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P0C112 (AQPZ_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aquaporin Z
Alternative name(s):
Aquaporin X
Gene names
Name:aqpZ
Synonyms:aqpX
Ordered Locus Names:BruAb1_1976
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transport of water across the membrane. Possibly involved in the adaptation to variation in intravacuolar pH or osmolarity By similarity. HAMAP-Rule MF_01146

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01146

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01146.

Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). HAMAP-Rule MF_01146

Sequence similarities

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainRepeat
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionwater channel activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 228228Aquaporin Z HAMAP-Rule MF_01146
PRO_0000063983

Regions

Topological domain1 – 66Cytoplasmic Potential
Transmembrane7 – 2923Helical; Name=1; Potential
Topological domain30 – 334Periplasmic Potential
Transmembrane34 – 5623Helical; Name=2; Potential
Topological domain57 – 8024Cytoplasmic Potential
Transmembrane81 – 10323Helical; Name=3; Potential
Topological domain104 – 12623Periplasmic Potential
Transmembrane127 – 14923Helical; Name=4; Potential
Topological domain150 – 1534Cytoplasmic Potential
Transmembrane154 – 17623Helical; Name=5; Potential
Topological domain177 – 20226Periplasmic Potential
Transmembrane203 – 22523Helical; Name=6; Potential
Topological domain226 – 2283Cytoplasmic Potential
Motif63 – 653NPA 1 HAMAP-Rule MF_01146
Motif184 – 1863NPA 2 HAMAP-Rule MF_01146
Compositional bias92 – 976Poly-Ala HAMAP-Rule MF_01146

Sites

Site201Involved in tetramerization or stability of the tetramer By similarity
Site431Selectivity filter By similarity
Site1721Selectivity filter By similarity
Site1811Selectivity filter By similarity
Site1871Selectivity filter By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C112 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 23C64C39E4DD444A

FASTA22823,145
        10         20         30         40         50         60 
MLNKLSAEFF GTFWLVFGGC GSAILAAAFP ELGIGFLGVA LAFGLTVLTM AYAVGGISGG 

        70         80         90        100        110        120 
HFNPAVSLGL TVAGRLPAKD LIPYWVAQVL GAIAAAAILY VIASGKDGFS AGGLASNGYG 

       130        140        150        160        170        180 
ELSPGGYSMM AGLLIEIILT AFFIIIILGS TSSLAPAGFA PIAIGFGLTL IHLVSIPVTN 

       190        200        210        220 
TSVNPARSTG VALFADRAAL SQLWLFWVAP LVGAVIGAII WKGLLGRD 

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017223 Genomic DNA. Translation: AAX75280.1.
RefSeqYP_222641.1. NC_006932.1.

3D structure databases

ProteinModelPortalP0C112.
SMRP0C112. Positions 1-225.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262698.BruAb1_1976.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX75280; AAX75280; BruAb1_1976.
GeneID3340159.
KEGGbmb:BruAb1_1976.
PATRIC17825793. VBIBruAbo15061_2086.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0580.
HOGENOMHOG000288286.
KOK06188.
OMAMPIIGGI.
OrthoDBEOG6GFGN7.
ProtClustDBPRK05420.

Enzyme and pathway databases

BioCycBABO262698:GJC2-2025-MONOMER.

Family and domain databases

Gene3D1.20.1080.10. 1 hit.
HAMAPMF_01146. Aquaporin_Z.
InterProIPR023271. Aquaporin-like.
IPR023743. Aquaporin_Z.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERPTHR19139. PTHR19139. 1 hit.
PfamPF00230. MIP. 1 hit.
[Graphical view]
PRINTSPR00783. MINTRINSICP.
SUPFAMSSF81338. SSF81338. 1 hit.
TIGRFAMsTIGR00861. MIP. 1 hit.
PROSITEPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAQPZ_BRUAB
AccessionPrimary (citable) accession number: P0C112
Secondary accession number(s): Q57AQ4, Q9LA79
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names