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Protein

UDP-3-O-acylglucosamine N-acyltransferase

Gene

lpxD

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein].UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei257 – 2571Proton acceptorUniRule annotation

GO - Molecular functioni

  1. transferase activity, transferring acyl groups other than amino-acyl groups Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBABO262698:GJC2-1181-MONOMER.
UniPathwayiUPA00973.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-3-O-acylglucosamine N-acyltransferaseUniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
Name:lpxDUniRule annotation
Ordered Locus Names:BruAb1_1159
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351UDP-3-O-acylglucosamine N-acyltransferasePRO_0000059652Add
BLAST

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi262698.BruAb1_1159.

Structurei

3D structure databases

ProteinModelPortaliP0C111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. LpxD subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1044.
HOGENOMiHOG000294340.
KOiK02536.
OMAiYKAFALI.
OrthoDBiEOG6JB11D.

Family and domain databases

HAMAPiMF_00523. LpxD.
InterProiIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR011004. Trimer_LpxA-like.
IPR007691. UDP-3-O_GlcNAc_AcTrfase.
IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
[Graphical view]
PfamiPF00132. Hexapep. 3 hits.
PF04613. LpxD. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01853. lipid_A_lpxD. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPIFFKPS RELTIGDVAD FTGASLRDPK LAPRSVERLA SLKDAGEGAL
60 70 80 90 100
VFVEGKKNVS SLVGLKAAGV LCTESLADSV PSGIAVLVSR HPHRDFSAVG
110 120 130 140 150
RMLFPASVRP ESWLGETGIS PAAFIHPTAQ IEDGATVEAG AVIGSGVTIG
160 170 180 190 200
AGTLIAATAV IGQNCQIGRN SYIAPGVSVQ CAFIGNNVSL HPGVRIGQDG
210 220 230 240 250
FGYVPGAAGL DKVPQLGRVI IQDNVEIGAN TTVDRGSLDD TVIGEGTKID
260 270 280 290 300
NLVQIAHNVR IGRFCLVAAH CGISGSCVIG DQTMLGGRVG LADHLIIGSR
310 320 330 340 350
VQVAAASGVM NDIPDGERWG GIPARPIKQW FRDIANIRSI GQSRKDASSD

E
Length:351
Mass (Da):36,357
Last modified:February 7, 2006 - v1
Checksum:iECC1ED7ED029D01A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX74498.1.
RefSeqiYP_221859.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX74498; AAX74498; BruAb1_1159.
GeneIDi3339833.
KEGGibmb:BruAb1_1159.
PATRICi17824006. VBIBruAbo15061_1225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX74498.1.
RefSeqiYP_221859.1. NC_006932.1.

3D structure databases

ProteinModelPortaliP0C111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262698.BruAb1_1159.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX74498; AAX74498; BruAb1_1159.
GeneIDi3339833.
KEGGibmb:BruAb1_1159.
PATRICi17824006. VBIBruAbo15061_1225.

Phylogenomic databases

eggNOGiCOG1044.
HOGENOMiHOG000294340.
KOiK02536.
OMAiYKAFALI.
OrthoDBiEOG6JB11D.

Enzyme and pathway databases

UniPathwayiUPA00973.
BioCyciBABO262698:GJC2-1181-MONOMER.

Family and domain databases

HAMAPiMF_00523. LpxD.
InterProiIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR011004. Trimer_LpxA-like.
IPR007691. UDP-3-O_GlcNAc_AcTrfase.
IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
[Graphical view]
PfamiPF00132. Hexapep. 3 hits.
PF04613. LpxD. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01853. lipid_A_lpxD. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiLPXD_BRUAB
AccessioniPrimary (citable) accession number: P0C111
Secondary accession number(s): P0A3P6, Q44630, Q57CY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: January 7, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.