P0C112 (AQPZ_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aquaporin Z

Alternative name(s):
Aquaporin X

Gene names

Name:	aqpZ
Synonyms:	aqpX
Ordered Locus Names:	BruAb1_1976

Organism

Brucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]

Taxonomic identifier

262698 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus › Brucella abortus bv. 1

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transport of water across the membrane. Possibly involved in the adaptation to variation in intravacuolar pH or osmolarity By similarity. HAMAP-Rule MF_01146
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_01146
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01146.
Domain	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). HAMAP-Rule MF_01146
Sequence similarities	Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	water channel activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 228	228	Aquaporin Z HAMAP-Rule MF_01146		PRO_0000063983
Regions
	Topological domain	1 – 6	6	Cytoplasmic Potential
	Transmembrane	7 – 29	23	Helical; Name=1; Potential
	Topological domain	30 – 33	4	Periplasmic Potential
	Transmembrane	34 – 56	23	Helical; Name=2; Potential
	Topological domain	57 – 80	24	Cytoplasmic Potential
	Transmembrane	81 – 103	23	Helical; Name=3; Potential
	Topological domain	104 – 126	23	Periplasmic Potential
	Transmembrane	127 – 149	23	Helical; Name=4; Potential
	Topological domain	150 – 153	4	Cytoplasmic Potential
	Transmembrane	154 – 176	23	Helical; Name=5; Potential
	Topological domain	177 – 202	26	Periplasmic Potential
	Transmembrane	203 – 225	23	Helical; Name=6; Potential
	Topological domain	226 – 228	3	Cytoplasmic Potential
	Motif	63 – 65	3	NPA 1 HAMAP-Rule MF_01146
	Motif	184 – 186	3	NPA 2 HAMAP-Rule MF_01146
	Compositional bias	92 – 97	6	Poly-Ala HAMAP-Rule MF_01146
Sites
	Site	20	1	Involved in tetramerization or stability of the tetramer By similarity
	Site	43	1	Selectivity filter By similarity
	Site	172	1	Selectivity filter By similarity
	Site	181	1	Selectivity filter By similarity
	Site	187	1	Selectivity filter By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C112 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 23C64C39E4DD444A	FASTA	228	23,145
	10 20 30 40 50 60 MLNKLSAEFF GTFWLVFGGC GSAILAAAFP ELGIGFLGVA LAFGLTVLTM AYAVGGISGG 70 80 90 100 110 120 HFNPAVSLGL TVAGRLPAKD LIPYWVAQVL GAIAAAAILY VIASGKDGFS AGGLASNGYG 130 140 150 160 170 180 ELSPGGYSMM AGLLIEIILT AFFIIIILGS TSSLAPAGFA PIAIGFGLTL IHLVSIPVTN 190 200 210 220 TSVNPARSTG VALFADRAAL SQLWLFWVAP LVGAVIGAII WKGLLGRD

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017223 Genomic DNA. Translation: AAX75280.1.
RefSeq	YP_222641.1. NC_006932.1.
3D structure databases
ProteinModelPortal	P0C112.
SMR	P0C112. Positions 1-225.
ModBase	Search...
Protein-protein interaction databases
STRING	262698.BruAb1_1976.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAX75280; AAX75280; BruAb1_1976.
GeneID	3340159.
KEGG	bmb:BruAb1_1976.
PATRIC	17825793. VBIBruAbo15061_2086.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0580.
HOGENOM	HOG000288286.
KO	K06188.
OMA	EIVMTLF.
ProtClustDB	PRK05420.
Enzyme and pathway databases
BioCyc	BABO262698:GJC2-2025-MONOMER.
Family and domain databases
Gene3D	1.20.1080.10. 1 hit.
HAMAP	MF_01146. Aquaporin_Z.
InterPro	IPR023271. Aquaporin-like. IPR023743. Aquaporin_Z. IPR000425. MIP. IPR022357. MIP_CS. [Graphical view]
PANTHER	PTHR19139. PTHR19139. 1 hit.
Pfam	PF00230. MIP. 1 hit. [Graphical view]
PRINTS	PR00783. MINTRINSICP.
SUPFAM	SSF81338. MIP. 1 hit.
TIGRFAMs	TIGR00861. MIP. 1 hit.
PROSITE	PS00221. MIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AQPZ_BRUAB

Accession

Primary (citable) accession number: P0C112
Secondary accession number(s): Q57AQ4, Q9LA79

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program