_module.
PfamiView protein in Pfam
PF14320. Paramyxo_PCT. 1 hit.
PF14313. Soyouz_module. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C1C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLELVNDG LNIIDFIQKN QKEIQKTYGR SSIQQPSIKD QTKAWEDFLQ
60 70 80 90 100
CTSGESEQVE GGMSKDDGDV ERRNLEDLSS TSPTDGTIGK RVSNTRDWAE
110 120 130 140 150
GSDDIQLDPV VTDVVYHDHG GECTGYGFTS SPERGWSDYT SGANNGNVCL
160 170 180 190 200
VSDAKMLSYA PEIAVSKEDR ETDLVHLENK LSTTGLNPTA VPFTLRNLSD
210 220 230 240 250
PAKDSPVIAE HYYGLGVKEQ NVGPQTSRNV NLDSIKLYTS DDEEADQLEF
260 270 280 290 300
EDEFAGSSSE VIVGISPEDE EPSSVGGKPN ESIGRTIEGQ SIRDNLQAKD
310 320 330 340 350
NKSTDVPGAG PKDSAVKEEP PQKRLPMLAE EFECSGSEDP IIRELLKENS
360 370 380 390 400
LINCQQGKDA QPPYHWSIER SISPDKTEIV NGAVQTADRQ RPGTPMPKSR
410 420 430 440 450
GIPIKKGAQT RNIHLLGRKT CLGRRVVQPG MFEDHPPTKK ARVSMRRMSN
Length:450
Mass (Da):49,522
Last modified:May 16, 2006 - v1
Checksum:i20E3337B5DF486C2
GO

RNA editingi

Edited at position 406.By similarity
Partially edited. RNA editing at this position consists of an insertion of one or two guanine nucleotides. The sequence displayed here is the W protein, derived from the +2G edited RNA. The unedited RNA gives rise to the P protein (AC Q9IK91), the +1G edited RNA gives rise to the V protein (AC Q997F2) (By similarity).By similarity

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti206P → L in strain: Isolate Malaysian flying-fox. 1
Natural varianti274S → R in strain: Isolate NV/MY/99/VRI-0626. 1
Natural varianti304T → A in strain: Isolate NV/MY/99/VRI-0626. 1
Natural varianti378E → K in strain: Isolate NV/MY/99/VRI-0626. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212302 Genomic RNA. No translation available.
AY029768 Genomic RNA. No translation available.
AY029767 Genomic RNA. No translation available.
AF376747 Genomic RNA. No translation available.
AJ564621 Genomic RNA. No translation available.
AJ564622 Genomic RNA. No translation available.
AJ564623 Genomic RNA. No translation available.
AJ627196 Genomic RNA. No translation available.

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiW_NIPAV
AccessioniPrimary (citable) accession number: P0C1C7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: August 30, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome