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P0C116

- MTB1_BRUAB

UniProt

P0C116 - MTB1_BRUAB

Protein

Modification methylase BabI

Gene

ccrM

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. CcrM-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology. Essential for viability By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. N-methyltransferase activity Source: InterPro
    3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-519-MONOMER.

    Protein family/group databases

    REBASEi11024. M.BabAORF513P.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase BabI (EC:2.1.1.72)
    Short name:
    M.BabI
    Alternative name(s):
    Adenine-specific methyltransferase BabI
    DNA methyltransferase CcrM
    M.CcrMI ortholog
    Gene namesi
    Name:ccrM
    Synonyms:babI, babIM
    Ordered Locus Names:BruAb1_0513
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377Modification methylase BabIPRO_0000087985Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262698.BruAb1_0513.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C116.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0863.
    HOGENOMiHOG000125329.
    KOiK13581.
    OMAiFWHFEDG.
    OrthoDBiEOG6FV84T.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF01555. N6_N4_Mtase. 1 hit.
    [Graphical view]
    PRINTSiPR00508. S21N4MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C116-1 [UniParc]FASTAAdd to Basket

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    MSLVRLAHEL PIEAPRTAWL DSIIKGDCVS ALERLPDHSV DVIFADPPYN    50
    LQLGGDLHRP DQSMVSAVDD HWDQFESFQA YDAFTRAWLL ACRRVLKPNG 100
    TIWVIGSYHN IFRVGTQLQD LGFWLLNDIV WRKTNPMPNF RGRRFQNAHE 150
    TLIWASREQK GKGYTFNYEA MKAANDDVQM RSDWLFPICT GSERLKDENG 200
    DKVHPTQKPE ALLARIMMAS SKPGDVILDP FFGSGTTGAV AKRLGRHFVG 250
    IEREQPYIDA ATARINAVEP LGKAELTVMT GKRAEPRVAF TSVMEAGLLR 300
    PGTVLCDERR RFAAIVRADG TLTANGEAGS IHRIGARVQG FDACNGWTFW 350
    HFEENGVLKP IDALRKIIRE QMAAAGA 377
    Length:377
    Mass (Da):42,202
    Last modified:February 7, 2006 - v1
    Checksum:i657C88A25580B39D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX73904.1.
    RefSeqiYP_221265.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX73904; AAX73904; BruAb1_0513.
    GeneIDi3339823.
    KEGGibmb:BruAb1_0513.
    PATRICi17822608. VBIBruAbo15061_0541.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX73904.1 .
    RefSeqi YP_221265.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali P0C116.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_0513.

    Protein family/group databases

    REBASEi 11024. M.BabAORF513P.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX73904 ; AAX73904 ; BruAb1_0513 .
    GeneIDi 3339823.
    KEGGi bmb:BruAb1_0513.
    PATRICi 17822608. VBIBruAbo15061_0541.

    Phylogenomic databases

    eggNOGi COG0863.
    HOGENOMi HOG000125329.
    KOi K13581.
    OMAi FWHFEDG.
    OrthoDBi EOG6FV84T.

    Enzyme and pathway databases

    BioCyci BABO262698:GJC2-519-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF01555. N6_N4_Mtase. 1 hit.
    [Graphical view ]
    PRINTSi PR00508. S21N4MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiMTB1_BRUAB
    AccessioniPrimary (citable) accession number: P0C116
    Secondary accession number(s): O30570, Q57EN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3