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P0C191

- GPVI_MOUSE

UniProt

P0C191 - GPVI_MOUSE

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Protein
Platelet glycoprotein VI
Gene
Gp6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.3 Publications

GO - Molecular functioni

  1. collagen binding Source: MGI

GO - Biological processi

  1. blood coagulation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiREACT_220092. GPVI-mediated activation cascade.
REACT_225107. Platelet Adhesion to exposed collagen.
REACT_225233. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein VI
Short name:
GPVI
Alternative name(s):
Glycoprotein 5
Gene namesi
Name:Gp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1889810. Gp6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 265244Extracellular Reviewed prediction
Add
BLAST
Transmembranei266 – 28621Helical; Reviewed prediction
Add
BLAST
Topological domaini287 – 31327Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 313292Platelet glycoprotein VI
PRO_0000232384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 89 By similarity
Glycosylationi93 – 931N-linked (GlcNAc...) By similarity
Disulfide bondi135 ↔ 181 By similarity
Glycosylationi244 – 2441N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP0C191.
PRIDEiP0C191.

PTM databases

PhosphoSiteiP0C191.

Expressioni

Tissue specificityi

Megakaryocytes and platelets.1 Publication

Developmental stagei

Expressed at embryonic day 13.5, 14.5 and 16.5. Expression decreases in intensity at day 18.5 and in 1.5 day-old newborn.1 Publication

Gene expression databases

BgeeiP0C191.
GenevestigatoriP0C191.

Interactioni

Subunit structurei

Associated with Fc receptor gamma chain. The GPVI-FcRgamma complex is associated with the Src kinase family Fyn and Lyn By similarity.

Structurei

3D structure databases

ProteinModelPortaliP0C191.
SMRiP0C191. Positions 23-204.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 10579Ig-like C2-type 1
Add
BLAST
Domaini115 – 19783Ig-like C2-type 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi183 – 1886Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG79029.
GeneTreeiENSGT00710000106246.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiP0C191.
KOiK06264.
OMAiHECESRR.
OrthoDBiEOG78SQGZ.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C191-1 [UniParc]FASTAAdd to Basket

« Hide

MSPASPTFFC IGLCVLQVIQ TQSGPLPKPS LQAQPSSLVP LGQSVILRCQ    50
GPPDVDLYRL EKLKPEKYED QDFLFIPTME RSNAGRYRCS YQNGSHWSLP 100
SDQLELIATG VYAKPSLSAH PSSAVPQGRD VTLKCQSPYS FDEFVLYKEG 150
DTGSYKRPEK WYRANFPIIT VTAAHSGTYR CYSFSSSSPY LWSAPSDPLV 200
LVVTGLSATP SQVPTEESFP VTESSRRPSI LPTNKISTTE KPMNITASPE 250
GLSPPFGFAH QHYAKGNLVR ICLGATIIII LLGLLAEDWH SRKKCLQHRM 300
RALQRPLPPL PLA 313
Length:313
Mass (Da):34,595
Last modified:July 27, 2011 - v2
Checksum:i34D810EAE120C535
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti256 – 2561F → I no nucleotide entry 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC137969 Genomic DNA. No translation available.
CCDSiCCDS51972.1.
RefSeqiNP_001156486.1. NM_001163014.1.
UniGeneiMm.248662.

Genome annotation databases

EnsembliENSMUST00000108590; ENSMUSP00000104231; ENSMUSG00000078810.
GeneIDi243816.
KEGGimmu:243816.
UCSCiuc009exk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC137969 Genomic DNA. No translation available.
CCDSi CCDS51972.1.
RefSeqi NP_001156486.1. NM_001163014.1.
UniGenei Mm.248662.

3D structure databases

ProteinModelPortali P0C191.
SMRi P0C191. Positions 23-204.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P0C191.

Proteomic databases

PaxDbi P0C191.
PRIDEi P0C191.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000108590 ; ENSMUSP00000104231 ; ENSMUSG00000078810 .
GeneIDi 243816.
KEGGi mmu:243816.
UCSCi uc009exk.2. mouse.

Organism-specific databases

CTDi 51206.
MGIi MGI:1889810. Gp6.

Phylogenomic databases

eggNOGi NOG79029.
GeneTreei ENSGT00710000106246.
HOGENOMi HOG000234395.
HOVERGENi HBG074353.
InParanoidi P0C191.
KOi K06264.
OMAi HECESRR.
OrthoDBi EOG78SQGZ.
TreeFami TF336644.

Enzyme and pathway databases

Reactomei REACT_220092. GPVI-mediated activation cascade.
REACT_225107. Platelet Adhesion to exposed collagen.
REACT_225233. Cell surface interactions at the vascular wall.

Miscellaneous databases

NextBioi 385930.
PROi P0C191.
SOURCEi Search...

Gene expression databases

Bgeei P0C191.
Genevestigatori P0C191.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily."
    Jandrot-Perrus M., Busfield S., Lagrue A.-H., Xiong X., Debili N., Chickering T., Le Couedic J.-P., Goodearl A., Dussault B., Fraser C., Vainchenker W., Villeval J.-L.
    Blood 96:1798-1807(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH FC RECEPTOR GAMMA CHAIN, DEVELOPMENTAL STAGE.
    Tissue: Megakaryocyte.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The glycoprotein VI-phospholipase Cgamma2 signaling pathway controls thrombus formation induced by collagen and tissue factor in vitro and in vivo."
    Munnix I.C., Strehl A., Kuijpers M.J., Auger J.M., van der Meijden P.E., van Zandvoort M.A., oude Egbrink M.G., Nieswandt B., Heemskerk J.W.
    Arterioscler. Thromb. Vasc. Biol. 25:2673-2678(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism."
    Lockyer S., Okuyama K., Begum S., Le S., Sun B., Watanabe T., Matsumoto Y., Yoshitake M., Kambayashi J., Tandon N.N.
    Thromb. Res. 118:371-380(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGPVI_MOUSE
AccessioniPrimary (citable) accession number: P0C191
Secondary accession number(s): E9QPN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Mice deficient in GPVI show a complete protection against arterial thrombosis and induced pulmonary thromboembolism, without significant prolongation of bleeding time.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi