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Reviewed, UniProtKB/Swiss-Prot P0C182 (KAX1B_CENNO)

Last modified June 16, 2009. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Potassium channel toxin alpha-KTx 1.11
Alternative name(s):
    Slotoxin
      Short name=SloTx
OrganismCentruroides noxius (Mexican scorpion)
Taxonomic identifier6878 [NCBI]
Taxonomic lineageEukaryotaMetazoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeCentruroides

Protein attributes

Sequence length37 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Reversibly blocks the high conductance calcium-activated potassium channels composed of only alpha subunits (KCNMA1 = Slo1). Unreversibly blocks the high conductance calcium-activated potassium channels composed of alpha and beta1 subunits (KCNMA1 and KCNMB1). Unreversibly and weakly blocks the high conductance calcium-activated potassium channels composed of alpha and beta4 (KCNMA1 and KCNMB4). No activity on other potassium channels such as slo, KCNA1, KCNH2, KCNJ12, Shaker-IR, nor voltage-independent/calcium-activated SK1, SK2 and SK3. Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 1 subfamily.

Mass spectrometry

Molecular mass is 4082.82 Da from positions 1 - 37. Ref.1

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionIonic channel inhibitor
Neurotoxin
Potassium channel inhibitor
Toxin
   PTMDisulfide bond
Pyrrolidone carboxylic acid
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionpotassium channel inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3737Potassium channel toxin alpha-KTx 1.11
PRO_0000228823

Amino acid modifications

Disulfide bond7 ↔ 28 By similarity
Disulfide bond13 ↔ 33 By similarity
Disulfide bond17 ↔ 35 By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C182-1 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 87352585F8F85028

FASTA374,092
        10         20         30 
TFIDVDCTVS KECWAPCKAA FGVDRGKCMG KKCKCYV 

« Hide

References

[1]"Slotoxin, alphaKTx1.11, a new scorpion peptide blocker of MaxiK channels that differentiates between alpha and alpha+beta (beta1 or beta4) complexes."
Garcia-Valdes J., Zamudio F.Z., Toro L., Possani L.D.
FEBS Lett. 505:369-373(2001) [PubMed: 11576530] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY.
Tissue: Venom.
[2]Erratum
Garcia-Valdes J., Zamudio F.Z., Toro L., Possani L.D.
FEBS Lett. 507:122-122(2001)

Cross-references

3D structure databases

ModBaseSearch...

Family and domain databases

InterProIPR001947. Scorpion_toxinS.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
PRINTSPR00286. CHARYBDTOXIN.
ProDomPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKAX1B_CENNO
AccessionPrimary (citable) accession number: P0C182
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: June 16, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectTox-Prot (Toxin Annotation Project)

Relevant documents

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents