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P0C112

- AQPZ_BRUAB

UniProt

P0C112 - AQPZ_BRUAB

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Protein

Aquaporin Z

Gene

aqpZ

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Transport of water across the membrane. Possibly involved in the adaptation to variation in intravacuolar pH or osmolarity (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei20 – 201Involved in tetramerization or stability of the tetramerBy similarity
Sitei43 – 431Selectivity filterBy similarity
Sitei172 – 1721Selectivity filterBy similarity
Sitei181 – 1811Selectivity filterBy similarity
Sitei187 – 1871Selectivity filterBy similarity

GO - Molecular functioni

  1. water channel activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2025-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin Z
Alternative name(s):
Aquaporin X
Gene namesi
Name:aqpZ
Synonyms:aqpX
Ordered Locus Names:BruAb1_1976
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence Analysis
Transmembranei7 – 2923Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini30 – 334PeriplasmicSequence Analysis
Transmembranei34 – 5623Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini57 – 8024CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei81 – 10323Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini104 – 12623PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei127 – 14923Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini150 – 1534CytoplasmicSequence Analysis
Transmembranei154 – 17623Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini177 – 20226PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei203 – 22523Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini226 – 2283CytoplasmicSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Aquaporin ZPRO_0000063983Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi262698.BruAb1_1976.

Structurei

3D structure databases

ProteinModelPortaliP0C112.
SMRiP0C112. Positions 1-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi63 – 653NPA 1
Motifi184 – 1863NPA 2

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi92 – 976Poly-Ala

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0580.
HOGENOMiHOG000288286.
KOiK06188.
OMAiFITEVTM.
OrthoDBiEOG6GFGN7.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
HAMAPiMF_01146. Aquaporin_Z.
InterProiIPR023271. Aquaporin-like.
IPR023743. Aquaporin_Z.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C112-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNKLSAEFF GTFWLVFGGC GSAILAAAFP ELGIGFLGVA LAFGLTVLTM
60 70 80 90 100
AYAVGGISGG HFNPAVSLGL TVAGRLPAKD LIPYWVAQVL GAIAAAAILY
110 120 130 140 150
VIASGKDGFS AGGLASNGYG ELSPGGYSMM AGLLIEIILT AFFIIIILGS
160 170 180 190 200
TSSLAPAGFA PIAIGFGLTL IHLVSIPVTN TSVNPARSTG VALFADRAAL
210 220
SQLWLFWVAP LVGAVIGAII WKGLLGRD
Length:228
Mass (Da):23,145
Last modified:February 7, 2006 - v1
Checksum:i23C64C39E4DD444A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX75280.1.
RefSeqiYP_222641.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX75280; AAX75280; BruAb1_1976.
GeneIDi3340159.
KEGGibmb:BruAb1_1976.
PATRICi17825793. VBIBruAbo15061_2086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX75280.1 .
RefSeqi YP_222641.1. NC_006932.1.

3D structure databases

ProteinModelPortali P0C112.
SMRi P0C112. Positions 1-225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb1_1976.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX75280 ; AAX75280 ; BruAb1_1976 .
GeneIDi 3340159.
KEGGi bmb:BruAb1_1976.
PATRICi 17825793. VBIBruAbo15061_2086.

Phylogenomic databases

eggNOGi COG0580.
HOGENOMi HOG000288286.
KOi K06188.
OMAi FITEVTM.
OrthoDBi EOG6GFGN7.

Enzyme and pathway databases

BioCyci BABO262698:GJC2-2025-MONOMER.

Family and domain databases

Gene3Di 1.20.1080.10. 1 hit.
HAMAPi MF_01146. Aquaporin_Z.
InterProi IPR023271. Aquaporin-like.
IPR023743. Aquaporin_Z.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view ]
PANTHERi PTHR19139. PTHR19139. 1 hit.
Pfami PF00230. MIP. 1 hit.
[Graphical view ]
PRINTSi PR00783. MINTRINSICP.
SUPFAMi SSF81338. SSF81338. 1 hit.
TIGRFAMsi TIGR00861. MIP. 1 hit.
PROSITEi PS00221. MIP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiAQPZ_BRUAB
AccessioniPrimary (citable) accession number: P0C112
Secondary accession number(s): Q57AQ4, Q9LA79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3