Reviewed, UniProtKB/Swiss-Prot P0C187 (PNTAB_RHORU)

Names and origin

Protein names

Recommended name:
    NAD(P) transhydrogenase subunit alpha part 2
    EC=1.6.1.2
Alternative name(s):
    Nicotinamide nucleotide transhydrogenase subunit alpha 2
    Pyridine nucleotide transhydrogenase subunit alpha 2
    Proton-translocating transhydrogenase component 2
    dII

Gene names

Name:	pntAB
Synonyms:	nntA2

Organism

Rhodospirillum rubrum

Taxonomic identifier

1085 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Rhodospirillum

Protein attributes

Sequence length	139 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane By similarity.
Catalytic activity	NADPH + NAD+ = NADP+ + NADH.
Subunit structure	Complex of an alpha and a beta chain; in Rhodospirillum, the alpha chain seems to be made of two subunits.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Ligand	NAD NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD(P)+ transhydrogenase (AB-specific) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 139	139	NAD(P) transhydrogenase subunit alpha part 2		PRO_0000199021
Regions
	Transmembrane	49 – 69	21	Potential
	Transmembrane	78 – 98	21	Potential
	Transmembrane	107 – 127	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	P0C187-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 04742D87817A8879	FASTA	139	14,889
	10 20 30 40 50 60 MEDKNILVEG FNQLSQQALE LSQHAQALAL QASHAVLPAA AATEGASEFW WLMTVFVLAC 70 80 90 100 110 120 FIGFYVVWSV TPALHSPLMG VTNAISSVIV VGALIATGPE AFSASKVLGF FAILLASVNI 130 FGGFIVTQRM LAMFKKKQK

References

[1]

"Energy-transducing nicotinamide nucleotide transhydrogenase: nucleotide sequences of the genes and predicted amino acid sequences of the subunits of the enzyme from Rhodospirillum rubrum." Yamaguchi M., Hatefi Y. J. Bioenerg. Biomembr. 26:435-445(1994) [PubMed: 7844118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U01158 Genomic DNA. Translation: AAC43256.1.
3D structure databases
ModBase	Search...
Protein family/group databases
TCDB	3.D.2.2.1. proton-translocating transhydrogenase (PTH) family.
Enzyme and pathway databases
BRENDA	1.6.1.2. 1671.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

PNTAB_RHORU

Accession

Primary (citable) accession number: P0C187
Secondary accession number(s): Q59762, Q59764

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	June 16, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)