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Protein

Argininosuccinate synthase

Gene

argG

Organism
Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

Pathwayi

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
OrganismiDickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi)
Taxonomic identifieri556 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 242›242Argininosuccinate synthasePRO_0000148699Add
BLAST

Proteomic databases

PRIDEiP0C1A0.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0C1A0.
SMRiP0C1A0. Positions 1-233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.287.400. 1 hit.
3.90.1260.10. 1 hit.
InterProiIPR001518. Arginosuc_synth.
IPR024074. AS_cat/multimer_dom_body.
IPR024073. AS_multimer_C_tail.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P0C1A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EFLNSSVKIV NPIMGVKFWD ENVRIPAEEV TVRFERGHPV ALNGQTFSDD
60 70 80 90 100
VELLLEANRI GGRHGLGMSD QIENRIIEAK SRGIYEAPGM ALLHIAYERL
110 120 130 140 150
VTGIHNEDTI EQYHAHGRQL GRLLYQGRWF DPQALMLRDA LQRWVASEIT
160 170 180 190 200
GEVTLELRRG NDYSILNTVS DNLTYKPERL TMEKGESVFS PDDRIGQLTM
210 220 230 240
RNLDITDTRE KLFNYVESGL ISSGNAGLPQ VANPLLQDKS AK
Length:242
Mass (Da):27,349
Last modified:April 18, 2006 - v1
Checksum:iBF3C91A7FD7D49D5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF265211 Genomic DNA. Translation: AAF74776.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF265211 Genomic DNA. Translation: AAF74776.1.

3D structure databases

ProteinModelPortaliP0C1A0.
SMRiP0C1A0. Positions 1-233.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP0C1A0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Family and domain databases

Gene3Di1.10.287.400. 1 hit.
3.90.1260.10. 1 hit.
InterProiIPR001518. Arginosuc_synth.
IPR024074. AS_cat/multimer_dom_body.
IPR024073. AS_multimer_C_tail.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of genes involved in blue pigment synthesis from Erwinia chrysanthemi RA3B."
    Huang H.-C., Chu M.-K., Hsu S.-T., Tzeng K.-C., Lin R.-H.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RA3B.

Entry informationi

Entry nameiASSY_DICCH
AccessioniPrimary (citable) accession number: P0C1A0
Secondary accession number(s): P42181, Q9KHB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: January 7, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.