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Protein

NAD(P) transhydrogenase subunit beta

Gene

pntB

Organism
Rhodospirillum rubrum
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.By similarity

Catalytic activityi

NADPH + NAD+ = NADP+ + NADH.

GO - Molecular functioni

GO - Biological processi

  • oxidation-reduction process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Protein family/group databases

TCDBi3.D.2.2.1. the proton-translocating transhydrogenase (pth) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P) transhydrogenase subunit beta (EC:1.6.1.2)
Alternative name(s):
Nicotinamide nucleotide transhydrogenase subunit beta
Proton-translocating transhydrogenase NADP(H)-binding component
Pyridine nucleotide transhydrogenase subunit beta
dIII
Gene namesi
Name:pntB
Synonyms:nntB
OrganismiRhodospirillum rubrum
Taxonomic identifieri1085 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001990271 – 464NAD(P) transhydrogenase subunit betaAdd BLAST464

Interactioni

Subunit structurei

Complex of an alpha and a beta chain; in Rhodospirillum, the alpha chain seems to be made of two subunits.

Protein-protein interaction databases

STRINGi269796.Rru_A2181.

Structurei

Secondary structure

1464
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi297 – 306Combined sources10
Beta strandi308 – 314Combined sources7
Helixi316 – 321Combined sources6
Helixi324 – 336Combined sources13
Beta strandi340 – 345Combined sources6
Beta strandi350 – 352Combined sources3
Helixi355 – 362Combined sources8
Helixi367 – 369Combined sources3
Beta strandi370 – 372Combined sources3
Helixi373 – 376Combined sources4
Helixi377 – 379Combined sources3
Beta strandi384 – 390Combined sources7
Helixi393 – 395Combined sources3
Helixi397 – 399Combined sources3
Turni406 – 409Combined sources4
Helixi415 – 417Combined sources3
Beta strandi418 – 428Combined sources11
Helixi438 – 441Combined sources4
Beta strandi445 – 450Combined sources6
Helixi452 – 462Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FR8X-ray2.60C262-464[»]
2FRDX-ray3.20C262-464[»]
2FSVX-ray2.30C262-464[»]
2OO5X-ray2.60C291-464[»]
2OORX-ray2.32C291-464[»]
ProteinModelPortaliP0C188.
SMRiP0C188.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C188.

Family & Domainsi

Sequence similaritiesi

Belongs to the PNT beta subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C15. Bacteria.
COG1282. LUCA.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR012136. NADH_DH_b.
[Graphical view]
PfamiPF02233. PNTB. 1 hit.
[Graphical view]
PIRSFiPIRSF000204. PNTB. 1 hit.
SUPFAMiSSF52467. SSF52467. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C188-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHSLTMAAY IVAGVLFILA LRGLSNPESA RNGNRMGMVG MAIAILTTLL
60 70 80 90 100
SPSVQAYAWI VLAIAIGGAI GTVIAKKVLM TALPQLVAAF HSLVGMAAVL
110 120 130 140 150
VATGALLNPE AYGIGSAGAI HAGSLVEMSL GLAVGAITFS GSVIAFGKLQ
160 170 180 190 200
GLIAGKPVTF PMQHPLNAVL GILLVVLLVV FAATESHTAY FALMILAFAL
210 220 230 240 250
GFLLIIPIGG ADMPVVISML NSYSGWAAAG IGFTLGNPLL IIAGALVGSS
260 270 280 290 300
GAILSYIMCK GMNRSIFNVI LGGFGSEGGV AAAGGAAGDR SVKAGSAEDA
310 320 330 340 350
AFIMKNASKV IIVPGYGMAV AQAQHALREM ADVLKKEGVE VSYAIHPVAG
360 370 380 390 400
RMPGHMNVLL AEANVPYDEV FELEEINSSF QTADVAFVIG ANDVTNPAAK
410 420 430 440 450
TDPSSPIYGM PILDVEKAGT VLFIKRSMAS GYAGVENELF FRNNTMMLFG
460
DAKKMTEQIV QAMN
Length:464
Mass (Da):47,808
Last modified:April 4, 2006 - v1
Checksum:i79200D4F8861779B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01158 Genomic DNA. Translation: AAC43257.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01158 Genomic DNA. Translation: AAC43257.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FR8X-ray2.60C262-464[»]
2FRDX-ray3.20C262-464[»]
2FSVX-ray2.30C262-464[»]
2OO5X-ray2.60C291-464[»]
2OORX-ray2.32C291-464[»]
ProteinModelPortaliP0C188.
SMRiP0C188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269796.Rru_A2181.

Protein family/group databases

TCDBi3.D.2.2.1. the proton-translocating transhydrogenase (pth) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105C15. Bacteria.
COG1282. LUCA.

Miscellaneous databases

EvolutionaryTraceiP0C188.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR012136. NADH_DH_b.
[Graphical view]
PfamiPF02233. PNTB. 1 hit.
[Graphical view]
PIRSFiPIRSF000204. PNTB. 1 hit.
SUPFAMiSSF52467. SSF52467. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPNTB_RHORU
AccessioniPrimary (citable) accession number: P0C188
Secondary accession number(s): Q59763, Q59765
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: November 2, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.