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P0C166

- KAX6C_ANUPH

UniProt

P0C166 - KAX6C_ANUPH

Protein

Potassium channel toxin alpha-KTx 6.12

Gene
N/A
Organism
Anuroctonus phaiodactylus (Mafia scorpion)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    High affinity blocker of Kv1.3/KCNA3 channels of human T cells. Blocks Kv1.2/KCNA2 with an order of magnitude smaller than for Kv1.3/KCNA3.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei23 – 231Basic residue of the functional dyadBy similarity
    Sitei32 – 321Aromatic residue of the functional dyadBy similarity

    GO - Molecular functioni

    1. ion channel inhibitor activity Source: InterPro

    GO - Biological processi

    1. defense response Source: InterPro
    2. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin alpha-KTx 6.12
    Alternative name(s):
    Anuroctoxin
    OrganismiAnuroctonus phaiodactylus (Mafia scorpion)
    Taxonomic identifieri246982 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaChactoideaChactidaeUroctoninaeAnuroctonus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3535Potassium channel toxin alpha-KTx 6.12PRO_0000226963Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11Pyrrolidone carboxylic acid
    Disulfide bondi4 ↔ 241 Publication
    Disulfide bondi10 ↔ 291 Publication
    Disulfide bondi14 ↔ 311 Publication
    Disulfide bondi19 ↔ 341 Publication
    Modified residuei35 – 351Lysine amide

    Keywords - PTMi

    Amidation, Disulfide bond, Pyrrolidone carboxylic acid

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP0C166.
    SMRiP0C166. Positions 3-34.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.30.30.10. 1 hit.
    InterProiIPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view]
    PfamiPF00451. Toxin_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF57095. SSF57095. 1 hit.
    PROSITEiPS01138. SCORP_SHORT_TOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C166-1 [UniParc]FASTAAdd to Basket

    « Hide

    QKECTGPQHC TNFCRKNKCT HGKCMNRKCK CFNCK                   35
    Length:35
    Mass (Da):4,109
    Last modified:March 7, 2006 - v1
    Checksum:iB9B8E9CD7E4DA845
    GO

    Mass spectrometryi

    Molecular mass is 4082.8 Da from positions 1 - 35. Determined by ESI. 1 Publication

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P0C166.
    SMRi P0C166. Positions 3-34.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.30.10. 1 hit.
    InterProi IPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view ]
    Pfami PF00451. Toxin_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57095. SSF57095. 1 hit.
    PROSITEi PS01138. SCORP_SHORT_TOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes."
      Bagdany M., Batista C.V.F., Valdez-Cruz N.A., Somodi S., Rodriguez de la Vega R.C., Licea A.F., Varga Z., Gaspar R., Possani L.D., Panyi G.
      Mol. Pharmacol. 67:1034-1044(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, SUBUNIT, DISULFIDE BONDS, MASS SPECTROMETRY.
      Tissue: Venom.

    Entry informationi

    Entry nameiKAX6C_ANUPH
    AccessioniPrimary (citable) accession number: P0C166
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Miscellaneous

    This toxin does not block the calcium-activated KCa3.1/KCNN4 potassium channels, Shaker IR, Kv1.1/KCNA1, and Kv2.1/KCNB1 potassium channels.1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3