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P0C168

- KA122_TITTR

UniProt

P0C168 - KA122_TITTR

Protein

Potassium channel toxin alpha-KTx 12.2

Gene
N/A
Organism
Tityus trivittatus (Argentinean scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Inhibits high conductance calcium-activated potassium channels By similarity. Reversibly inhibits Shaker B potassium channels.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei30 – 301Basic residue of the functional dyadBy similarity
    Sitei39 – 391Aromatic residue of the functional dyadBy similarity

    GO - Molecular functioni

    1. ion channel inhibitor activity Source: InterPro

    GO - Biological processi

    1. defense response Source: InterPro
    2. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin alpha-KTx 12.2
    Alternative name(s):
    Butantoxin
    Short name:
    BuTX
    TtBut
    OrganismiTityus trivittatus (Argentinean scorpion)
    Taxonomic identifieri369776 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4040Potassium channel toxin alpha-KTx 12.2PRO_0000226996Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi2 ↔ 5
    Disulfide bondi10 ↔ 31
    Disulfide bondi16 ↔ 36
    Disulfide bondi20 ↔ 38

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C168.
    SMRiP0C168. Positions 1-40.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.30.30.10. 1 hit.
    InterProiIPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view]
    PfamiPF00451. Toxin_2. 1 hit.
    [Graphical view]
    PRINTSiPR00286. CHARYBDTOXIN.
    ProDomiPD003586. Scorpion_toxinS. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF57095. SSF57095. 1 hit.
    PROSITEiPS01138. SCORP_SHORT_TOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C168-1 [UniParc]FASTAAdd to Basket

    « Hide

    WCSTCLDLAC GASRECYDPC FKAFGRAHGK CMNNKCRCYT              40
    Length:40
    Mass (Da):4,514
    Last modified:March 7, 2006 - v1
    Checksum:i79C47786312FC1BD
    GO

    Mass spectrometryi

    Molecular mass is 4507.0 Da from positions 1 - 40. Determined by ESI. 1 Publication

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P0C168.
    SMRi P0C168. Positions 1-40.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.30.10. 1 hit.
    InterProi IPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view ]
    Pfami PF00451. Toxin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00286. CHARYBDTOXIN.
    ProDomi PD003586. Scorpion_toxinS. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF57095. SSF57095. 1 hit.
    PROSITEi PS01138. SCORP_SHORT_TOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Disulfide bridges and blockage of Shaker B K(+)-channels by another butantoxin peptide purified from the Argentinean scorpion Tityus trivittatus."
      Coronas F.V., de Roodt A.R., Olamendi-Portugal T., Zamudio F.Z., Batista C.V.F., Gomez-Lagunas F., Possani L.D.
      Toxicon 41:173-179(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, DISULFIDE BONDS, MASS SPECTROMETRY.
    2. Cited for: STRUCTURE BY NMR, DISULFIDE BONDS, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiKA122_TITTR
    AccessioniPrimary (citable) accession number: P0C168
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Miscellaneous

    The N-terminal C2-C5 disulfide bridge unique to this toxin does not appear to confer stability to the protein.

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3