P0C1A0 (ASSY_ERWCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate synthase
EC=6.3.4.5

Alternative name(s):
Citrulline--aspartate ligase

Gene names

Name:

argG

Organism

Erwinia chrysanthemi

Taxonomic identifier

556 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Dickeya

Protein attributes

Sequence length	242 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP-Rule MF_00581
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP-Rule MF_00581
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the argininosuccinate synthase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Gene Ontology (GO)
Biological_process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW argininosuccinate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 242	›242	Argininosuccinate synthase HAMAP-Rule MF_00581		PRO_0000148699
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P0C1A0 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: BF3C91A7FD7D49D5	FASTA	242	27,349
	10 20 30 40 50 60 EFLNSSVKIV NPIMGVKFWD ENVRIPAEEV TVRFERGHPV ALNGQTFSDD VELLLEANRI 70 80 90 100 110 120 GGRHGLGMSD QIENRIIEAK SRGIYEAPGM ALLHIAYERL VTGIHNEDTI EQYHAHGRQL 130 140 150 160 170 180 GRLLYQGRWF DPQALMLRDA LQRWVASEIT GEVTLELRRG NDYSILNTVS DNLTYKPERL 190 200 210 220 230 240 TMEKGESVFS PDDRIGQLTM RNLDITDTRE KLFNYVESGL ISSGNAGLPQ VANPLLQDKS AK

References

[1]	"Molecular cloning of genes involved in blue pigment synthesis from Erwinia chrysanthemi RA3B." Huang H.-C., Chu M.-K., Hsu S.-T., Tzeng K.-C., Lin R.-H. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: RA3B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF265211 Genomic DNA. Translation: AAF74776.1.
3D structure databases
ProteinModelPortal	P0C1A0.
SMR	P0C1A0. Positions 1-233.
ModBase	Search...
Proteomic databases
PRIDE	P0C1A0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00068; UER00113.
Family and domain databases
Gene3D	1.10.287.400. 1 hit. 3.90.1260.10. 1 hit.
HAMAP	MF_00581. Arg_succ_synth_type2.
InterPro	IPR001518. Arginosuc_synth. IPR024074. AS_cat/multimer_dom_body. IPR024073. AS_multimer_C_tail. [Graphical view]
PANTHER	PTHR11587. PTHR11587. 1 hit.
Pfam	PF00764. Arginosuc_synth. 1 hit. [Graphical view]
PROSITE	PS00564. ARGININOSUCCIN_SYN_1. Partial match. PS00565. ARGININOSUCCIN_SYN_2. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASSY_ERWCH

Accession

Primary (citable) accession number: P0C1A0
Secondary accession number(s): P42181, Q9KHB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
Last sequence update:	April 18, 2006
Last modified:	March 6, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program