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P0C183

- KA201_TITTR

UniProt

P0C183 - KA201_TITTR

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Protein
Potassium channel toxin alpha-KTx 20.1
Gene
N/A
Organism
Tityus trivittatus (Argentinean scorpion)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Reduces potassium currents through Kv1.2/KCNA2 and Kv1.3/KCNA3 voltage-gated potassium channels.1 Publication

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 20.1
Alternative name(s):
Toxin Tt28
OrganismiTityus trivittatus (Argentinean scorpion)
Taxonomic identifieri369776 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 2929Potassium channel toxin alpha-KTx 20.1
PRO_0000228824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi2 ↔ 20 By similarity
Disulfide bondi7 ↔ 24 By similarity
Disulfide bondi11 ↔ 26 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Sequence similaritiesi

Sequencei

Sequence statusi: Complete.

P0C183-1 [UniParc]FASTAAdd to Basket

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GCTPEYCSMW CKVKVSQNYC VKNCKCPGR                          29
Length:29
Mass (Da):3,316
Last modified:March 21, 2006 - v1
Checksum:i13C6D9D2E7A25CD0
GO

Mass spectrometryi

Molecular mass is 3310.3 Da from positions 1 - 29. Determined by ESI. 1 Publication

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "A novel toxin from the venom of the scorpion Tityus trivittatus, is the first member of a new alpha-KTX subfamily."
    Abdel-Mottaleb Y., Coronas F.V., de Roodt A.R., Possani L.D., Tytgat J.
    FEBS Lett. 580:592-596(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY.
    Tissue: Venom.

Entry informationi

Entry nameiKA201_TITTR
AccessioniPrimary (citable) accession number: P0C183
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: February 19, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

Has no effect on Kv1.1/KCNA1, Kv1.4/KCNA4, Kv1.5/KCNA5, shaker IR or Kv11.1/KCNH2 channels (1 Publication).

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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