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Protein

Serine/threonine-protein phosphatase 2A activator 2

Gene

rrd2

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg2+ by dissociating the inactive form from the complex (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A activator 2 (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase PTPA-2
Short name:
PPIase PTPA-2
Short name:
Rotamase PTPA-2
Phosphotyrosyl phosphatase activator 2
Gene namesi
Name:rrd2
ORF Names:AN10111
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VIII
  • UP000005890 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:AN10111.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Serine/threonine-protein phosphatase 2A activator 2PRO_0000226113Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0C153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTPA-type PPIase family.Curated

Phylogenomic databases

HOGENOMiHOG000205736.
InParanoidiP0C153.
OMAiMQHFYFG.
OrthoDBiEOG092C3CMG.

Family and domain databases

InterProiIPR004327. Phstyr_phstse_ac.
[Graphical view]
PANTHERiPTHR10012. PTHR10012. 1 hit.
PfamiPF03095. PTPA. 1 hit.
[Graphical view]
PIRSFiPIRSF016325. Phstyr_phstse_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNTNPSPK PKIDLSQKLS ELRAARAKTQ SPREPAPVTP PLSKPPDLSS
60 70 80 90 100
HSYSRPVRRI LSKNDHETFL SSSTYTLVLA FIFGLSDSVR GRAAPDANAE
110 120 130 140 150
PGYSPKISKI LSVVDNIRTL VESHPSIDQG GSRFGNPAFR DLFDDVAAQS
160 170 180 190 200
PAWLRDILGI EDAAAVNEIS TYLIHSLGSR DRLDYGSGHE LNFMMWLLCL
210 220 230 240 250
RQLGLFSEPD FEAIVFHVYV RYMRLMREVQ STYYLEPAGS HGVWGLDDYH
260 270 280 290 300
FLPFLFGAAQ LVGHPYITPL AIHNTAILDE EGDRYLYLDQ VRWVDSVKTV
310 320 330 340 350
KGLRWHSPML DDISGAKNWT KIESGMKKMF VKEVLGKLPI MQHFLFGSLL
360 370 380 390 400
PAEPGMGEGE AEEEGEHTHA HGHSHVHDHS QQLDWFGDCC GIKVPSTVAA
410 420
GQEMRKRMGG GSSLRPIPFD
Length:420
Mass (Da):46,790
Last modified:March 7, 2006 - v1
Checksum:i04357E010DB70FFE
GO

Sequence cautioni

The sequence EAA65455 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene AN0679 has been split into 2 genes: AN10108 and AN10111.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000010 Genomic DNA. Translation: EAA65455.1. Sequence problems.
BN001308 Genomic DNA. Translation: CBF89002.1.

Genome annotation databases

EnsemblFungiiCADANIAT00001994; CADANIAP00001994; CADANIAG00001994.
EAA65455; EAA65455; AN0679.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000010 Genomic DNA. Translation: EAA65455.1. Sequence problems.
BN001308 Genomic DNA. Translation: CBF89002.1.

3D structure databases

ProteinModelPortaliP0C153.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00001994; CADANIAP00001994; CADANIAG00001994.
EAA65455; EAA65455; AN0679.2.

Organism-specific databases

EuPathDBiFungiDB:AN10111.

Phylogenomic databases

HOGENOMiHOG000205736.
InParanoidiP0C153.
OMAiMQHFYFG.
OrthoDBiEOG092C3CMG.

Family and domain databases

InterProiIPR004327. Phstyr_phstse_ac.
[Graphical view]
PANTHERiPTHR10012. PTHR10012. 1 hit.
PfamiPF03095. PTPA. 1 hit.
[Graphical view]
PIRSFiPIRSF016325. Phstyr_phstse_ac. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPTPA2_EMENI
AccessioniPrimary (citable) accession number: P0C153
Secondary accession number(s): C8VRR6, Q5BFK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.