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P0C183 (KA201_TITTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 20.1
Alternative name(s):
Toxin Tt28
OrganismTityus trivittatus (Argentinean scorpion)
Taxonomic identifier369776 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Protein attributes

Sequence length29 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Reduces potassium currents through Kv1.2/KCNA2 and Kv1.3/KCNA3 voltage-gated potassium channels. Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Miscellaneous

Has no effect on Kv1.1/KCNA1, Kv1.4/KCNA4, Kv1.5/KCNA5, shaker IR or Kv11.1/KCNH2 channels (Ref.1).

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 20 subfamily.

Mass spectrometry

Molecular mass is 3310.3 Da from positions 1 - 29. Determined by ESI. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 2929Potassium channel toxin alpha-KTx 20.1
PRO_0000228824

Amino acid modifications

Disulfide bond2 ↔ 20 By similarity
Disulfide bond7 ↔ 24 By similarity
Disulfide bond11 ↔ 26 By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C183 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 13C6D9D2E7A25CD0

FASTA293,316
        10         20 
GCTPEYCSMW CKVKVSQNYC VKNCKCPGR 

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References

[1]"A novel toxin from the venom of the scorpion Tityus trivittatus, is the first member of a new alpha-KTX subfamily."
Abdel-Mottaleb Y., Coronas F.V., de Roodt A.R., Possani L.D., Tytgat J.
FEBS Lett. 580:592-596(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY.
Tissue: Venom.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameKA201_TITTR
AccessionPrimary (citable) accession number: P0C183
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: February 19, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries