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P0C111

- LPXD_BRUAB

UniProt

P0C111 - LPXD_BRUAB

Protein

UDP-3-O-acylglucosamine N-acyltransferase

Gene

lpxD

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    (3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein].UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei257 – 2571Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. transferase activity, transferring acyl groups other than amino-acyl groups Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-1181-MONOMER.
    UniPathwayiUPA00973.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-3-O-acylglucosamine N-acyltransferaseUniRule annotation (EC:2.3.1.-UniRule annotation)
    Gene namesi
    Name:lpxDUniRule annotation
    Ordered Locus Names:BruAb1_1159
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351UDP-3-O-acylglucosamine N-acyltransferasePRO_0000059652Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi262698.BruAb1_1159.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transferase hexapeptide repeat family. LpxD subfamily.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1044.
    HOGENOMiHOG000294340.
    KOiK02536.
    OMAiSHIHIGH.
    OrthoDBiEOG6JB11D.

    Family and domain databases

    HAMAPiMF_00523. LpxD.
    InterProiIPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR011004. Trimer_LpxA-like.
    IPR007691. UDP-3-O_GlcNAc_AcTrfase.
    IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
    [Graphical view]
    PfamiPF00132. Hexapep. 3 hits.
    PF04613. LpxD. 1 hit.
    [Graphical view]
    SUPFAMiSSF51161. SSF51161. 1 hit.
    TIGRFAMsiTIGR01853. lipid_A_lpxD. 1 hit.
    PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C111-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADPIFFKPS RELTIGDVAD FTGASLRDPK LAPRSVERLA SLKDAGEGAL    50
    VFVEGKKNVS SLVGLKAAGV LCTESLADSV PSGIAVLVSR HPHRDFSAVG 100
    RMLFPASVRP ESWLGETGIS PAAFIHPTAQ IEDGATVEAG AVIGSGVTIG 150
    AGTLIAATAV IGQNCQIGRN SYIAPGVSVQ CAFIGNNVSL HPGVRIGQDG 200
    FGYVPGAAGL DKVPQLGRVI IQDNVEIGAN TTVDRGSLDD TVIGEGTKID 250
    NLVQIAHNVR IGRFCLVAAH CGISGSCVIG DQTMLGGRVG LADHLIIGSR 300
    VQVAAASGVM NDIPDGERWG GIPARPIKQW FRDIANIRSI GQSRKDASSD 350
    E 351
    Length:351
    Mass (Da):36,357
    Last modified:February 7, 2006 - v1
    Checksum:iECC1ED7ED029D01A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX74498.1.
    RefSeqiYP_221859.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX74498; AAX74498; BruAb1_1159.
    GeneIDi3339833.
    KEGGibmb:BruAb1_1159.
    PATRICi17824006. VBIBruAbo15061_1225.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX74498.1 .
    RefSeqi YP_221859.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali P0C111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_1159.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX74498 ; AAX74498 ; BruAb1_1159 .
    GeneIDi 3339833.
    KEGGi bmb:BruAb1_1159.
    PATRICi 17824006. VBIBruAbo15061_1225.

    Phylogenomic databases

    eggNOGi COG1044.
    HOGENOMi HOG000294340.
    KOi K02536.
    OMAi SHIHIGH.
    OrthoDBi EOG6JB11D.

    Enzyme and pathway databases

    UniPathwayi UPA00973 .
    BioCyci BABO262698:GJC2-1181-MONOMER.

    Family and domain databases

    HAMAPi MF_00523. LpxD.
    InterProi IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR011004. Trimer_LpxA-like.
    IPR007691. UDP-3-O_GlcNAc_AcTrfase.
    IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
    [Graphical view ]
    Pfami PF00132. Hexapep. 3 hits.
    PF04613. LpxD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51161. SSF51161. 1 hit.
    TIGRFAMsi TIGR01853. lipid_A_lpxD. 1 hit.
    PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiLPXD_BRUAB
    AccessioniPrimary (citable) accession number: P0C111
    Secondary accession number(s): P0A3P6, Q44630, Q57CY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3