P0C173 (KA161_MESTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Potassium channel toxin alpha-KTx 16.1 Alternative name(s): Alpha-KTx 1.8 Tamulotoxin Short name=TmTX
Organism	Mesobuthus tamulus (Eastern Indian scorpion) (Buthus tamulus)
Taxonomic identifier	34647 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Mesobuthus

Protein attributes

Sequence length	36 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Blocks calcium-activated potassium channels By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 16 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Ion channel impairing toxin Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 36	36	Potassium channel toxin alpha-KTx 16.1		PRO_0000227816
Sites
	Site	27	1	Basic residue of the functional dyad By similarity
	Site	36	1	Aromatic residue of the functional dyad By similarity
Amino acid modifications
	Disulfide bond	7 ↔ 28		By similarity
	Disulfide bond	13 ↔ 33		By similarity
	Disulfide bond	17 ↔ 35		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C173 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: D0F40011658569F6	FASTA	36	4,213
	10 20 30 DLIDVKCISS QECWIACKKV TGRFEGKCQN RQCRCY

References

[1]

"Tamulotoxin, a novel member of potassium channel active short toxins from the venom of the indian red scorpion Buthus tamulus." Escoubas P., Romi-Lebrun R., Lebrun B., Herrmann R., Moskowitz H., Rajendra W., Hammock B., Nakajima T. Toxicon 35:806-806(1997) Cited for: PROTEIN SEQUENCE, SYNTHESIS. Tissue: Venom.

Cross-references

3D structure databases
ProteinModelPortal	P0C173.
SMR	P0C173. Positions 1-36.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.30.10. 1 hit.
InterPro	IPR003614. Scorpion_toxin-like. IPR001947. Scorpion_toxinS_K_inh. [Graphical view]
Pfam	PF00451. Toxin_2. 1 hit. [Graphical view]
ProDom	PD003586. Scorpion_toxinS. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF57095. SSF57095. 1 hit.
PROSITE	PS01138. SCORP_SHORT_TOXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KA161_MESTA

Accession

Primary (citable) accession number: P0C173

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	May 1, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program