UniProtKB - P0C183 (KA201_TITTR)
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Protein
Potassium channel toxin alpha-KTx 20.1
Gene
N/A
Organism
Tityus trivittatus (Argentinean scorpion)
Status
Functioni
Reduces potassium currents through Kv1.2/KCNA2 and Kv1.3/KCNA3 voltage-gated potassium channels.1 Publication
Miscellaneous
Has no effect on Kv1.1/KCNA1, Kv1.4/KCNA4, Kv1.5/KCNA5, shaker IR or Kv11.1/KCNH2 channels.1 Publication
Keywordsi
| Molecular function | Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin |
Names & Taxonomyi
| Protein namesi | Recommended name: Potassium channel toxin alpha-KTx 20.1Alternative name(s): Toxin Tt28 |
| Organismi | Tityus trivittatus (Argentinean scorpion) |
| Taxonomic identifieri | 369776 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Tityus |
Subcellular locationi
GO - Cellular componenti
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| PeptideiPRO_0000228824 | 1 – 29 | Potassium channel toxin alpha-KTx 20.1Add BLAST | 29 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Disulfide bondi | 2 ↔ 20 | By similarity | ||
| Disulfide bondi | 7 ↔ 24 | By similarity | ||
| Disulfide bondi | 11 ↔ 26 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.
Family & Domainsi
Sequence similaritiesi
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 20 subfamily.Curated
Sequencei
Sequence statusi: Complete.
Mass spectrometryi
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
Entry informationi
| Entry namei | KA201_TITTR | |
| Accessioni | P0C183Primary (citable) accession number: P0C183 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
| Last sequence update: | March 21, 2006 | |
| Last modified: | May 10, 2017 | |
| This is version 25 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Animal Toxin Annotation Program | |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families
