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P0C183

- KA201_TITTR

UniProt

P0C183 - KA201_TITTR

Protein

Potassium channel toxin alpha-KTx 20.1

Gene
N/A
Organism
Tityus trivittatus (Argentinean scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Reduces potassium currents through Kv1.2/KCNA2 and Kv1.3/KCNA3 voltage-gated potassium channels.1 Publication

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin alpha-KTx 20.1
    Alternative name(s):
    Toxin Tt28
    OrganismiTityus trivittatus (Argentinean scorpion)
    Taxonomic identifieri369776 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 2929Potassium channel toxin alpha-KTx 20.1PRO_0000228824Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi2 ↔ 20By similarity
    Disulfide bondi7 ↔ 24By similarity
    Disulfide bondi11 ↔ 26By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Family & Domainsi

    Sequence similaritiesi

    Sequencei

    Sequence statusi: Complete.

    P0C183-1 [UniParc]FASTAAdd to Basket

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    GCTPEYCSMW CKVKVSQNYC VKNCKCPGR                          29
    Length:29
    Mass (Da):3,316
    Last modified:March 21, 2006 - v1
    Checksum:i13C6D9D2E7A25CD0
    GO

    Mass spectrometryi

    Molecular mass is 3310.3 Da from positions 1 - 29. Determined by ESI. 1 Publication

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "A novel toxin from the venom of the scorpion Tityus trivittatus, is the first member of a new alpha-KTX subfamily."
      Abdel-Mottaleb Y., Coronas F.V., de Roodt A.R., Possani L.D., Tytgat J.
      FEBS Lett. 580:592-596(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY.
      Tissue: Venom.

    Entry informationi

    Entry nameiKA201_TITTR
    AccessioniPrimary (citable) accession number: P0C183
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Miscellaneous

    Has no effect on Kv1.1/KCNA1, Kv1.4/KCNA4, Kv1.5/KCNA5, shaker IR or Kv11.1/KCNH2 channels.1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3