P0C182 (KAX1B_CENNO) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 21.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Potassium channel toxin alpha-KTx 1.11 Alternative name(s): Slotoxin Short name=SloTx |
| Organism | Centruroides noxius (Mexican scorpion) |
| Taxonomic identifier | 6878 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Centruroides |
Protein attributes
| Sequence length | 37 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Reversibly blocks the high conductance calcium-activated potassium channels composed of only alpha subunits (KCNMA1 = Slo1). Unreversibly blocks the high conductance calcium-activated potassium channels composed of alpha and beta1 subunits (KCNMA1 and KCNMB1). Unreversibly and weakly blocks the high conductance calcium-activated potassium channels composed of alpha and beta4 (KCNMA1 and KCNMB4). Ref.1 |
| Subcellular location | |
| Tissue specificity | Expressed by the venom gland. |
| Miscellaneous | No activity has been observed on other potassium channels such as slo, KCNA1, KCNH2, KCNJ12, Shaker-IR, and voltage-independent/calcium-activated SK1, SK2 and SK3 (Ref.1). |
| Sequence similarities | Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 1 subfamily. |
| Mass spectrometry |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Molecular function | Ionic channel inhibitor Neurotoxin Potassium channel inhibitor Toxin |
| PTM | Disulfide bond |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | pathogenesis Inferred from electronic annotation. Source: InterPro |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 37 | 37 | Potassium channel toxin alpha-KTx 1.11 | PRO_0000228823 | |||||||
Sites | |||||||||||
| Site | 27 | 1 | Basic residue of the functional dyad By similarity | ||||||||
| Site | 36 | 1 | Aromatic residue of the functional dyad By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 7 ↔ 28 | By similarity | |||||||||
| Disulfide bond | 13 ↔ 33 | By similarity | |||||||||
| Disulfide bond | 17 ↔ 35 | By similarity | |||||||||
Sequences
References
| [1] | "Slotoxin, alphaKTx1.11, a new scorpion peptide blocker of MaxiK channels that differentiates between alpha and alpha+beta (beta1 or beta4) complexes." Garcia-Valdes J., Zamudio F.Z., Toro L., Possani L.D. FEBS Lett. 505:369-373(2001) [PubMed: 11576530] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY. Tissue: Venom. |
| [2] | Erratum Garcia-Valdes J., Zamudio F.Z., Toro L., Possani L.D. FEBS Lett. 507:122-122(2001) |
Cross-references
3D structure databases | |
|---|---|
| ProteinModelPortal | P0C182. |
| SMR | P0C182. Positions 1-37. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| InterPro | IPR001947. Scorpion_toxinS. [Graphical view] |
| Pfam | PF00451. Toxin_2. 1 hit. [Graphical view] |
| PRINTS | PR00286. CHARYBDTOXIN. |
| ProDom | PD003586. Scorpion_toxinS. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS01138. SCORP_SHORT_TOXIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KAX1B_CENNO | ||||||||
| Accession | Primary (citable) accession number: P0C182 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Animal Toxin Annotation Program | ||||||||
Relevant documents
| Scorpion potassium channel toxins Nomenclature of scorpion potassium channel toxins and list of entries |
| SIMILARITY comments Index of protein domains and families |

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