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P0C191

- GPVI_MOUSE

UniProt

P0C191 - GPVI_MOUSE

Protein

Platelet glycoprotein VI

Gene

Gp6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.3 Publications

    GO - Molecular functioni

    1. collagen binding Source: MGI

    GO - Biological processi

    1. blood coagulation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Blood coagulation, Hemostasis

    Enzyme and pathway databases

    ReactomeiREACT_220092. GPVI-mediated activation cascade.
    REACT_225107. Platelet Adhesion to exposed collagen.
    REACT_225233. Cell surface interactions at the vascular wall.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet glycoprotein VI
    Short name:
    GPVI
    Alternative name(s):
    Glycoprotein 5
    Gene namesi
    Name:Gp6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1889810. Gp6.

    Subcellular locationi

    Membrane By similarity; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 313292Platelet glycoprotein VIPRO_0000232384Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 89By similarity
    Glycosylationi93 – 931N-linked (GlcNAc...)By similarity
    Disulfide bondi135 ↔ 181By similarity
    Glycosylationi244 – 2441N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP0C191.
    PRIDEiP0C191.

    PTM databases

    PhosphoSiteiP0C191.

    Expressioni

    Tissue specificityi

    Megakaryocytes and platelets.1 Publication

    Developmental stagei

    Expressed at embryonic day 13.5, 14.5 and 16.5. Expression decreases in intensity at day 18.5 and in 1.5 day-old newborn.1 Publication

    Gene expression databases

    BgeeiP0C191.
    GenevestigatoriP0C191.

    Interactioni

    Subunit structurei

    Associated with Fc receptor gamma chain. The GPVI-FcRgamma complex is associated with the Src kinase family Fyn and Lyn By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP0C191.
    SMRiP0C191. Positions 23-204.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 265244ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini287 – 31327CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei266 – 28621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 10579Ig-like C2-type 1Add
    BLAST
    Domaini115 – 19783Ig-like C2-type 2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi183 – 1886Poly-Ser

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG79029.
    GeneTreeiENSGT00710000106246.
    HOGENOMiHOG000234395.
    HOVERGENiHBG074353.
    InParanoidiP0C191.
    KOiK06264.
    OMAiHECESRR.
    OrthoDBiEOG78SQGZ.
    TreeFamiTF336644.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C191-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPASPTFFC IGLCVLQVIQ TQSGPLPKPS LQAQPSSLVP LGQSVILRCQ    50
    GPPDVDLYRL EKLKPEKYED QDFLFIPTME RSNAGRYRCS YQNGSHWSLP 100
    SDQLELIATG VYAKPSLSAH PSSAVPQGRD VTLKCQSPYS FDEFVLYKEG 150
    DTGSYKRPEK WYRANFPIIT VTAAHSGTYR CYSFSSSSPY LWSAPSDPLV 200
    LVVTGLSATP SQVPTEESFP VTESSRRPSI LPTNKISTTE KPMNITASPE 250
    GLSPPFGFAH QHYAKGNLVR ICLGATIIII LLGLLAEDWH SRKKCLQHRM 300
    RALQRPLPPL PLA 313
    Length:313
    Mass (Da):34,595
    Last modified:July 27, 2011 - v2
    Checksum:i34D810EAE120C535
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti256 – 2561F → I no nucleotide entry (PubMed:10961879)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC137969 Genomic DNA. No translation available.
    CCDSiCCDS51972.1.
    RefSeqiNP_001156486.1. NM_001163014.1.
    UniGeneiMm.248662.

    Genome annotation databases

    EnsembliENSMUST00000108590; ENSMUSP00000104231; ENSMUSG00000078810.
    GeneIDi243816.
    KEGGimmu:243816.
    UCSCiuc009exk.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC137969 Genomic DNA. No translation available.
    CCDSi CCDS51972.1.
    RefSeqi NP_001156486.1. NM_001163014.1.
    UniGenei Mm.248662.

    3D structure databases

    ProteinModelPortali P0C191.
    SMRi P0C191. Positions 23-204.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P0C191.

    Proteomic databases

    PaxDbi P0C191.
    PRIDEi P0C191.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000108590 ; ENSMUSP00000104231 ; ENSMUSG00000078810 .
    GeneIDi 243816.
    KEGGi mmu:243816.
    UCSCi uc009exk.2. mouse.

    Organism-specific databases

    CTDi 51206.
    MGIi MGI:1889810. Gp6.

    Phylogenomic databases

    eggNOGi NOG79029.
    GeneTreei ENSGT00710000106246.
    HOGENOMi HOG000234395.
    HOVERGENi HBG074353.
    InParanoidi P0C191.
    KOi K06264.
    OMAi HECESRR.
    OrthoDBi EOG78SQGZ.
    TreeFami TF336644.

    Enzyme and pathway databases

    Reactomei REACT_220092. GPVI-mediated activation cascade.
    REACT_225107. Platelet Adhesion to exposed collagen.
    REACT_225233. Cell surface interactions at the vascular wall.

    Miscellaneous databases

    NextBioi 385930.
    PROi P0C191.
    SOURCEi Search...

    Gene expression databases

    Bgeei P0C191.
    Genevestigatori P0C191.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily."
      Jandrot-Perrus M., Busfield S., Lagrue A.-H., Xiong X., Debili N., Chickering T., Le Couedic J.-P., Goodearl A., Dussault B., Fraser C., Vainchenker W., Villeval J.-L.
      Blood 96:1798-1807(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH FC RECEPTOR GAMMA CHAIN, DEVELOPMENTAL STAGE.
      Tissue: Megakaryocyte.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The glycoprotein VI-phospholipase Cgamma2 signaling pathway controls thrombus formation induced by collagen and tissue factor in vitro and in vivo."
      Munnix I.C., Strehl A., Kuijpers M.J., Auger J.M., van der Meijden P.E., van Zandvoort M.A., oude Egbrink M.G., Nieswandt B., Heemskerk J.W.
      Arterioscler. Thromb. Vasc. Biol. 25:2673-2678(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism."
      Lockyer S., Okuyama K., Begum S., Le S., Sun B., Watanabe T., Matsumoto Y., Yoshitake M., Kambayashi J., Tandon N.N.
      Thromb. Res. 118:371-380(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiGPVI_MOUSE
    AccessioniPrimary (citable) accession number: P0C191
    Secondary accession number(s): E9QPN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Mice deficient in GPVI show a complete protection against arterial thrombosis and induced pulmonary thromboembolism, without significant prolongation of bleeding time.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3