Potassium channel toxin epsilon-KTx 1.1

Functionⁱ

Potassium channel blocker. At 3 µM, this toxin blocks voltage-independently voltage-gated potassium channels rKv1.2/KCNA2 (25%), hKv1.3/KCNA3 (27%), rKv4.2/KCND2 (25%), Kv10.1/KCNH1/EAG1 (15%), Kv11/hERG (12%), and Shaker-IR (10%). On hKv1.3/KCNA3, the IC₅₀ is 17.1 +-3.3 µM.1 Publication

Miscellaneous

Does not block all sodium channels tested and several potassium channels. Does not block the following voltage-gated potassium channels: rKv1.1/KCNA1, rKv1.1/KCNA1, rKv1.5/KCNA5, rKv1.6/KCNA6, rKv2.1/KCNB1, hKv3.1/KCNC1, and Kv7.2/KCNQ2. Does not block the following voltage-gated sodium channels: rNav1.1/SCN1A, rNav1.4/SCN4A, hNav1.5/SCN5A, mNav1.6/SCN8A, and DmNav1/para.1 Publication

GO - Biological processⁱ

defense response Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Ion channel impairing toxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Molecular function

Ion channel impairing toxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Potassium channel toxin epsilon-KTx 1.11 Publication Alternative name(s): Ts111 Publication TsPep11 Publication
Organismⁱ	Tityus serrulatus (Brazilian scorpion)
Taxonomic identifierⁱ	6887 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Tityus

Subcellular locationⁱ

Secreted
2 Publications
Manual assertion based on experiment inⁱ
- Ref.1
  "Novel structural class of four disulfide-bridged peptides from Tityus serrulatus venom."
  Pimenta A.M.C., Legros C., Almeida F.M., Mansuelle P., De Lima M.E., Bougis P.E., Martin-Eauclaire M.-F.
  Biochem. Biophys. Res. Commun. 301:1086-1092(2003) [PubMed] [Europe PMC] [Abstract]
  Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY, SUBCELLULAR LOCATION.
- Ref.2
  "Structural and functional elucidation of peptide Ts11 shows evidence of a novel subfamily of scorpion venom toxins."
  Cremonez C.M., Maiti M., Peigneur S., Cassoli J.S., Dutra A.A., Waelkens E., Lescrinier E., Herdewijn P., de Lima M.E., Pimenta A.M., Arantes E.C., Tytgat J.
  Toxins 8:1-14(2016) [PubMed] [Europe PMC] [Abstract]
  Cited for: PARTIAL PROTEIN SEQUENCE, FUNCTION, STRUCTURE BY NMR, DISULFIDE BOND, MASS SPECTROMETRY, NOMENCLATURE.

GO - Cellular componentⁱ

extracellular region Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
PeptideⁱPRO_0000227819	1 – 29	Potassium channel toxin epsilon-KTx 1.1Add BLAST		29

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	4 ↔ 12	1 Publication
Disulfide bondⁱ	7 ↔ 28	1 Publication
Disulfide bondⁱ	11 ↔ 21	1 Publication
Disulfide bondⁱ	16 ↔ 26	1 Publication

Keywords - PTMⁱ

Disulfide bond

Expressionⁱ

Tissue specificityⁱ

Expressed by the venom gland.Curated

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	5 – 9	Combined sources	5
Beta strandⁱ	12 – 14	Combined sources	3
Beta strandⁱ	17 – 19	Combined sources	3
Beta strandⁱ	23 – 26	Combined sources	4

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2MSF	NMR	-	A	1-29	[»]
SMRⁱ	P0C174.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domainⁱ

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.1 Publication

Is completely devoid of the classical secondary structure elements (alpha-helix and/or beta-strand).1 Publication

Sequence similaritiesⁱ

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Epsilon-KTx 01 subfamily.Curated

Keywords - Domainⁱ

Knottin

Family and domain databases

InterProⁱ	View protein in InterPro IPR003614. Scorpion_toxin-like.
SUPFAMⁱ	SSF57095. SSF57095. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P0C174-1 [UniParc]FASTA Add to basket

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        10         20 
KPKCGLCRYR CCSGGCSSGK CVNGACDCS

Length:29

Mass (Da):2,946

Last modified:March 21, 2006 - v1

Checksum:ⁱB8F453A8BC520EB0

GO

Mass spectrometryⁱ

Molecular mass is 2938.92 Da from positions 1 - 29. Determined by MALDI. 1 Publication

Molecular mass is 2938.2 Da from positions 1 - 29. Determined by MALDI. 1 Publication

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Web resourcesⁱ

Biological Magnetic Resonance Data Bank

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2MSF	NMR	-	A	1-29	[»]
SMRⁱ	P0C174.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Family and domain databases

InterProⁱ	View protein in InterPro IPR003614. Scorpion_toxin-like.
SUPFAMⁱ	SSF57095. SSF57095. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KEX11_TITSE
Accessionⁱ	P0C174Primary (citable) accession number: P0C174
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
	Last sequence update:	March 21, 2006
	Last modified:	November 30, 2016
	This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Animal Toxin Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries
SIMILARITY comments
Index of protein domains and families

UniProtKB - P0C174 (KEX11_TITSE)

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Functionⁱ

Miscellaneous

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Expressionⁱ

Tissue specificityⁱ

Structureⁱ

Secondary structure

3D structure databases

Family & Domainsⁱ

Domainⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Family and domain databases

Sequenceⁱ

Mass spectrometryⁱ

Similar proteinsⁱ

Cross-referencesⁱ

Web resourcesⁱ

3D structure databases

Protocols and materials databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0C174 (KEX11_TITSE)

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Potassium channel toxin epsilon-KTx 1.1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

3D structure databases

Protocols and materials databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Mass spectrometryⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ