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Reviewed, UniProtKB/Swiss-Prot P0C114 (DEGP_BRUAB)

Last modified November 24, 2009. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Probable serine protease do-like
    EC=3.4.21.-
Gene names
Name: degP
Synonyms: htrA
Ordered Locus Names: BruAb1_0630
OrganismBrucella abortus [Complete proteome] [HAMAP]
Taxonomic identifier235 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

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Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Subcellular location

Periplasm Potential.

Sequence similarities

Belongs to the peptidase S1B family.

Contains 2 PDZ (DHR) domains.

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Ontologies

Keywords
   Cellular componentPeriplasm
   DomainRepeat
Signal
   Molecular functionHydrolase
Protease
Serine protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentperiplasmic space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein binding

Inferred from electronic annotation. Source: InterPro

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 513488Probable serine protease do-like
PRO_0000026925

Regions

Domain300 – 39192PDZ 1
Domain414 – 50087PDZ 2
Region125 – 299175Serine protease

Sites

Active site1521Charge relay system Potential
Active site1821Charge relay system Potential
Active site2571Charge relay system Potential

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Sequences

Sequence LengthMass (Da)Tools
P0C114-1 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: DE1CEF1959472806

FASTA51353,483
        10         20         30         40         50         60 
MSRARISNYR KGVAAVALSA ALAGAFVVTG PLGALNEARA EAVHVTPPPQ AGFADLVEKV 

        70         80         90        100        110        120 
RPAVVSVRVK KDVQETSNRG PQFFGPPGFD QLPDGHPLKR FFRDFGMEPR GDSRSDNRRG 

       130        140        150        160        170        180 
KANKPRPGHE RPVAQGSGFV ISEDGYVVTN NHVVSDGDAY TVVLDDGTEL DAKLIGADPR 

       190        200        210        220        230        240 
TDLAVLKINA PKRKFVYVAF GDDNKVRVGD WVVAVGNPFG LGGTVTSGIV SARGRDIGAG 

       250        260        270        280        290        300 
PYDDFIQIDA AVNKGNSGGP AFDLSGEVIG INTAIFSPSG GSVGIAFAIP SSTAKQVVDQ 

       310        320        330        340        350        360 
LIKKGSVERG WIGVQIQPVT KDIAASLGLA EEKGAIVASP QDDGPAAKAG IKAGDVITAV 

       370        380        390        400        410        420 
NGETVQDPRD LARKVANIAP GEKAALTVWR KNKAEEINVT IAAMPNDKGK SGSQSNDNDG 

       430        440        450        460        470        480 
GQGETLDSYG LTVVPSEDGK GVVVTDVDPD SDAADRGIRS GDVIVSVNNQ TVKTAGDINK 

       490        500        510 
AITAAEKSGR KAVLLQLQSN DQSRFVALPI NQE

« Hide

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References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941 / Biovar 1.

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Cross-references

Sequence databases

AE017223 Genomic DNA. Translation: AAX74005.1.
RefSeqYP_221366.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3339359.
GenomeReviewsGene locus BruAb1_0630 in contig AE017223_GR.
KEGGbmb:BruAb1_0630.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP0C114.
OMATRSTITI

Enzyme and pathway databases

BioCycBABO262698:BRUAB1_0630-MON.

Family and domain databases

InterProIPR001478. PDZ/DHR/GLGF.
IPR011782. Pept_S1C_Do.
IPR001254. Peptidase_S1_S6.
IPR001940. Peptidase_S1C.
IPR009003. Ser/Cys_Pept_Trypsin-like.
[Graphical view]
PfamPF00595. PDZ. 2 hits.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00834. PROTEASES2C.
SMARTSM00228. PDZ. 2 hits.
[Graphical view]
TIGRFAMsTIGR02037. degP_htrA_DO. 1 hit.
PROSITEPS50106. PDZ. 2 hits.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDEGP_BRUAB
AccessionPrimary (citable) accession number: P0C114
Secondary accession number(s): P0A3Z6, Q44597, Q57EC9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: November 24, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents