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Protein

Aquaporin Z

Gene

aqpZ

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transport of water across the membrane. Possibly involved in the adaptation to variation in intravacuolar pH or osmolarity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei20Involved in tetramerization or stability of the tetramerBy similarity1
Sitei43Selectivity filterBy similarity1
Sitei172Selectivity filterBy similarity1
Sitei181Selectivity filterBy similarity1
Sitei187Selectivity filterBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin Z
Alternative name(s):
Aquaporin X
Gene namesi
Name:aqpZ
Synonyms:aqpX
Ordered Locus Names:BruAb1_1976
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000540 Componenti: Chromosome I

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 29Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini30 – 33PeriplasmicSequence analysis4
Transmembranei34 – 56Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini57 – 80CytoplasmicSequence analysisAdd BLAST24
Transmembranei81 – 103Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini104 – 126PeriplasmicSequence analysisAdd BLAST23
Transmembranei127 – 149Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini150 – 153CytoplasmicSequence analysis4
Transmembranei154 – 176Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini177 – 202PeriplasmicSequence analysisAdd BLAST26
Transmembranei203 – 225Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini226 – 228CytoplasmicSequence analysis3

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639831 – 228Aquaporin ZAdd BLAST228

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0C112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi63 – 65NPA 13
Motifi184 – 186NPA 23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi92 – 97Poly-Ala6

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000288286.
KOiK06188.
OMAiMPIIGGI.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
HAMAPiMF_01146. Aquaporin_Z. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023743. Aquaporin_Z.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C112-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNKLSAEFF GTFWLVFGGC GSAILAAAFP ELGIGFLGVA LAFGLTVLTM
60 70 80 90 100
AYAVGGISGG HFNPAVSLGL TVAGRLPAKD LIPYWVAQVL GAIAAAAILY
110 120 130 140 150
VIASGKDGFS AGGLASNGYG ELSPGGYSMM AGLLIEIILT AFFIIIILGS
160 170 180 190 200
TSSLAPAGFA PIAIGFGLTL IHLVSIPVTN TSVNPARSTG VALFADRAAL
210 220
SQLWLFWVAP LVGAVIGAII WKGLLGRD
Length:228
Mass (Da):23,145
Last modified:February 7, 2006 - v1
Checksum:i23C64C39E4DD444A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX75280.1.
RefSeqiWP_002967012.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX75280; AAX75280; BruAb1_1976.
GeneIDi3788457.
KEGGibmb:BruAb1_1976.
PATRICi17825793. VBIBruAbo15061_2086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX75280.1.
RefSeqiWP_002967012.1. NC_006932.1.

3D structure databases

ProteinModelPortaliP0C112.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX75280; AAX75280; BruAb1_1976.
GeneIDi3788457.
KEGGibmb:BruAb1_1976.
PATRICi17825793. VBIBruAbo15061_2086.

Phylogenomic databases

HOGENOMiHOG000288286.
KOiK06188.
OMAiMPIIGGI.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
HAMAPiMF_01146. Aquaporin_Z. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023743. Aquaporin_Z.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAQPZ_BRUAB
AccessioniPrimary (citable) accession number: P0C112
Secondary accession number(s): Q57AQ4, Q9LA79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.