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Protein

Platelet glycoprotein VI

Gene

Gp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.3 Publications

GO - Molecular functioni

  • collagen binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-75892. Platelet Adhesion to exposed collagen.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein VI
Short name:
GPVI
Alternative name(s):
Glycoprotein 5
Gene namesi
Name:Gp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1889810. Gp6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 265244ExtracellularSequence analysisAdd
BLAST
Transmembranei266 – 28621HelicalSequence analysisAdd
BLAST
Topological domaini287 – 31327CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 313292Platelet glycoprotein VIPRO_0000232384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 89By similarity
Glycosylationi93 – 931N-linked (GlcNAc...)By similarity
Disulfide bondi135 ↔ 181By similarity
Glycosylationi244 – 2441N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP0C191.
PaxDbiP0C191.
PRIDEiP0C191.

Expressioni

Tissue specificityi

Megakaryocytes and platelets.1 Publication

Developmental stagei

Expressed at embryonic day 13.5, 14.5 and 16.5. Expression decreases in intensity at day 18.5 and in 1.5 day-old newborn.1 Publication

Gene expression databases

BgeeiENSMUSG00000078810.
GenevisibleiP0C191. MM.

Interactioni

Subunit structurei

Associated with Fc receptor gamma chain. The GPVI-FcRgamma complex is associated with the Src kinase family Fyn and Lyn (By similarity).By similarity

GO - Molecular functioni

  • collagen binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104231.

Structurei

3D structure databases

ProteinModelPortaliP0C191.
SMRiP0C191. Positions 23-204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 10579Ig-like C2-type 1Add
BLAST
Domaini115 – 19783Ig-like C2-type 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi183 – 1886Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHKK. Eukaryota.
ENOG411142H. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiP0C191.
KOiK06264.
OMAiIRCQGPP.
OrthoDBiEOG091G0HU0.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C191-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPASPTFFC IGLCVLQVIQ TQSGPLPKPS LQAQPSSLVP LGQSVILRCQ
60 70 80 90 100
GPPDVDLYRL EKLKPEKYED QDFLFIPTME RSNAGRYRCS YQNGSHWSLP
110 120 130 140 150
SDQLELIATG VYAKPSLSAH PSSAVPQGRD VTLKCQSPYS FDEFVLYKEG
160 170 180 190 200
DTGSYKRPEK WYRANFPIIT VTAAHSGTYR CYSFSSSSPY LWSAPSDPLV
210 220 230 240 250
LVVTGLSATP SQVPTEESFP VTESSRRPSI LPTNKISTTE KPMNITASPE
260 270 280 290 300
GLSPPFGFAH QHYAKGNLVR ICLGATIIII LLGLLAEDWH SRKKCLQHRM
310
RALQRPLPPL PLA
Length:313
Mass (Da):34,595
Last modified:July 27, 2011 - v2
Checksum:i34D810EAE120C535
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti256 – 2561F → I no nucleotide entry (PubMed:10961879).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137969 Genomic DNA. No translation available.
CCDSiCCDS51972.1.
RefSeqiNP_001156486.1. NM_001163014.1.
UniGeneiMm.248662.

Genome annotation databases

EnsembliENSMUST00000206928; ENSMUSP00000145740; ENSMUSG00000078810.
GeneIDi243816.
KEGGimmu:243816.
UCSCiuc009exk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137969 Genomic DNA. No translation available.
CCDSiCCDS51972.1.
RefSeqiNP_001156486.1. NM_001163014.1.
UniGeneiMm.248662.

3D structure databases

ProteinModelPortaliP0C191.
SMRiP0C191. Positions 23-204.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104231.

Proteomic databases

MaxQBiP0C191.
PaxDbiP0C191.
PRIDEiP0C191.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000206928; ENSMUSP00000145740; ENSMUSG00000078810.
GeneIDi243816.
KEGGimmu:243816.
UCSCiuc009exk.2. mouse.

Organism-specific databases

CTDi51206.
MGIiMGI:1889810. Gp6.

Phylogenomic databases

eggNOGiENOG410IHKK. Eukaryota.
ENOG411142H. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiP0C191.
KOiK06264.
OMAiIRCQGPP.
OrthoDBiEOG091G0HU0.
TreeFamiTF336644.

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-75892. Platelet Adhesion to exposed collagen.

Miscellaneous databases

PROiP0C191.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078810.
GenevisibleiP0C191. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGPVI_MOUSE
AccessioniPrimary (citable) accession number: P0C191
Secondary accession number(s): E9QPN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Mice deficient in GPVI show a complete protection against arterial thrombosis and induced pulmonary thromboembolism, without significant prolongation of bleeding time.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.