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P0C173

- KA161_MESTA

UniProt

P0C173 - KA161_MESTA

Protein

Potassium channel toxin alpha-KTx 16.1

Gene
N/A
Organism
Mesobuthus tamulus (Eastern Indian scorpion) (Buthus tamulus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Blocks calcium-activated potassium channels.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei27 – 271Basic residue of the functional dyadBy similarity
    Sitei36 – 361Aromatic residue of the functional dyadBy similarity

    GO - Molecular functioni

    1. ion channel inhibitor activity Source: InterPro

    GO - Biological processi

    1. defense response Source: InterPro
    2. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin alpha-KTx 16.1
    Alternative name(s):
    Alpha-KTx 1.8
    Tamulotoxin
    Short name:
    TmTX
    OrganismiMesobuthus tamulus (Eastern Indian scorpion) (Buthus tamulus)
    Taxonomic identifieri34647 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeMesobuthus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3636Potassium channel toxin alpha-KTx 16.1PRO_0000227816Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi7 ↔ 28By similarity
    Disulfide bondi13 ↔ 33By similarity
    Disulfide bondi17 ↔ 35By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C173.
    SMRiP0C173. Positions 1-36.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.30.30.10. 1 hit.
    InterProiIPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view]
    PfamiPF00451. Toxin_2. 1 hit.
    [Graphical view]
    ProDomiPD003586. Scorpion_toxinS. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF57095. SSF57095. 1 hit.
    PROSITEiPS01138. SCORP_SHORT_TOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C173-1 [UniParc]FASTAAdd to Basket

    « Hide

    DLIDVKCISS QECWIACKKV TGRFEGKCQN RQCRCY                  36
    Length:36
    Mass (Da):4,213
    Last modified:March 21, 2006 - v1
    Checksum:iD0F40011658569F6
    GO

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P0C173.
    SMRi P0C173. Positions 1-36.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.30.10. 1 hit.
    InterProi IPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view ]
    Pfami PF00451. Toxin_2. 1 hit.
    [Graphical view ]
    ProDomi PD003586. Scorpion_toxinS. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF57095. SSF57095. 1 hit.
    PROSITEi PS01138. SCORP_SHORT_TOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tamulotoxin, a novel member of potassium channel active short toxins from the venom of the indian red scorpion Buthus tamulus."
      Escoubas P., Romi-Lebrun R., Lebrun B., Herrmann R., Moskowitz H., Rajendra W., Hammock B., Nakajima T.
      Toxicon 35:806-806(1997)
      Cited for: PROTEIN SEQUENCE, SYNTHESIS.
      Tissue: Venom.

    Entry informationi

    Entry nameiKA161_MESTA
    AccessioniPrimary (citable) accession number: P0C173
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3