P0C183 (KA201_TITTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Potassium channel toxin alpha-KTx 20.1 Alternative name(s): Toxin Tt28
Organism	Tityus trivittatus (Argentinean scorpion)
Taxonomic identifier	369776 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Tityus

Protein attributes

Sequence length	29 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Reduces potassium currents through Kv1.2/KCNA2 and Kv1.3/KCNA3 voltage-gated potassium channels. Ref.1
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Miscellaneous	Has no effect on Kv1.1/KCNA1, Kv1.4/KCNA4, Kv1.5/KCNA5, shaker IR or Kv11.1/KCNH2 channels (Ref.1).
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 20 subfamily.
Mass spectrometry	Molecular mass is 3310.3 Da from positions 1 - 29. Determined by ESI. Ref.1

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Ion channel impairing toxin Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 29	29	Potassium channel toxin alpha-KTx 20.1		PRO_0000228824
Amino acid modifications
	Disulfide bond	2 ↔ 20		By similarity
	Disulfide bond	7 ↔ 24		By similarity
	Disulfide bond	11 ↔ 26		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C183 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 13C6D9D2E7A25CD0	FASTA	29	3,316
	10 20 GCTPEYCSMW CKVKVSQNYC VKNCKCPGR

References

[1]

"A novel toxin from the venom of the scorpion Tityus trivittatus, is the first member of a new alpha-KTX subfamily." Abdel-Mottaleb Y., Coronas F.V., de Roodt A.R., Possani L.D., Tytgat J. FEBS Lett. 580:592-596(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY. Tissue: Venom.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
PROSITE	PS01138. SCORP_SHORT_TOXIN. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KA201_TITTR

Accession

Primary (citable) accession number: P0C183

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	March 6, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program