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P0C166 (KAX6C_ANUPH) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 6.12
Alternative name(s):
Anuroctoxin
OrganismAnuroctonus phaiodactylus (Mafia scorpion)
Taxonomic identifier246982 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaChactoideaChactidaeUroctoninaeAnuroctonus

Protein attributes

Sequence length35 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

High affinity blocker of Kv1.3/KCNA3 channels of human T cells. Blocks Kv1.2/KCNA2 with an order of magnitude smaller than for Kv1.3/KCNA3. Ref.1

Subunit structure

Monomer. Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Miscellaneous

This toxin does not block the calcium-activated KCa3.1/KCNN4 potassium channels, Shaker IR, Kv1.1/KCNA1, and Kv2.1/KCNB1 potassium channels (Ref.1).

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 6 subfamily.

Mass spectrometry

Molecular mass is 4082.8 Da from positions 1 - 35. Determined by ESI. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3535Potassium channel toxin alpha-KTx 6.12
PRO_0000226963

Sites

Site231Basic residue of the functional dyad By similarity
Site321Aromatic residue of the functional dyad By similarity

Amino acid modifications

Modified residue11Pyrrolidone carboxylic acid
Modified residue351Lysine amide
Disulfide bond4 ↔ 24 Ref.1
Disulfide bond10 ↔ 29 Ref.1
Disulfide bond14 ↔ 31 Ref.1
Disulfide bond19 ↔ 34 Ref.1

Sequences

Sequence LengthMass (Da)Tools
P0C166 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: B9B8E9CD7E4DA845

FASTA354,109
        10         20         30 
QKECTGPQHC TNFCRKNKCT HGKCMNRKCK CFNCK 

« Hide

References

[1]"Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes."
Bagdany M., Batista C.V.F., Valdez-Cruz N.A., Somodi S., Rodriguez de la Vega R.C., Licea A.F., Varga Z., Gaspar R., Possani L.D., Panyi G.
Mol. Pharmacol. 67:1034-1044(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, SUBUNIT, DISULFIDE BONDS, MASS SPECTROMETRY.
Tissue: Venom.

Cross-references

3D structure databases

ProteinModelPortalP0C166.
SMRP0C166. Positions 3-34.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.30.10. 1 hit.
InterProIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
SUPFAMSSF57095. SSF57095. 1 hit.
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKAX6C_ANUPH
AccessionPrimary (citable) accession number: P0C166
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: October 16, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries