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Protein

Potassium channel toxin alpha-KTx 6.12

Gene
N/A
Organism
Anuroctonus phaiodactylus (Mafia scorpion)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High affinity blocker of Kv1.3/KCNA3 channels of human T cells. Blocks Kv1.2/KCNA2 with an order of magnitude smaller than for Kv1.3/KCNA3.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei23 – 231Basic residue of the functional dyadBy similarity
Sitei32 – 321Aromatic residue of the functional dyadBy similarity

GO - Molecular functioni

  1. ion channel inhibitor activity Source: InterPro

GO - Biological processi

  1. defense response Source: InterPro
  2. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 6.12
Alternative name(s):
Anuroctoxin
OrganismiAnuroctonus phaiodactylus (Mafia scorpion)
Taxonomic identifieri246982 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaChactoideaChactidaeUroctoninaeAnuroctonus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3535Potassium channel toxin alpha-KTx 6.12PRO_0000226963Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11Pyrrolidone carboxylic acid
Disulfide bondi4 ↔ 241 Publication
Disulfide bondi10 ↔ 291 Publication
Disulfide bondi14 ↔ 311 Publication
Disulfide bondi19 ↔ 341 Publication
Modified residuei35 – 351Lysine amide

Keywords - PTMi

Amidation, Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP0C166.
SMRiP0C166. Positions 3-34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamiPF00451. Toxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C166-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
QKECTGPQHC TNFCRKNKCT HGKCMNRKCK CFNCK
Length:35
Mass (Da):4,109
Last modified:March 7, 2006 - v1
Checksum:iB9B8E9CD7E4DA845
GO

Mass spectrometryi

Molecular mass is 4082.8 Da from positions 1 - 35. Determined by ESI. 1 Publication

Cross-referencesi

3D structure databases

ProteinModelPortaliP0C166.
SMRiP0C166. Positions 3-34.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamiPF00451. Toxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes."
    Bagdany M., Batista C.V.F., Valdez-Cruz N.A., Somodi S., Rodriguez de la Vega R.C., Licea A.F., Varga Z., Gaspar R., Possani L.D., Panyi G.
    Mol. Pharmacol. 67:1034-1044(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, SUBUNIT, DISULFIDE BONDS, MASS SPECTROMETRY.
    Tissue: Venom.

Entry informationi

Entry nameiKAX6C_ANUPH
AccessioniPrimary (citable) accession number: P0C166
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: January 7, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

This toxin does not block the calcium-activated KCa3.1/KCNN4 potassium channels, Shaker IR, Kv1.1/KCNA1, and Kv2.1/KCNB1 potassium channels.1 Publication

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.