P0C167 (KAX14_CENLM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Potassium channel toxin alpha-KTx 1.4 Alternative name(s): Limbatotoxin Short name=LbTx Limbatustoxin
Organism	Centruroides limbatus (Bark scorpion)
Taxonomic identifier	244936 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Centruroides

Protein attributes

Sequence length	37 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Blocks selectively the high conductance calcium-activated (maxi-K) potassium channels By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 1 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Ion channel impairing toxin Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	defense response Inferred from electronic annotation. Source: InterPro pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 37	37	Potassium channel toxin alpha-KTx 1.4		PRO_0000226964
Sites
	Site	27	1	Basic residue of the functional dyad By similarity
	Site	36	1	Aromatic residue of the functional dyad By similarity
Amino acid modifications
	Disulfide bond	7 ↔ 28		By similarity
	Disulfide bond	13 ↔ 33		By similarity
	Disulfide bond	17 ↔ 35		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C167 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: D24C3592CBA917A3	FASTA	37	4,042
	10 20 30 VFIDVSCSVS KECWAPCKAA VGTDRGKCMG KKCRCYX

References

[1]	"Peptides and genes coding for scorpion toxins that affect ion-channels." Novick J., Leonard R.J., King V.F., Schmalhofer W., Kaczororowski G.J., Garcia M.L. Biophys. J. 59:78A-78A(1991) Cited for: PROTEIN SEQUENCE. Tissue: Venom.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.30.10. 1 hit.
InterPro	IPR003614. Scorpion_toxin-like. IPR001947. Scorpion_toxinS_K_inh. [Graphical view]
Pfam	PF00451. Toxin_2. 1 hit. [Graphical view]
PRINTS	PR00286. CHARYBDTOXIN.
ProDom	PD003586. Scorpion_toxinS. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF57095. SSF57095. 1 hit.
PROSITE	PS01138. SCORP_SHORT_TOXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAX14_CENLM

Accession

Primary (citable) accession number: P0C167

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	March 7, 2006
Last modified:	May 29, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program