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P0C191 (GPVI_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Platelet glycoprotein VI

Short name=GPVI
Alternative name(s):
Glycoprotein 5
Gene names
Name:Gp6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. Ref.1 Ref.3 Ref.4

Subunit structure

Associated with Fc receptor gamma chain. The GPVI-FcRgamma complex is associated with the Src kinase family Fyn and Lyn By similarity.

Subcellular location

Membrane; Single-pass membrane protein By similarity.

Tissue specificity

Megakaryocytes and platelets. Ref.1

Developmental stage

Expressed at embryonic day 13.5, 14.5 and 16.5. Expression decreases in intensity at day 18.5 and in 1.5 day-old newborn. Ref.1

Miscellaneous

Mice deficient in GPVI show a complete protection against arterial thrombosis and induced pulmonary thromboembolism, without significant prolongation of bleeding time.

Sequence similarities

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
   Biological processBlood coagulation
Hemostasis
   Cellular componentMembrane
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processblood coagulation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of plasma membrane

Inferred from direct assay Ref.1. Source: MGI

   Molecular_functioncollagen binding

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 313292Platelet glycoprotein VI
PRO_0000232384

Regions

Topological domain22 – 265244Extracellular Potential
Transmembrane266 – 28621Helical; Potential
Topological domain287 – 31327Cytoplasmic Potential
Domain27 – 10579Ig-like C2-type 1
Domain115 – 19783Ig-like C2-type 2
Compositional bias183 – 1886Poly-Ser

Amino acid modifications

Glycosylation931N-linked (GlcNAc...) By similarity
Glycosylation2441N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 89 By similarity
Disulfide bond135 ↔ 181 By similarity

Experimental info

Sequence conflict2561F → I no nucleotide entry Ref.1

Sequences

Sequence LengthMass (Da)Tools
P0C191 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 34D810EAE120C535

FASTA31334,595
        10         20         30         40         50         60 
MSPASPTFFC IGLCVLQVIQ TQSGPLPKPS LQAQPSSLVP LGQSVILRCQ GPPDVDLYRL 

        70         80         90        100        110        120 
EKLKPEKYED QDFLFIPTME RSNAGRYRCS YQNGSHWSLP SDQLELIATG VYAKPSLSAH 

       130        140        150        160        170        180 
PSSAVPQGRD VTLKCQSPYS FDEFVLYKEG DTGSYKRPEK WYRANFPIIT VTAAHSGTYR 

       190        200        210        220        230        240 
CYSFSSSSPY LWSAPSDPLV LVVTGLSATP SQVPTEESFP VTESSRRPSI LPTNKISTTE 

       250        260        270        280        290        300 
KPMNITASPE GLSPPFGFAH QHYAKGNLVR ICLGATIIII LLGLLAEDWH SRKKCLQHRM 

       310 
RALQRPLPPL PLA 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily."
Jandrot-Perrus M., Busfield S., Lagrue A.-H., Xiong X., Debili N., Chickering T., Le Couedic J.-P., Goodearl A., Dussault B., Fraser C., Vainchenker W., Villeval J.-L.
Blood 96:1798-1807(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH FC RECEPTOR GAMMA CHAIN, DEVELOPMENTAL STAGE.
Tissue: Megakaryocyte.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The glycoprotein VI-phospholipase Cgamma2 signaling pathway controls thrombus formation induced by collagen and tissue factor in vitro and in vivo."
Munnix I.C., Strehl A., Kuijpers M.J., Auger J.M., van der Meijden P.E., van Zandvoort M.A., oude Egbrink M.G., Nieswandt B., Heemskerk J.W.
Arterioscler. Thromb. Vasc. Biol. 25:2673-2678(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism."
Lockyer S., Okuyama K., Begum S., Le S., Sun B., Watanabe T., Matsumoto Y., Yoshitake M., Kambayashi J., Tandon N.N.
Thromb. Res. 118:371-380(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC137969 Genomic DNA. No translation available.
CCDSCCDS51972.1.
RefSeqNP_001156486.1. NM_001163014.1.
UniGeneMm.248662.

3D structure databases

ProteinModelPortalP0C191.
SMRP0C191. Positions 23-204.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP0C191.

Proteomic databases

PaxDbP0C191.
PRIDEP0C191.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000108590; ENSMUSP00000104231; ENSMUSG00000078810.
GeneID243816.
KEGGmmu:243816.
UCSCuc009exk.2. mouse.

Organism-specific databases

CTD51206.
MGIMGI:1889810. Gp6.

Phylogenomic databases

eggNOGNOG79029.
GeneTreeENSGT00710000106246.
HOGENOMHOG000234395.
HOVERGENHBG074353.
InParanoidP0C191.
KOK06264.
OMAHECESRR.
OrthoDBEOG78SQGZ.
TreeFamTF336644.

Gene expression databases

BgeeP0C191.
GenevestigatorP0C191.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTSM00409. IG. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio385930.
PROP0C191.
SOURCESearch...

Entry information

Entry nameGPVI_MOUSE
AccessionPrimary (citable) accession number: P0C191
Secondary accession number(s): E9QPN2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot