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P0C112

- AQPZ_BRUAB

UniProt

P0C112 - AQPZ_BRUAB

Protein

Aquaporin Z

Gene

aqpZ

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Transport of water across the membrane. Possibly involved in the adaptation to variation in intravacuolar pH or osmolarity By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei20 – 201Involved in tetramerization or stability of the tetramerBy similarity
    Sitei43 – 431Selectivity filterBy similarity
    Sitei172 – 1721Selectivity filterBy similarity
    Sitei181 – 1811Selectivity filterBy similarity
    Sitei187 – 1871Selectivity filterBy similarity

    GO - Molecular functioni

    1. water channel activity Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-2025-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aquaporin Z
    Alternative name(s):
    Aquaporin X
    Gene namesi
    Name:aqpZ
    Synonyms:aqpX
    Ordered Locus Names:BruAb1_1976
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 228228Aquaporin ZPRO_0000063983Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi262698.BruAb1_1976.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C112.
    SMRiP0C112. Positions 1-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66CytoplasmicSequence Analysis
    Topological domaini30 – 334PeriplasmicSequence Analysis
    Topological domaini57 – 8024CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini104 – 12623PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini150 – 1534CytoplasmicSequence Analysis
    Topological domaini177 – 20226PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini226 – 2283CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2923Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei34 – 5623Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei81 – 10323Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei127 – 14923Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei154 – 17623Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22523Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi63 – 653NPA 1
    Motifi184 – 1863NPA 2

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi92 – 976Poly-Ala

    Domaini

    Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0580.
    HOGENOMiHOG000288286.
    KOiK06188.
    OMAiFITEVTM.
    OrthoDBiEOG6GFGN7.

    Family and domain databases

    Gene3Di1.20.1080.10. 1 hit.
    HAMAPiMF_01146. Aquaporin_Z.
    InterProiIPR023271. Aquaporin-like.
    IPR023743. Aquaporin_Z.
    IPR000425. MIP.
    IPR022357. MIP_CS.
    [Graphical view]
    PANTHERiPTHR19139. PTHR19139. 1 hit.
    PfamiPF00230. MIP. 1 hit.
    [Graphical view]
    PRINTSiPR00783. MINTRINSICP.
    SUPFAMiSSF81338. SSF81338. 1 hit.
    TIGRFAMsiTIGR00861. MIP. 1 hit.
    PROSITEiPS00221. MIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C112-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNKLSAEFF GTFWLVFGGC GSAILAAAFP ELGIGFLGVA LAFGLTVLTM    50
    AYAVGGISGG HFNPAVSLGL TVAGRLPAKD LIPYWVAQVL GAIAAAAILY 100
    VIASGKDGFS AGGLASNGYG ELSPGGYSMM AGLLIEIILT AFFIIIILGS 150
    TSSLAPAGFA PIAIGFGLTL IHLVSIPVTN TSVNPARSTG VALFADRAAL 200
    SQLWLFWVAP LVGAVIGAII WKGLLGRD 228
    Length:228
    Mass (Da):23,145
    Last modified:February 7, 2006 - v1
    Checksum:i23C64C39E4DD444A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX75280.1.
    RefSeqiYP_222641.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX75280; AAX75280; BruAb1_1976.
    GeneIDi3340159.
    KEGGibmb:BruAb1_1976.
    PATRICi17825793. VBIBruAbo15061_2086.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX75280.1 .
    RefSeqi YP_222641.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali P0C112.
    SMRi P0C112. Positions 1-225.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_1976.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX75280 ; AAX75280 ; BruAb1_1976 .
    GeneIDi 3340159.
    KEGGi bmb:BruAb1_1976.
    PATRICi 17825793. VBIBruAbo15061_2086.

    Phylogenomic databases

    eggNOGi COG0580.
    HOGENOMi HOG000288286.
    KOi K06188.
    OMAi FITEVTM.
    OrthoDBi EOG6GFGN7.

    Enzyme and pathway databases

    BioCyci BABO262698:GJC2-2025-MONOMER.

    Family and domain databases

    Gene3Di 1.20.1080.10. 1 hit.
    HAMAPi MF_01146. Aquaporin_Z.
    InterProi IPR023271. Aquaporin-like.
    IPR023743. Aquaporin_Z.
    IPR000425. MIP.
    IPR022357. MIP_CS.
    [Graphical view ]
    PANTHERi PTHR19139. PTHR19139. 1 hit.
    Pfami PF00230. MIP. 1 hit.
    [Graphical view ]
    PRINTSi PR00783. MINTRINSICP.
    SUPFAMi SSF81338. SSF81338. 1 hit.
    TIGRFAMsi TIGR00861. MIP. 1 hit.
    PROSITEi PS00221. MIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiAQPZ_BRUAB
    AccessioniPrimary (citable) accession number: P0C112
    Secondary accession number(s): Q57AQ4, Q9LA79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3