Reviewed, UniProtKB/Swiss-Prot P0C145 (UREE1_BRUA2)

Names and origin

Protein names

Recommended name:
    Urease accessory protein ureE 1

Gene names

Name:	ureE1
Ordered Locus Names:	BAB1_0301

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly By similarity. Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral. Ref.1
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ureE family.

Ontologies

Keywords
Biological process	Nickel insertion Virulence
Cellular component	Cytoplasm
Ligand	Nickel
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	enzyme active site formation Inferred from electronic annotation. Source: InterPro pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW protein complex assembly Inferred from electronic annotation. Source: InterPro protein folding Inferred from electronic annotation. Source: InterPro urea metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nickel ion binding Inferred from electronic annotation. Source: HAMAP unfolded protein binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 171	171	Urease accessory protein ureE 1 HAMAP MF_00822		PRO_0000223405

Sequences

	Sequence		Length	Mass (Da)
	P0C145-1 [UniParc]. Last modified February 21, 2006. Version 1. Checksum: BE6064EE8CF2D21E	FASTA	171	19,492
	10 20 30 40 50 60 MFRAIAIIRA HEVIDAVPAS HIVLERDERH LRRKAITLEN GEKILADFAE PVVLEHGDRL 70 80 90 100 110 120 VLDDGREIEI RAASEELYEI RGRDPRHIAE LAWHIGNRHL AAQIETDHIF ILRDHVIRVM 130 140 150 160 170 LEGLGATVTD VVAIFSPLRG AYSGGHQHHH GHDHDHGHHG HDHDHHHPDH E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the urease operon of Brucella abortus and assessment of its role in virulence of the bacterium." Sangari F.J., Seoane A., Rodriguez M.C., Aguero J., Garcia Lobo J.M. Infect. Immun. 75:774-780(2007) [PubMed: 17101645] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION OF ROLE IN VIRULENCE.
[2]	"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF361941 Genomic DNA. Translation: AAK51070.1. AM040264 Genomic DNA. Translation: CAJ10257.1.
PIR	AE3458.
RefSeq	YP_413772.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P0C145.
Genome annotation databases
GeneID	3787079.
GenomeReviews	Gene locus BAB1_0301 in contig AM040264_GR.
KEGG	bmf:BAB1_0301.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG635302.
OMA	DARCKSR.
Enzyme and pathway databases
BioCyc	BMEL359391:BAB1_0301-MON.
Family and domain databases
HAMAP	MF_00822. [Tree]
InterPro	IPR012406. Ureas_acces_UreE. IPR007864. UreE_C. IPR004029. UreE_N. [Graphical view]
Gene3D	G3DSA:3.30.70.790. UreE_C. 1 hit.
Pfam	PF05194. UreE_C. 1 hit. PF02814. UreE_N. 1 hit. [Graphical view]
PIRSF	PIRSF036402. Ureas_acces_UreE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UREE1_BRUA2

Accession

Primary (citable) accession number: P0C145
Secondary accession number(s): Q2YPD4, Q57F84, Q93T80

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	February 21, 2006
Last modified:	December 15, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)