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P0C1B7

- DORT_PARTR

UniProt

P0C1B7 - DORT_PARTR

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Protein

Dortoxin

Gene
N/A
Organism
Parabuthus transvaalicus (South African fattail scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Binds to sodium channels (Nav) and affects the channel activation process (By similarity). In mice, causes hyperactivity that persists until death.By similarity

GO - Molecular functioni

  1. ion channel inhibitor activity Source: InterPro

GO - Biological processi

  1. defense response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Dortoxin
Alternative name(s):
Dorsotoxin
OrganismiParabuthus transvaalicus (South African fattail scorpion)
Taxonomic identifieri170972 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeParabuthus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5858DortoxinPRO_0000233630Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi18 ↔ 41By similarity
Disulfide bondi27 ↔ 46By similarity
Disulfide bondi31 ↔ 48By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP0C1B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
IPR002061. Scorpion_toxinL/defensin.
[Graphical view]
PfamiPF00537. Toxin_3. 1 hit.
[Graphical view]
SMARTiSM00505. Knot1. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C1B7-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
ADVPGNYPLD KDGNTYTCLK LGENKDCQKV CKLHGVQYGY CYAFECWCKE

YLDDKDSV
Length:58
Mass (Da):6,648
Last modified:May 2, 2006 - v1
Checksum:i732B4ED9FC645260
GO

Mass spectrometryi

Molecular mass is 6641.4 Da from positions 1 - 58. Determined by ESI. 1 Publication

Cross-referencesi

3D structure databases

ProteinModelPortali P0C1B7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.30.10. 1 hit.
InterProi IPR003614. Scorpion_toxin-like.
IPR002061. Scorpion_toxinL/defensin.
[Graphical view ]
Pfami PF00537. Toxin_3. 1 hit.
[Graphical view ]
SMARTi SM00505. Knot1. 1 hit.
[Graphical view ]
SUPFAMi SSF57095. SSF57095. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Three structurally related, highly potent, peptides from the venom of Parabuthus transvaalicus possess divergent biological activity."
    Inceoglu A.B., Lango J., Pessah I.N., Hammock B.D.
    Toxicon 45:727-733(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY.
    Tissue: Venom.

Entry informationi

Entry nameiDORT_PARTR
AccessioniPrimary (citable) accession number: P0C1B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: October 29, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3